| Full name: amyloid P component, serum | Alias Symbol: SAP|PTX2|MGC88159 | ||
| Type: protein-coding gene | Cytoband: 1q23.2 | ||
| Entrez ID: 325 | HGNC ID: HGNC:584 | Ensembl Gene: ENSG00000132703 | OMIM ID: 104770 |
| Drug and gene relationship at DGIdb | |||
Expression of APCS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APCS | 325 | 206350_at | 0.0427 | 0.8392 | |
| GSE20347 | APCS | 325 | 206350_at | -0.0202 | 0.8231 | |
| GSE23400 | APCS | 325 | 206350_at | -0.1314 | 0.0008 | |
| GSE26886 | APCS | 325 | 206350_at | -0.2168 | 0.1933 | |
| GSE29001 | APCS | 325 | 206350_at | -0.1078 | 0.4755 | |
| GSE38129 | APCS | 325 | 206350_at | -0.1022 | 0.0708 | |
| GSE45670 | APCS | 325 | 206350_at | 0.0062 | 0.9561 | |
| GSE53622 | APCS | 325 | 10045 | 1.1858 | 0.0000 | |
| GSE53624 | APCS | 325 | 10045 | 0.8255 | 0.0000 | |
| GSE63941 | APCS | 325 | 206350_at | -0.0044 | 0.9806 | |
| GSE77861 | APCS | 325 | 206350_at | 0.0295 | 0.8446 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by APCS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APCS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APCS | 325 | 10 | 0 | 20 | |
| GSE20123 | APCS | 325 | 10 | 0 | 20 | |
| GSE43470 | APCS | 325 | 7 | 2 | 34 | |
| GSE46452 | APCS | 325 | 2 | 1 | 56 | |
| GSE47630 | APCS | 325 | 14 | 0 | 26 | |
| GSE54993 | APCS | 325 | 0 | 5 | 65 | |
| GSE54994 | APCS | 325 | 16 | 0 | 37 | |
| GSE60625 | APCS | 325 | 0 | 0 | 11 | |
| GSE74703 | APCS | 325 | 7 | 2 | 27 | |
| GSE74704 | APCS | 325 | 4 | 0 | 16 | |
| TCGA | APCS | 325 | 43 | 3 | 50 |
Total number of gains: 113; Total number of losses: 13; Total Number of normals: 362.
Somatic mutations of APCS:
Generating mutation plots.
Highly correlated genes for APCS:
Showing top 20/583 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APCS | SLC6A5 | 0.717249 | 4 | 0 | 4 |
| APCS | ZNF598 | 0.710532 | 4 | 0 | 4 |
| APCS | SLC22A11 | 0.704902 | 3 | 0 | 3 |
| APCS | MEP1B | 0.699806 | 4 | 0 | 4 |
| APCS | CIITA | 0.686382 | 3 | 0 | 3 |
| APCS | ZNF460 | 0.680441 | 3 | 0 | 3 |
| APCS | LINC01107 | 0.679338 | 4 | 0 | 4 |
| APCS | GRM2 | 0.677931 | 3 | 0 | 3 |
| APCS | ORM1 | 0.676735 | 3 | 0 | 3 |
| APCS | LINC00474 | 0.674626 | 3 | 0 | 3 |
| APCS | RASSF7 | 0.674215 | 3 | 0 | 3 |
| APCS | GK2 | 0.669987 | 3 | 0 | 3 |
| APCS | NEUROD2 | 0.660607 | 3 | 0 | 3 |
| APCS | FOXD2-AS1 | 0.659903 | 3 | 0 | 3 |
| APCS | HOXB1 | 0.656028 | 4 | 0 | 3 |
| APCS | CHRNA2 | 0.654287 | 5 | 0 | 5 |
| APCS | SHOX | 0.653519 | 5 | 0 | 4 |
| APCS | TSPO2 | 0.652835 | 8 | 0 | 7 |
| APCS | FRAS1 | 0.649746 | 3 | 0 | 3 |
| APCS | RNF17 | 0.648875 | 4 | 0 | 3 |
For details and further investigation, click here
