| Full name: SET domain containing 6, protein lysine methyltransferase | Alias Symbol: FLJ21148 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 79918 | HGNC ID: HGNC:26116 | Ensembl Gene: ENSG00000103037 | OMIM ID: 616424 |
| Drug and gene relationship at DGIdb | |||
Expression of SETD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SETD6 | 79918 | 1554555_a_at | 0.3168 | 0.6252 | |
| GSE20347 | SETD6 | 79918 | 219751_at | 0.1629 | 0.4876 | |
| GSE23400 | SETD6 | 79918 | 219751_at | 0.2193 | 0.0003 | |
| GSE26886 | SETD6 | 79918 | 219751_at | -0.2414 | 0.5576 | |
| GSE29001 | SETD6 | 79918 | 219751_at | 0.2686 | 0.3625 | |
| GSE38129 | SETD6 | 79918 | 219751_at | 0.2105 | 0.2942 | |
| GSE45670 | SETD6 | 79918 | 1554555_a_at | 0.0661 | 0.6876 | |
| GSE53622 | SETD6 | 79918 | 59063 | -0.0426 | 0.5952 | |
| GSE53624 | SETD6 | 79918 | 59063 | -0.0592 | 0.4712 | |
| GSE63941 | SETD6 | 79918 | 1554555_a_at | 0.8051 | 0.2761 | |
| GSE77861 | SETD6 | 79918 | 1554555_a_at | 0.3328 | 0.1367 | |
| GSE97050 | SETD6 | 79918 | A_23_P129358 | -0.2900 | 0.2495 | |
| SRP007169 | SETD6 | 79918 | RNAseq | 0.5819 | 0.2712 | |
| SRP008496 | SETD6 | 79918 | RNAseq | 0.6379 | 0.0875 | |
| SRP064894 | SETD6 | 79918 | RNAseq | -0.1779 | 0.2439 | |
| SRP133303 | SETD6 | 79918 | RNAseq | -0.0806 | 0.6369 | |
| SRP159526 | SETD6 | 79918 | RNAseq | 0.6004 | 0.1190 | |
| SRP193095 | SETD6 | 79918 | RNAseq | -0.0853 | 0.4866 | |
| SRP219564 | SETD6 | 79918 | RNAseq | 0.0551 | 0.8954 | |
| TCGA | SETD6 | 79918 | RNAseq | 0.0037 | 0.9600 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SETD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SETD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SETD6 | 79918 | 7 | 0 | 23 | |
| GSE20123 | SETD6 | 79918 | 7 | 0 | 23 | |
| GSE43470 | SETD6 | 79918 | 2 | 7 | 34 | |
| GSE46452 | SETD6 | 79918 | 38 | 1 | 20 | |
| GSE47630 | SETD6 | 79918 | 10 | 8 | 22 | |
| GSE54993 | SETD6 | 79918 | 2 | 4 | 64 | |
| GSE54994 | SETD6 | 79918 | 6 | 10 | 37 | |
| GSE60625 | SETD6 | 79918 | 4 | 0 | 7 | |
| GSE74703 | SETD6 | 79918 | 2 | 5 | 29 | |
| GSE74704 | SETD6 | 79918 | 5 | 0 | 15 | |
| TCGA | SETD6 | 79918 | 26 | 11 | 59 |
Total number of gains: 109; Total number of losses: 46; Total Number of normals: 333.
Somatic mutations of SETD6:
Generating mutation plots.
Highly correlated genes for SETD6:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SETD6 | MRPS9 | 0.786386 | 3 | 0 | 3 |
| SETD6 | UTP23 | 0.769996 | 3 | 0 | 3 |
| SETD6 | ANAPC4 | 0.764991 | 3 | 0 | 3 |
| SETD6 | THADA | 0.745356 | 3 | 0 | 3 |
| SETD6 | EEF1D | 0.745011 | 3 | 0 | 3 |
| SETD6 | SURF6 | 0.733873 | 3 | 0 | 3 |
| SETD6 | HARS2 | 0.720163 | 3 | 0 | 3 |
| SETD6 | MSTO1 | 0.716493 | 3 | 0 | 3 |
| SETD6 | GLRX2 | 0.71337 | 4 | 0 | 3 |
| SETD6 | ASXL2 | 0.707945 | 3 | 0 | 3 |
| SETD6 | NOP58 | 0.704635 | 4 | 0 | 3 |
| SETD6 | GPN3 | 0.702711 | 3 | 0 | 3 |
| SETD6 | CCP110 | 0.700471 | 3 | 0 | 3 |
| SETD6 | RP9 | 0.694446 | 3 | 0 | 3 |
| SETD6 | RSF1 | 0.691948 | 3 | 0 | 3 |
| SETD6 | MRI1 | 0.690114 | 3 | 0 | 3 |
| SETD6 | ZNF706 | 0.689624 | 3 | 0 | 3 |
| SETD6 | OXNAD1 | 0.688826 | 3 | 0 | 3 |
| SETD6 | ARF1 | 0.684809 | 3 | 0 | 3 |
| SETD6 | PAIP1 | 0.68136 | 3 | 0 | 3 |
For details and further investigation, click here
