| Full name: sphingomyelin synthase 1 | Alias Symbol: MOB|MGC17342|SMS1 | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 259230 | HGNC ID: HGNC:29799 | Ensembl Gene: ENSG00000198964 | OMIM ID: 611573 |
| Drug and gene relationship at DGIdb | |||
Expression of SGMS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGMS1 | 259230 | 212989_at | -0.1812 | 0.8337 | |
| GSE20347 | SGMS1 | 259230 | 212989_at | -0.0642 | 0.8343 | |
| GSE23400 | SGMS1 | 259230 | 212989_at | 0.1404 | 0.1073 | |
| GSE26886 | SGMS1 | 259230 | 212989_at | 0.5291 | 0.0912 | |
| GSE29001 | SGMS1 | 259230 | 212989_at | 0.1180 | 0.8749 | |
| GSE38129 | SGMS1 | 259230 | 212989_at | -0.0656 | 0.7452 | |
| GSE45670 | SGMS1 | 259230 | 212989_at | 0.0439 | 0.8723 | |
| GSE53622 | SGMS1 | 259230 | 22257 | -0.3452 | 0.0038 | |
| GSE53624 | SGMS1 | 259230 | 22257 | -0.2137 | 0.0110 | |
| GSE63941 | SGMS1 | 259230 | 212989_at | -1.6737 | 0.0076 | |
| GSE77861 | SGMS1 | 259230 | 212989_at | -0.1322 | 0.7832 | |
| GSE97050 | SGMS1 | 259230 | A_32_P163125 | 0.0423 | 0.8869 | |
| SRP007169 | SGMS1 | 259230 | RNAseq | 0.1778 | 0.6540 | |
| SRP008496 | SGMS1 | 259230 | RNAseq | -0.1314 | 0.6038 | |
| SRP064894 | SGMS1 | 259230 | RNAseq | -0.0295 | 0.8885 | |
| SRP133303 | SGMS1 | 259230 | RNAseq | 0.2513 | 0.0750 | |
| SRP159526 | SGMS1 | 259230 | RNAseq | -0.3097 | 0.5710 | |
| SRP193095 | SGMS1 | 259230 | RNAseq | 0.0904 | 0.3760 | |
| SRP219564 | SGMS1 | 259230 | RNAseq | -0.2303 | 0.5708 | |
| TCGA | SGMS1 | 259230 | RNAseq | -0.0754 | 0.1631 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SGMS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGMS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGMS1 | 259230 | 3 | 5 | 22 | |
| GSE20123 | SGMS1 | 259230 | 3 | 5 | 22 | |
| GSE43470 | SGMS1 | 259230 | 2 | 6 | 35 | |
| GSE46452 | SGMS1 | 259230 | 0 | 13 | 46 | |
| GSE47630 | SGMS1 | 259230 | 4 | 12 | 24 | |
| GSE54993 | SGMS1 | 259230 | 9 | 0 | 61 | |
| GSE54994 | SGMS1 | 259230 | 2 | 10 | 41 | |
| GSE60625 | SGMS1 | 259230 | 0 | 0 | 11 | |
| GSE74703 | SGMS1 | 259230 | 2 | 3 | 31 | |
| GSE74704 | SGMS1 | 259230 | 1 | 4 | 15 | |
| TCGA | SGMS1 | 259230 | 13 | 22 | 61 |
Total number of gains: 39; Total number of losses: 80; Total Number of normals: 369.
Somatic mutations of SGMS1:
Generating mutation plots.
Highly correlated genes for SGMS1:
Showing top 20/566 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGMS1 | RNF13 | 0.805831 | 3 | 0 | 3 |
| SGMS1 | WDFY1 | 0.794743 | 3 | 0 | 3 |
| SGMS1 | XRCC5 | 0.786011 | 3 | 0 | 3 |
| SGMS1 | CUL3 | 0.772371 | 3 | 0 | 3 |
| SGMS1 | CRNKL1 | 0.771542 | 3 | 0 | 3 |
| SGMS1 | DR1 | 0.767431 | 3 | 0 | 3 |
| SGMS1 | POLR3C | 0.759719 | 3 | 0 | 3 |
| SGMS1 | ANAPC10 | 0.756508 | 3 | 0 | 3 |
| SGMS1 | FOXN3 | 0.75446 | 3 | 0 | 3 |
| SGMS1 | ACSL3 | 0.753907 | 3 | 0 | 3 |
| SGMS1 | UGP2 | 0.749094 | 3 | 0 | 3 |
| SGMS1 | CNOT7 | 0.747081 | 3 | 0 | 3 |
| SGMS1 | NPHP3 | 0.745348 | 3 | 0 | 3 |
| SGMS1 | IMPACT | 0.742604 | 4 | 0 | 3 |
| SGMS1 | FNIP1 | 0.742226 | 3 | 0 | 3 |
| SGMS1 | BBS7 | 0.738872 | 3 | 0 | 3 |
| SGMS1 | MOB4 | 0.737985 | 3 | 0 | 3 |
| SGMS1 | IFT74 | 0.736565 | 3 | 0 | 3 |
| SGMS1 | DALRD3 | 0.735862 | 3 | 0 | 3 |
| SGMS1 | UBA2 | 0.733726 | 3 | 0 | 3 |
For details and further investigation, click here
