| Full name: ubiquitin C-terminal hydrolase L5 | Alias Symbol: UCH37|CGI-70|INO80R | ||
| Type: protein-coding gene | Cytoband: 1q31.2 | ||
| Entrez ID: 51377 | HGNC ID: HGNC:19678 | Ensembl Gene: ENSG00000116750 | OMIM ID: 610667 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UCHL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCHL5 | 51377 | 219960_s_at | 0.1844 | 0.7444 | |
| GSE20347 | UCHL5 | 51377 | 219960_s_at | -0.1731 | 0.4849 | |
| GSE23400 | UCHL5 | 51377 | 219960_s_at | 0.0261 | 0.7494 | |
| GSE26886 | UCHL5 | 51377 | 219960_s_at | -0.6936 | 0.0098 | |
| GSE29001 | UCHL5 | 51377 | 219960_s_at | -0.3035 | 0.6062 | |
| GSE38129 | UCHL5 | 51377 | 219960_s_at | 0.0768 | 0.7247 | |
| GSE45670 | UCHL5 | 51377 | 219960_s_at | -0.2265 | 0.1513 | |
| GSE53622 | UCHL5 | 51377 | 15150 | -0.1017 | 0.0929 | |
| GSE53624 | UCHL5 | 51377 | 125987 | -0.0764 | 0.1950 | |
| GSE63941 | UCHL5 | 51377 | 219960_s_at | 1.2120 | 0.0035 | |
| GSE77861 | UCHL5 | 51377 | 219960_s_at | -0.4500 | 0.1203 | |
| GSE97050 | UCHL5 | 51377 | A_24_P188325 | -0.0027 | 0.9962 | |
| SRP007169 | UCHL5 | 51377 | RNAseq | -1.1288 | 0.0047 | |
| SRP008496 | UCHL5 | 51377 | RNAseq | -0.9390 | 0.0000 | |
| SRP064894 | UCHL5 | 51377 | RNAseq | -0.4150 | 0.0753 | |
| SRP133303 | UCHL5 | 51377 | RNAseq | 0.1696 | 0.1506 | |
| SRP159526 | UCHL5 | 51377 | RNAseq | 0.2888 | 0.3636 | |
| SRP193095 | UCHL5 | 51377 | RNAseq | -0.2067 | 0.0140 | |
| SRP219564 | UCHL5 | 51377 | RNAseq | -0.0824 | 0.8451 | |
| TCGA | UCHL5 | 51377 | RNAseq | 0.1348 | 0.0126 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by UCHL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCHL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCHL5 | 51377 | 9 | 1 | 20 | |
| GSE20123 | UCHL5 | 51377 | 9 | 1 | 20 | |
| GSE43470 | UCHL5 | 51377 | 5 | 1 | 37 | |
| GSE46452 | UCHL5 | 51377 | 3 | 1 | 55 | |
| GSE47630 | UCHL5 | 51377 | 14 | 0 | 26 | |
| GSE54993 | UCHL5 | 51377 | 0 | 6 | 64 | |
| GSE54994 | UCHL5 | 51377 | 15 | 0 | 38 | |
| GSE60625 | UCHL5 | 51377 | 0 | 0 | 11 | |
| GSE74703 | UCHL5 | 51377 | 5 | 1 | 30 | |
| GSE74704 | UCHL5 | 51377 | 3 | 1 | 16 | |
| TCGA | UCHL5 | 51377 | 41 | 7 | 48 |
Total number of gains: 104; Total number of losses: 19; Total Number of normals: 365.
Somatic mutations of UCHL5:
Generating mutation plots.
Highly correlated genes for UCHL5:
Showing top 20/652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCHL5 | ELOVL7 | 0.781066 | 3 | 0 | 3 |
| UCHL5 | CTCF | 0.775255 | 3 | 0 | 3 |
| UCHL5 | EZR | 0.762649 | 3 | 0 | 3 |
| UCHL5 | ZNF823 | 0.759322 | 3 | 0 | 3 |
| UCHL5 | WWP1 | 0.759054 | 3 | 0 | 3 |
| UCHL5 | DICER1 | 0.741364 | 3 | 0 | 3 |
| UCHL5 | SCAMP1 | 0.726557 | 3 | 0 | 3 |
| UCHL5 | PRELID1 | 0.721608 | 3 | 0 | 3 |
| UCHL5 | ABLIM2 | 0.720998 | 3 | 0 | 3 |
| UCHL5 | CHCHD1 | 0.715062 | 3 | 0 | 3 |
| UCHL5 | TRIM50 | 0.714517 | 3 | 0 | 3 |
| UCHL5 | ZMYM2 | 0.713225 | 4 | 0 | 4 |
| UCHL5 | TTC39B | 0.706973 | 4 | 0 | 3 |
| UCHL5 | WDR20 | 0.705006 | 3 | 0 | 3 |
| UCHL5 | UBE2J1 | 0.704658 | 4 | 0 | 4 |
| UCHL5 | COPS4 | 0.700455 | 4 | 0 | 3 |
| UCHL5 | PMM2 | 0.698569 | 3 | 0 | 3 |
| UCHL5 | ATP6V1G1 | 0.698556 | 4 | 0 | 4 |
| UCHL5 | ZNF165 | 0.696828 | 5 | 0 | 5 |
| UCHL5 | RSL24D1 | 0.696731 | 4 | 0 | 3 |
For details and further investigation, click here
