| Full name: general transcription factor IIIA | Alias Symbol: TFIIIA|AP2 | ||
| Type: protein-coding gene | Cytoband: 13q12.2 | ||
| Entrez ID: 2971 | HGNC ID: HGNC:4662 | Ensembl Gene: ENSG00000122034 | OMIM ID: 600860 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GTF3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF3A | 2971 | 201338_x_at | 0.0936 | 0.7179 | |
| GSE20347 | GTF3A | 2971 | 201338_x_at | -0.0199 | 0.9122 | |
| GSE23400 | GTF3A | 2971 | 201338_x_at | 0.1659 | 0.0396 | |
| GSE26886 | GTF3A | 2971 | 215091_s_at | 0.3208 | 0.2500 | |
| GSE29001 | GTF3A | 2971 | 201338_x_at | -0.2999 | 0.4045 | |
| GSE38129 | GTF3A | 2971 | 201338_x_at | 0.0505 | 0.7065 | |
| GSE45670 | GTF3A | 2971 | 201338_x_at | -0.0373 | 0.8567 | |
| GSE53622 | GTF3A | 2971 | 11286 | -0.1302 | 0.0481 | |
| GSE53624 | GTF3A | 2971 | 11286 | 0.1616 | 0.0062 | |
| GSE63941 | GTF3A | 2971 | 201338_x_at | 0.0282 | 0.9516 | |
| GSE77861 | GTF3A | 2971 | 201338_x_at | -0.0336 | 0.9361 | |
| GSE97050 | GTF3A | 2971 | A_23_P25525 | 0.0224 | 0.9329 | |
| SRP007169 | GTF3A | 2971 | RNAseq | -0.9729 | 0.0046 | |
| SRP008496 | GTF3A | 2971 | RNAseq | -0.5771 | 0.0260 | |
| SRP064894 | GTF3A | 2971 | RNAseq | 0.3638 | 0.1870 | |
| SRP133303 | GTF3A | 2971 | RNAseq | 0.2962 | 0.1820 | |
| SRP159526 | GTF3A | 2971 | RNAseq | -0.2429 | 0.2230 | |
| SRP193095 | GTF3A | 2971 | RNAseq | -0.6160 | 0.0001 | |
| SRP219564 | GTF3A | 2971 | RNAseq | -0.2333 | 0.5334 | |
| TCGA | GTF3A | 2971 | RNAseq | -0.0759 | 0.2034 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GTF3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF3A | 2971 | 1 | 13 | 16 | |
| GSE20123 | GTF3A | 2971 | 1 | 12 | 17 | |
| GSE43470 | GTF3A | 2971 | 2 | 12 | 29 | |
| GSE46452 | GTF3A | 2971 | 0 | 33 | 26 | |
| GSE47630 | GTF3A | 2971 | 3 | 26 | 11 | |
| GSE54993 | GTF3A | 2971 | 11 | 2 | 57 | |
| GSE54994 | GTF3A | 2971 | 1 | 13 | 39 | |
| GSE60625 | GTF3A | 2971 | 0 | 3 | 8 | |
| GSE74703 | GTF3A | 2971 | 2 | 9 | 25 | |
| GSE74704 | GTF3A | 2971 | 0 | 10 | 10 | |
| TCGA | GTF3A | 2971 | 6 | 41 | 49 |
Total number of gains: 27; Total number of losses: 174; Total Number of normals: 287.
Somatic mutations of GTF3A:
Generating mutation plots.
Highly correlated genes for GTF3A:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF3A | PIGP | 0.79818 | 3 | 0 | 3 |
| GTF3A | GOLGA5 | 0.764081 | 3 | 0 | 3 |
| GTF3A | BMPR2 | 0.73579 | 3 | 0 | 3 |
| GTF3A | TSNAX | 0.719572 | 3 | 0 | 3 |
| GTF3A | APH1A | 0.718758 | 3 | 0 | 3 |
| GTF3A | ZNF765 | 0.718201 | 3 | 0 | 3 |
| GTF3A | RNF115 | 0.715322 | 3 | 0 | 3 |
| GTF3A | POMGNT1 | 0.712543 | 3 | 0 | 3 |
| GTF3A | ZNF567 | 0.709628 | 3 | 0 | 3 |
| GTF3A | SGMS1 | 0.707353 | 3 | 0 | 3 |
| GTF3A | ZNF35 | 0.706157 | 3 | 0 | 3 |
| GTF3A | VTI1B | 0.70436 | 3 | 0 | 3 |
| GTF3A | MLEC | 0.699792 | 3 | 0 | 3 |
| GTF3A | GATAD2B | 0.690191 | 3 | 0 | 3 |
| GTF3A | RHEB | 0.688033 | 3 | 0 | 3 |
| GTF3A | UCHL5 | 0.686932 | 3 | 0 | 3 |
| GTF3A | TGFBRAP1 | 0.686355 | 4 | 0 | 3 |
| GTF3A | C12orf45 | 0.685785 | 3 | 0 | 3 |
| GTF3A | PRR12 | 0.683671 | 3 | 0 | 3 |
| GTF3A | ATP6V1G1 | 0.683623 | 3 | 0 | 3 |
For details and further investigation, click here
