HAUS3

 

Full name: HAUS augmin like complex subunit 3 Alias Symbol: MGC4701|IT1|dgt3
Type: protein-coding gene Cytoband: 4p16.3
Entrez ID: 79441 HGNC ID: HGNC:28719 Ensembl Gene: ENSG00000214367 OMIM ID: 613430
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HAUS3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HAUS3 79441 210054_at 0.3247 0.4150
GSE20347 HAUS3 79441 210054_at 0.1617 0.3249
GSE23400 HAUS3 79441 210054_at 0.2489 0.0000
GSE26886 HAUS3 79441 210054_at 0.2948 0.4002
GSE29001 HAUS3 79441 210054_at 0.1944 0.7000
GSE38129 HAUS3 79441 210054_at 0.2473 0.0187
GSE45670 HAUS3 79441 210054_at 0.0405 0.7713
GSE53622 HAUS3 79441 43205 -0.4656 0.0000
GSE53624 HAUS3 79441 43205 -0.1135 0.2132
GSE63941 HAUS3 79441 210054_at 0.6700 0.0955
GSE77861 HAUS3 79441 210054_at 0.1950 0.4856
GSE97050 HAUS3 79441 A_33_P3385062 -0.0179 0.9387
SRP007169 HAUS3 79441 RNAseq 0.0888 0.8508
SRP008496 HAUS3 79441 RNAseq -0.1000 0.7054
SRP064894 HAUS3 79441 RNAseq 0.1273 0.5563
SRP133303 HAUS3 79441 RNAseq 0.0358 0.6944
SRP159526 HAUS3 79441 RNAseq -0.0692 0.6863
SRP193095 HAUS3 79441 RNAseq -0.1628 0.0440
SRP219564 HAUS3 79441 RNAseq 0.0084 0.9818
TCGA HAUS3 79441 RNAseq -0.0188 0.7437

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by HAUS3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HAUS3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HAUS3 79441 0 16 14
GSE20123 HAUS3 79441 0 16 14
GSE43470 HAUS3 79441 0 17 26
GSE46452 HAUS3 79441 1 36 22
GSE47630 HAUS3 79441 1 19 20
GSE54993 HAUS3 79441 11 0 59
GSE54994 HAUS3 79441 3 12 38
GSE60625 HAUS3 79441 0 0 11
GSE74703 HAUS3 79441 0 13 23
GSE74704 HAUS3 79441 0 8 12
TCGA HAUS3 79441 9 47 40

Total number of gains: 25; Total number of losses: 184; Total Number of normals: 279.  

 

Somatic mutations of HAUS3:

 

Generating mutation plots.

 

Highly correlated genes for HAUS3:

 

Showing top 20/130 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HAUS3SLC22A50.70202404
HAUS3CEBPZ0.698051403
HAUS3NUFIP10.683493303
HAUS3GTPBP80.650979303
HAUS3CCDC1500.641088303
HAUS3MZT10.628447404
HAUS3KMT2A0.627127303
HAUS3ZNF6230.625747403
HAUS3HMMR-AS10.618374303
HAUS3TSNAX0.613928404
HAUS3STIM20.610621505
HAUS3SETD60.61043404
HAUS3PIGG0.608829907
HAUS3SPTSSA0.606865403
HAUS3ORMDL10.606509303
HAUS3EIF5B0.605774303
HAUS3SYNJ10.602353404
HAUS3YY10.601915403
HAUS3PRPF40A0.600728503
HAUS3MCTP20.59948504

For details and further investigation, click here