| Full name: lysophospholipase 2 | Alias Symbol: APT-2 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 11313 | HGNC ID: HGNC:6738 | Ensembl Gene: ENSG00000011009 | OMIM ID: 616143 |
| Drug and gene relationship at DGIdb | |||
Expression of LYPLA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LYPLA2 | 11313 | 202292_x_at | 0.1824 | 0.6381 | |
| GSE20347 | LYPLA2 | 11313 | 202292_x_at | -0.1816 | 0.0468 | |
| GSE23400 | LYPLA2 | 11313 | 202292_x_at | -0.0377 | 0.4176 | |
| GSE26886 | LYPLA2 | 11313 | 202292_x_at | -0.2831 | 0.1316 | |
| GSE29001 | LYPLA2 | 11313 | 202292_x_at | -0.3890 | 0.0322 | |
| GSE38129 | LYPLA2 | 11313 | 202292_x_at | -0.0007 | 0.9956 | |
| GSE45670 | LYPLA2 | 11313 | 202292_x_at | 0.1477 | 0.1637 | |
| GSE53622 | LYPLA2 | 11313 | 53004 | -0.1423 | 0.1111 | |
| GSE53624 | LYPLA2 | 11313 | 53004 | -0.1680 | 0.0020 | |
| GSE63941 | LYPLA2 | 11313 | 202292_x_at | 0.6101 | 0.0520 | |
| GSE77861 | LYPLA2 | 11313 | 202292_x_at | -0.2582 | 0.1094 | |
| GSE97050 | LYPLA2 | 11313 | A_33_P3318671 | 0.3294 | 0.3825 | |
| SRP007169 | LYPLA2 | 11313 | RNAseq | -1.3771 | 0.0002 | |
| SRP008496 | LYPLA2 | 11313 | RNAseq | -1.2706 | 0.0000 | |
| SRP064894 | LYPLA2 | 11313 | RNAseq | 0.3167 | 0.2731 | |
| SRP133303 | LYPLA2 | 11313 | RNAseq | -0.2017 | 0.3320 | |
| SRP159526 | LYPLA2 | 11313 | RNAseq | -0.2317 | 0.4185 | |
| SRP193095 | LYPLA2 | 11313 | RNAseq | -0.4161 | 0.0001 | |
| SRP219564 | LYPLA2 | 11313 | RNAseq | -0.2284 | 0.5568 | |
| TCGA | LYPLA2 | 11313 | RNAseq | 0.0360 | 0.5204 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LYPLA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LYPLA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LYPLA2 | 11313 | 0 | 5 | 25 | |
| GSE20123 | LYPLA2 | 11313 | 0 | 4 | 26 | |
| GSE43470 | LYPLA2 | 11313 | 2 | 6 | 35 | |
| GSE46452 | LYPLA2 | 11313 | 5 | 1 | 53 | |
| GSE47630 | LYPLA2 | 11313 | 8 | 3 | 29 | |
| GSE54993 | LYPLA2 | 11313 | 2 | 1 | 67 | |
| GSE54994 | LYPLA2 | 11313 | 11 | 4 | 38 | |
| GSE60625 | LYPLA2 | 11313 | 0 | 0 | 11 | |
| GSE74703 | LYPLA2 | 11313 | 1 | 4 | 31 | |
| GSE74704 | LYPLA2 | 11313 | 0 | 0 | 20 | |
| TCGA | LYPLA2 | 11313 | 9 | 24 | 63 |
Total number of gains: 38; Total number of losses: 52; Total Number of normals: 398.
Somatic mutations of LYPLA2:
Generating mutation plots.
Highly correlated genes for LYPLA2:
Showing top 20/559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LYPLA2 | GPSM3 | 0.775961 | 3 | 0 | 3 |
| LYPLA2 | PGC | 0.7466 | 3 | 0 | 3 |
| LYPLA2 | AGAP3 | 0.728019 | 3 | 0 | 3 |
| LYPLA2 | AHSP | 0.703728 | 4 | 0 | 3 |
| LYPLA2 | NOBOX | 0.695748 | 3 | 0 | 3 |
| LYPLA2 | MEF2D | 0.693812 | 3 | 0 | 3 |
| LYPLA2 | KDF1 | 0.690738 | 5 | 0 | 5 |
| LYPLA2 | ADAM11 | 0.680571 | 4 | 0 | 4 |
| LYPLA2 | SGK2 | 0.671138 | 4 | 0 | 4 |
| LYPLA2 | LALBA | 0.670982 | 3 | 0 | 3 |
| LYPLA2 | NEUROD4 | 0.668355 | 3 | 0 | 3 |
| LYPLA2 | CACNB3 | 0.668013 | 4 | 0 | 4 |
| LYPLA2 | GRM2 | 0.665633 | 3 | 0 | 3 |
| LYPLA2 | GDF3 | 0.662988 | 4 | 0 | 4 |
| LYPLA2 | DXO | 0.65499 | 3 | 0 | 3 |
| LYPLA2 | PNPLA2 | 0.652352 | 5 | 0 | 5 |
| LYPLA2 | FAM83F | 0.651185 | 4 | 0 | 4 |
| LYPLA2 | SH3BGRL3 | 0.650333 | 10 | 0 | 10 |
| LYPLA2 | SLC39A11 | 0.650202 | 4 | 0 | 4 |
| LYPLA2 | KLHDC3 | 0.649564 | 3 | 0 | 3 |
For details and further investigation, click here
