RHEB

 

Full name: Ras homolog, mTORC1 binding Alias Symbol: 
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 6009 HGNC ID: HGNC:10011 Ensembl Gene: ENSG00000106615 OMIM ID: 601293
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 300/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RHEB involved pathways:

KEGG pathway Description View
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of RHEB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RHEB 6009 201453_x_at -0.0178 0.9799
GSE20347 RHEB 6009 201453_x_at 0.6753 0.0000
GSE23400 RHEB 6009 201453_x_at 0.5081 0.0000
GSE26886 RHEB 6009 201453_x_at 0.1481 0.4087
GSE29001 RHEB 6009 201453_x_at 0.5700 0.0083
GSE38129 RHEB 6009 201453_x_at 0.5832 0.0000
GSE45670 RHEB 6009 201453_x_at -0.0769 0.7082
GSE53622 RHEB 6009 66185 0.5084 0.0000
GSE53624 RHEB 6009 66185 0.5064 0.0000
GSE63941 RHEB 6009 201453_x_at -0.2649 0.2648
GSE77861 RHEB 6009 201453_x_at 0.4562 0.0157
GSE97050 RHEB 6009 A_32_P124746 -0.0599 0.8520
SRP007169 RHEB 6009 RNAseq 0.4824 0.0985
SRP008496 RHEB 6009 RNAseq 0.6067 0.0000
SRP064894 RHEB 6009 RNAseq 0.3419 0.0207
SRP133303 RHEB 6009 RNAseq 0.7095 0.0000
SRP159526 RHEB 6009 RNAseq 0.4601 0.0326
SRP193095 RHEB 6009 RNAseq 0.3960 0.0015
SRP219564 RHEB 6009 RNAseq -0.0806 0.8143
TCGA RHEB 6009 RNAseq 0.1676 0.0034

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RHEB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RHEB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RHEB 6009 2 4 24
GSE20123 RHEB 6009 2 4 24
GSE43470 RHEB 6009 2 5 36
GSE46452 RHEB 6009 7 2 50
GSE47630 RHEB 6009 5 9 26
GSE54993 RHEB 6009 3 3 64
GSE54994 RHEB 6009 5 8 40
GSE60625 RHEB 6009 0 0 11
GSE74703 RHEB 6009 2 4 30
GSE74704 RHEB 6009 1 4 15
TCGA RHEB 6009 27 25 44

Total number of gains: 56; Total number of losses: 68; Total Number of normals: 364.  

 

Somatic mutations of RHEB:

 

Generating mutation plots.

 

Highly correlated genes for RHEB:

 

Showing top 20/1253 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RHEBNDUFA120.77947303
RHEBRAB340.738319303
RHEBGOLPH30.732482303
RHEBKCNMA10.727047303
RHEBNF10.726241303
RHEBMEX3B0.724925303
RHEBCUL10.72179213013
RHEBFAM20C0.717864303
RHEBZNF100.71544403
RHEBC20orf1940.713062303
RHEBPRKAG20.707772606
RHEBDESI20.706273909
RHEBCHCHD30.7052613013
RHEBTMEM1380.701237505
RHEBSLC38A60.700326606
RHEBNUDT160.69445303
RHEBWDR750.693173303
RHEBCBLL10.69129705
RHEBLRRC340.690618303
RHEBTRIM370.68934110010

For details and further investigation, click here