| Full name: pre-mRNA processing factor 40 homolog A | Alias Symbol: FLJ20585|FBP11|HYPA|NY-REN-6|HIP10|FBP-11|FLAF1|Prp40 | ||
| Type: protein-coding gene | Cytoband: 2q23.3 | ||
| Entrez ID: 55660 | HGNC ID: HGNC:16463 | Ensembl Gene: ENSG00000196504 | OMIM ID: 612941 |
| Drug and gene relationship at DGIdb | |||
Expression of PRPF40A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPF40A | 55660 | 218053_at | 0.6332 | 0.0676 | |
| GSE20347 | PRPF40A | 55660 | 218053_at | 0.3450 | 0.0007 | |
| GSE23400 | PRPF40A | 55660 | 213729_at | 0.3658 | 0.0002 | |
| GSE26886 | PRPF40A | 55660 | 218053_at | 0.5386 | 0.0038 | |
| GSE29001 | PRPF40A | 55660 | 218053_at | 0.2414 | 0.3862 | |
| GSE38129 | PRPF40A | 55660 | 218053_at | 0.4742 | 0.0085 | |
| GSE45670 | PRPF40A | 55660 | 218053_at | 0.3394 | 0.0099 | |
| GSE53622 | PRPF40A | 55660 | 55547 | 0.3045 | 0.0000 | |
| GSE53624 | PRPF40A | 55660 | 55547 | 0.5271 | 0.0000 | |
| GSE63941 | PRPF40A | 55660 | 218053_at | -0.3055 | 0.3172 | |
| GSE77861 | PRPF40A | 55660 | 218053_at | 0.5050 | 0.0068 | |
| GSE97050 | PRPF40A | 55660 | A_23_P16762 | 0.2579 | 0.4969 | |
| SRP007169 | PRPF40A | 55660 | RNAseq | 0.3518 | 0.2933 | |
| SRP008496 | PRPF40A | 55660 | RNAseq | 0.6237 | 0.0002 | |
| SRP064894 | PRPF40A | 55660 | RNAseq | 0.1603 | 0.4527 | |
| SRP133303 | PRPF40A | 55660 | RNAseq | 0.4394 | 0.0036 | |
| SRP159526 | PRPF40A | 55660 | RNAseq | 0.1933 | 0.2213 | |
| SRP193095 | PRPF40A | 55660 | RNAseq | 0.0235 | 0.8103 | |
| SRP219564 | PRPF40A | 55660 | RNAseq | -0.0199 | 0.9490 | |
| TCGA | PRPF40A | 55660 | RNAseq | 0.1088 | 0.0093 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRPF40A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPF40A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPF40A | 55660 | 3 | 2 | 25 | |
| GSE20123 | PRPF40A | 55660 | 3 | 2 | 25 | |
| GSE43470 | PRPF40A | 55660 | 3 | 1 | 39 | |
| GSE46452 | PRPF40A | 55660 | 1 | 4 | 54 | |
| GSE47630 | PRPF40A | 55660 | 5 | 3 | 32 | |
| GSE54993 | PRPF40A | 55660 | 0 | 5 | 65 | |
| GSE54994 | PRPF40A | 55660 | 11 | 2 | 40 | |
| GSE60625 | PRPF40A | 55660 | 0 | 3 | 8 | |
| GSE74703 | PRPF40A | 55660 | 2 | 1 | 33 | |
| GSE74704 | PRPF40A | 55660 | 2 | 0 | 18 | |
| TCGA | PRPF40A | 55660 | 21 | 8 | 67 |
Total number of gains: 51; Total number of losses: 31; Total Number of normals: 406.
Somatic mutations of PRPF40A:
Generating mutation plots.
Highly correlated genes for PRPF40A:
Showing top 20/1403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPF40A | VRK2 | 0.77639 | 6 | 0 | 6 |
| PRPF40A | ANAPC1 | 0.765016 | 3 | 0 | 3 |
| PRPF40A | NOP58 | 0.750854 | 7 | 0 | 7 |
| PRPF40A | DKC1 | 0.740734 | 3 | 0 | 3 |
| PRPF40A | NIFK | 0.735245 | 6 | 0 | 6 |
| PRPF40A | PNPT1 | 0.731425 | 7 | 0 | 7 |
| PRPF40A | GDF5 | 0.729625 | 3 | 0 | 3 |
| PRPF40A | SFR1 | 0.725816 | 4 | 0 | 4 |
| PRPF40A | ZNF680 | 0.72427 | 3 | 0 | 3 |
| PRPF40A | EBNA1BP2 | 0.720843 | 3 | 0 | 3 |
| PRPF40A | SAP30L | 0.720284 | 3 | 0 | 3 |
| PRPF40A | SEC61A2 | 0.711874 | 3 | 0 | 3 |
| PRPF40A | NUF2 | 0.711322 | 7 | 0 | 7 |
| PRPF40A | DHX40 | 0.708509 | 3 | 0 | 3 |
| PRPF40A | WDR43 | 0.705006 | 11 | 0 | 10 |
| PRPF40A | SSB | 0.698692 | 11 | 0 | 11 |
| PRPF40A | SLC41A1 | 0.695827 | 5 | 0 | 5 |
| PRPF40A | DBR1 | 0.695223 | 5 | 0 | 4 |
| PRPF40A | ANAPC10 | 0.694788 | 5 | 0 | 5 |
| PRPF40A | ITGB8 | 0.693044 | 3 | 0 | 3 |
For details and further investigation, click here
