| Full name: serine palmitoyltransferase small subunit A | Alias Symbol: ssSPTa | ||
| Type: protein-coding gene | Cytoband: 14q13.1 | ||
| Entrez ID: 171546 | HGNC ID: HGNC:20361 | Ensembl Gene: ENSG00000165389 | OMIM ID: 613540 |
Screen Evidence:
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Expression of SPTSSA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTSSA | 171546 | 212460_at | 0.9455 | 0.1110 | |
| GSE20347 | SPTSSA | 171546 | 213508_at | 0.1845 | 0.5746 | |
| GSE23400 | SPTSSA | 171546 | 212460_at | 0.6515 | 0.0000 | |
| GSE26886 | SPTSSA | 171546 | 212460_at | 0.1861 | 0.6246 | |
| GSE29001 | SPTSSA | 171546 | 212460_at | 0.9294 | 0.0200 | |
| GSE38129 | SPTSSA | 171546 | 213508_at | -0.0719 | 0.7613 | |
| GSE45670 | SPTSSA | 171546 | 212460_at | 0.7051 | 0.0082 | |
| GSE53622 | SPTSSA | 171546 | 88262 | 0.5508 | 0.0000 | |
| GSE53624 | SPTSSA | 171546 | 88262 | 0.7400 | 0.0000 | |
| GSE63941 | SPTSSA | 171546 | 212460_at | 0.5272 | 0.3847 | |
| GSE77861 | SPTSSA | 171546 | 212460_at | 1.0088 | 0.0185 | |
| GSE97050 | SPTSSA | 171546 | A_33_P3307875 | -0.1977 | 0.3442 | |
| SRP007169 | SPTSSA | 171546 | RNAseq | 0.6022 | 0.1757 | |
| SRP008496 | SPTSSA | 171546 | RNAseq | 0.9835 | 0.0010 | |
| SRP064894 | SPTSSA | 171546 | RNAseq | 0.3637 | 0.0496 | |
| SRP133303 | SPTSSA | 171546 | RNAseq | 0.9069 | 0.0002 | |
| SRP159526 | SPTSSA | 171546 | RNAseq | 0.8785 | 0.0601 | |
| SRP193095 | SPTSSA | 171546 | RNAseq | 0.3457 | 0.0559 | |
| SRP219564 | SPTSSA | 171546 | RNAseq | 1.4220 | 0.0120 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPTSSA expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPTSSA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTSSA | 171546 | 10 | 4 | 16 | |
| GSE20123 | SPTSSA | 171546 | 11 | 4 | 15 | |
| GSE43470 | SPTSSA | 171546 | 9 | 2 | 32 | |
| GSE46452 | SPTSSA | 171546 | 18 | 2 | 39 | |
| GSE47630 | SPTSSA | 171546 | 11 | 10 | 19 | |
| GSE54993 | SPTSSA | 171546 | 3 | 10 | 57 | |
| GSE54994 | SPTSSA | 171546 | 19 | 5 | 29 | |
| GSE60625 | SPTSSA | 171546 | 0 | 2 | 9 | |
| GSE74703 | SPTSSA | 171546 | 8 | 2 | 26 | |
| GSE74704 | SPTSSA | 171546 | 5 | 3 | 12 | |
| TCGA | SPTSSA | 171546 | 32 | 14 | 50 |
Total number of gains: 126; Total number of losses: 58; Total Number of normals: 304.
Somatic mutations of SPTSSA:
Generating mutation plots.
Highly correlated genes for SPTSSA:
Showing top 20/1034 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTSSA | PIGU | 0.762724 | 3 | 0 | 3 |
| SPTSSA | MRPL45 | 0.758311 | 3 | 0 | 3 |
| SPTSSA | C1orf226 | 0.720405 | 4 | 0 | 4 |
| SPTSSA | EXOC6 | 0.712683 | 3 | 0 | 3 |
| SPTSSA | RSRC1 | 0.711433 | 6 | 0 | 6 |
| SPTSSA | IWS1 | 0.710957 | 5 | 0 | 5 |
| SPTSSA | DHTKD1 | 0.706363 | 3 | 0 | 3 |
| SPTSSA | YWHAG | 0.703502 | 5 | 0 | 5 |
| SPTSSA | ZNF114 | 0.700995 | 3 | 0 | 3 |
| SPTSSA | LATS1 | 0.696706 | 3 | 0 | 3 |
| SPTSSA | MRPS5 | 0.696474 | 5 | 0 | 4 |
| SPTSSA | CLASP1 | 0.695756 | 3 | 0 | 3 |
| SPTSSA | ZFHX3 | 0.693536 | 3 | 0 | 3 |
| SPTSSA | CEBPZ | 0.69173 | 6 | 0 | 6 |
| SPTSSA | PCBP2 | 0.691652 | 3 | 0 | 3 |
| SPTSSA | SLC39A1 | 0.689308 | 4 | 0 | 3 |
| SPTSSA | SCYL1 | 0.689035 | 4 | 0 | 4 |
| SPTSSA | HNRNPU | 0.687322 | 5 | 0 | 4 |
| SPTSSA | U2SURP | 0.6831 | 6 | 0 | 6 |
| SPTSSA | ATF4 | 0.682811 | 3 | 0 | 3 |
For details and further investigation, click here
