| Full name: bone morphogenetic protein receptor type 2 | Alias Symbol: BRK-3|T-ALK|BMPR3|BMPR-II | ||
| Type: protein-coding gene | Cytoband: 2q33.1-q33.2 | ||
| Entrez ID: 659 | HGNC ID: HGNC:1078 | Ensembl Gene: ENSG00000204217 | OMIM ID: 600799 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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BMPR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04390 | Hippo signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of BMPR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMPR2 | 659 | 225144_at | -0.2458 | 0.5086 | |
| GSE20347 | BMPR2 | 659 | 209920_at | 0.0766 | 0.4812 | |
| GSE23400 | BMPR2 | 659 | 210214_s_at | 0.1452 | 0.0005 | |
| GSE26886 | BMPR2 | 659 | 225144_at | 0.3705 | 0.1178 | |
| GSE29001 | BMPR2 | 659 | 209920_at | 0.1234 | 0.8232 | |
| GSE38129 | BMPR2 | 659 | 209920_at | 0.1444 | 0.5283 | |
| GSE45670 | BMPR2 | 659 | 225144_at | -0.2941 | 0.1241 | |
| GSE63941 | BMPR2 | 659 | 225144_at | -3.0698 | 0.0001 | |
| GSE77861 | BMPR2 | 659 | 225144_at | 0.2824 | 0.4520 | |
| GSE97050 | BMPR2 | 659 | A_24_P753161 | 0.1264 | 0.5869 | |
| SRP007169 | BMPR2 | 659 | RNAseq | 0.5451 | 0.1323 | |
| SRP008496 | BMPR2 | 659 | RNAseq | 0.8665 | 0.0004 | |
| SRP064894 | BMPR2 | 659 | RNAseq | 0.1930 | 0.3282 | |
| SRP133303 | BMPR2 | 659 | RNAseq | 0.3386 | 0.0157 | |
| SRP159526 | BMPR2 | 659 | RNAseq | -0.1144 | 0.5350 | |
| SRP193095 | BMPR2 | 659 | RNAseq | 0.0541 | 0.5809 | |
| SRP219564 | BMPR2 | 659 | RNAseq | -0.2255 | 0.6447 | |
| TCGA | BMPR2 | 659 | RNAseq | -0.0476 | 0.3734 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by BMPR2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BMPR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMPR2 | 659 | 7 | 4 | 19 | |
| GSE20123 | BMPR2 | 659 | 7 | 4 | 19 | |
| GSE43470 | BMPR2 | 659 | 1 | 3 | 39 | |
| GSE46452 | BMPR2 | 659 | 1 | 4 | 54 | |
| GSE47630 | BMPR2 | 659 | 4 | 5 | 31 | |
| GSE54993 | BMPR2 | 659 | 0 | 3 | 67 | |
| GSE54994 | BMPR2 | 659 | 10 | 8 | 35 | |
| GSE60625 | BMPR2 | 659 | 0 | 3 | 8 | |
| GSE74703 | BMPR2 | 659 | 1 | 2 | 33 | |
| GSE74704 | BMPR2 | 659 | 3 | 2 | 15 | |
| TCGA | BMPR2 | 659 | 21 | 11 | 64 |
Total number of gains: 55; Total number of losses: 49; Total Number of normals: 384.
Somatic mutations of BMPR2:
Generating mutation plots.
Highly correlated genes for BMPR2:
Showing top 20/806 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMPR2 | LRRK2 | 0.838429 | 3 | 0 | 3 |
| BMPR2 | YPEL2 | 0.794109 | 3 | 0 | 3 |
| BMPR2 | ELMO1 | 0.783261 | 3 | 0 | 3 |
| BMPR2 | ZNF225 | 0.778636 | 4 | 0 | 4 |
| BMPR2 | TNFRSF19 | 0.762522 | 3 | 0 | 3 |
| BMPR2 | GAS7 | 0.755299 | 4 | 0 | 4 |
| BMPR2 | CASC4 | 0.754924 | 4 | 0 | 4 |
| BMPR2 | MGAT5 | 0.748418 | 4 | 0 | 3 |
| BMPR2 | RGMB | 0.746756 | 3 | 0 | 3 |
| BMPR2 | BRK1 | 0.74494 | 3 | 0 | 3 |
| BMPR2 | TTC8 | 0.743202 | 3 | 0 | 3 |
| BMPR2 | PAK1 | 0.739586 | 3 | 0 | 3 |
| BMPR2 | RGS18 | 0.738098 | 3 | 0 | 3 |
| BMPR2 | GTF3A | 0.73579 | 3 | 0 | 3 |
| BMPR2 | FMR1 | 0.733189 | 5 | 0 | 5 |
| BMPR2 | MGA | 0.73168 | 3 | 0 | 3 |
| BMPR2 | GPC6 | 0.723553 | 4 | 0 | 4 |
| BMPR2 | PDGFRB | 0.722476 | 4 | 0 | 4 |
| BMPR2 | APPL2 | 0.722422 | 3 | 0 | 3 |
| BMPR2 | ZNF25 | 0.720112 | 6 | 0 | 6 |
For details and further investigation, click here
