| Full name: ORMDL sphingolipid biosynthesis regulator 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 94101 | HGNC ID: HGNC:16036 | Ensembl Gene: ENSG00000128699 | OMIM ID: 610073 |
| Drug and gene relationship at DGIdb | |||
Expression of ORMDL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORMDL1 | 94101 | 223187_s_at | 0.3100 | 0.3040 | |
| GSE26886 | ORMDL1 | 94101 | 223187_s_at | -0.1399 | 0.6249 | |
| GSE45670 | ORMDL1 | 94101 | 223187_s_at | -0.0622 | 0.6792 | |
| GSE53622 | ORMDL1 | 94101 | 48176 | 0.4290 | 0.0000 | |
| GSE53624 | ORMDL1 | 94101 | 48176 | 0.4464 | 0.0000 | |
| GSE63941 | ORMDL1 | 94101 | 223187_s_at | -0.3515 | 0.3699 | |
| GSE77861 | ORMDL1 | 94101 | 223187_s_at | 0.1382 | 0.4043 | |
| GSE97050 | ORMDL1 | 94101 | A_23_P120194 | 0.1581 | 0.5887 | |
| SRP007169 | ORMDL1 | 94101 | RNAseq | 0.2471 | 0.5175 | |
| SRP008496 | ORMDL1 | 94101 | RNAseq | 0.4625 | 0.0396 | |
| SRP064894 | ORMDL1 | 94101 | RNAseq | 0.1559 | 0.2617 | |
| SRP133303 | ORMDL1 | 94101 | RNAseq | 0.1719 | 0.1758 | |
| SRP159526 | ORMDL1 | 94101 | RNAseq | 0.1034 | 0.6002 | |
| SRP193095 | ORMDL1 | 94101 | RNAseq | -0.0758 | 0.4699 | |
| SRP219564 | ORMDL1 | 94101 | RNAseq | -0.1092 | 0.6692 | |
| TCGA | ORMDL1 | 94101 | RNAseq | -0.0505 | 0.3345 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ORMDL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ORMDL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORMDL1 | 94101 | 9 | 3 | 18 | |
| GSE20123 | ORMDL1 | 94101 | 9 | 3 | 18 | |
| GSE43470 | ORMDL1 | 94101 | 3 | 1 | 39 | |
| GSE46452 | ORMDL1 | 94101 | 1 | 4 | 54 | |
| GSE47630 | ORMDL1 | 94101 | 4 | 5 | 31 | |
| GSE54993 | ORMDL1 | 94101 | 0 | 5 | 65 | |
| GSE54994 | ORMDL1 | 94101 | 12 | 6 | 35 | |
| GSE60625 | ORMDL1 | 94101 | 0 | 3 | 8 | |
| GSE74703 | ORMDL1 | 94101 | 2 | 1 | 33 | |
| GSE74704 | ORMDL1 | 94101 | 3 | 3 | 14 | |
| TCGA | ORMDL1 | 94101 | 24 | 7 | 65 |
Total number of gains: 67; Total number of losses: 41; Total Number of normals: 380.
Somatic mutations of ORMDL1:
Generating mutation plots.
Highly correlated genes for ORMDL1:
Showing top 20/93 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORMDL1 | TAP1 | 0.693535 | 3 | 0 | 3 |
| ORMDL1 | PMS1 | 0.668464 | 8 | 0 | 8 |
| ORMDL1 | HAT1 | 0.62593 | 4 | 0 | 4 |
| ORMDL1 | PRKRA | 0.615058 | 5 | 0 | 3 |
| ORMDL1 | DHRSX | 0.613745 | 4 | 0 | 3 |
| ORMDL1 | TRMT2A | 0.609303 | 3 | 0 | 3 |
| ORMDL1 | TFDP1 | 0.608876 | 3 | 0 | 3 |
| ORMDL1 | HAUS3 | 0.606509 | 3 | 0 | 3 |
| ORMDL1 | ASNSD1 | 0.598778 | 8 | 0 | 5 |
| ORMDL1 | LHX2 | 0.591164 | 3 | 0 | 3 |
| ORMDL1 | SNRPE | 0.589215 | 3 | 0 | 3 |
| ORMDL1 | STARD3 | 0.588464 | 4 | 0 | 3 |
| ORMDL1 | MIR3682 | 0.58329 | 3 | 0 | 3 |
| ORMDL1 | MS4A14 | 0.582543 | 3 | 0 | 3 |
| ORMDL1 | NAT10 | 0.581261 | 3 | 0 | 3 |
| ORMDL1 | VMA21 | 0.578063 | 4 | 0 | 3 |
| ORMDL1 | NOP2 | 0.575333 | 5 | 0 | 4 |
| ORMDL1 | TGFBRAP1 | 0.568514 | 4 | 0 | 3 |
| ORMDL1 | RBM45 | 0.567277 | 5 | 0 | 3 |
| ORMDL1 | SSH2 | 0.565001 | 3 | 0 | 3 |
For details and further investigation, click here
