| Full name: solute carrier family 22 member 5 | Alias Symbol: OCTN2|SCD | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 6584 | HGNC ID: HGNC:10969 | Ensembl Gene: ENSG00000197375 | OMIM ID: 603377 |
| Drug and gene relationship at DGIdb | |||
SLC22A5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of SLC22A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A5 | 6584 | 205074_at | 0.6648 | 0.3617 | |
| GSE20347 | SLC22A5 | 6584 | 205074_at | 0.0883 | 0.5458 | |
| GSE23400 | SLC22A5 | 6584 | 205074_at | 0.0467 | 0.3107 | |
| GSE26886 | SLC22A5 | 6584 | 205074_at | 0.2784 | 0.3827 | |
| GSE29001 | SLC22A5 | 6584 | 205074_at | 0.0196 | 0.9672 | |
| GSE38129 | SLC22A5 | 6584 | 205074_at | -0.0082 | 0.9519 | |
| GSE45670 | SLC22A5 | 6584 | 205074_at | -0.0471 | 0.8582 | |
| GSE53622 | SLC22A5 | 6584 | 147477 | -0.0219 | 0.8125 | |
| GSE53624 | SLC22A5 | 6584 | 147477 | -0.0515 | 0.5443 | |
| GSE63941 | SLC22A5 | 6584 | 205074_at | 0.4884 | 0.3144 | |
| GSE77861 | SLC22A5 | 6584 | 205074_at | 0.1806 | 0.3465 | |
| GSE97050 | SLC22A5 | 6584 | A_24_P174755 | -0.0611 | 0.8070 | |
| SRP007169 | SLC22A5 | 6584 | RNAseq | -0.4988 | 0.2158 | |
| SRP008496 | SLC22A5 | 6584 | RNAseq | -0.2999 | 0.3454 | |
| SRP064894 | SLC22A5 | 6584 | RNAseq | -0.1446 | 0.3342 | |
| SRP133303 | SLC22A5 | 6584 | RNAseq | 0.1209 | 0.5425 | |
| SRP159526 | SLC22A5 | 6584 | RNAseq | 0.0393 | 0.8914 | |
| SRP193095 | SLC22A5 | 6584 | RNAseq | -0.2021 | 0.2901 | |
| SRP219564 | SLC22A5 | 6584 | RNAseq | 0.3766 | 0.4323 | |
| TCGA | SLC22A5 | 6584 | RNAseq | -0.2776 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC22A5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A5 | 6584 | 1 | 11 | 18 | |
| GSE20123 | SLC22A5 | 6584 | 2 | 11 | 17 | |
| GSE43470 | SLC22A5 | 6584 | 2 | 9 | 32 | |
| GSE46452 | SLC22A5 | 6584 | 0 | 27 | 32 | |
| GSE47630 | SLC22A5 | 6584 | 0 | 21 | 19 | |
| GSE54993 | SLC22A5 | 6584 | 9 | 1 | 60 | |
| GSE54994 | SLC22A5 | 6584 | 2 | 14 | 37 | |
| GSE60625 | SLC22A5 | 6584 | 0 | 0 | 11 | |
| GSE74703 | SLC22A5 | 6584 | 2 | 6 | 28 | |
| GSE74704 | SLC22A5 | 6584 | 1 | 5 | 14 | |
| TCGA | SLC22A5 | 6584 | 3 | 39 | 54 |
Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.
Somatic mutations of SLC22A5:
Generating mutation plots.
Highly correlated genes for SLC22A5:
Showing top 20/279 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A5 | SLC2A4RG | 0.807835 | 3 | 0 | 3 |
| SLC22A5 | ZNF623 | 0.790277 | 3 | 0 | 3 |
| SLC22A5 | UTP23 | 0.786464 | 3 | 0 | 3 |
| SLC22A5 | GATAD2B | 0.785336 | 3 | 0 | 3 |
| SLC22A5 | GZF1 | 0.772911 | 3 | 0 | 3 |
| SLC22A5 | BSDC1 | 0.769085 | 3 | 0 | 3 |
| SLC22A5 | POU2F1 | 0.762866 | 3 | 0 | 3 |
| SLC22A5 | DENND4B | 0.76039 | 3 | 0 | 3 |
| SLC22A5 | ANAPC4 | 0.760363 | 4 | 0 | 4 |
| SLC22A5 | FJX1 | 0.752981 | 3 | 0 | 3 |
| SLC22A5 | PDHX | 0.747246 | 3 | 0 | 3 |
| SLC22A5 | NUFIP1 | 0.733164 | 4 | 0 | 4 |
| SLC22A5 | MRFAP1 | 0.727756 | 3 | 0 | 3 |
| SLC22A5 | GTF2F2 | 0.727754 | 3 | 0 | 3 |
| SLC22A5 | RICTOR | 0.725461 | 3 | 0 | 3 |
| SLC22A5 | ZMIZ2 | 0.724119 | 4 | 0 | 4 |
| SLC22A5 | HS6ST1 | 0.718169 | 3 | 0 | 3 |
| SLC22A5 | NVL | 0.717459 | 3 | 0 | 3 |
| SLC22A5 | NCAPG | 0.717147 | 3 | 0 | 3 |
| SLC22A5 | KRTCAP2 | 0.71451 | 3 | 0 | 3 |
For details and further investigation, click here
