KMT2A

 

Full name: lysine methyltransferase 2A Alias Symbol: TRX1|HRX|ALL-1|HTRX1|CXXC7|MLL1A
Type: protein-coding gene Cytoband: 11q23.3
Entrez ID: 4297 HGNC ID: HGNC:7132 Ensembl Gene: ENSG00000118058 OMIM ID: 159555
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 19/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KMT2A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KMT2A 4297 212078_s_at -0.0581 0.9518
GSE20347 KMT2A 4297 212080_at -0.1588 0.3246
GSE23400 KMT2A 4297 212080_at -0.2968 0.0000
GSE26886 KMT2A 4297 226981_at 0.4308 0.0710
GSE29001 KMT2A 4297 212079_s_at 0.0393 0.9190
GSE38129 KMT2A 4297 212080_at -0.4579 0.0021
GSE45670 KMT2A 4297 226981_at -0.3874 0.0084
GSE53622 KMT2A 4297 4474 -0.2404 0.0001
GSE53624 KMT2A 4297 4474 -0.0016 0.9782
GSE63941 KMT2A 4297 226981_at -0.8503 0.0821
GSE77861 KMT2A 4297 212080_at 0.2461 0.3900
SRP007169 KMT2A 4297 RNAseq 0.6275 0.1649
SRP008496 KMT2A 4297 RNAseq 0.7941 0.0022
SRP064894 KMT2A 4297 RNAseq -0.3611 0.0998
SRP133303 KMT2A 4297 RNAseq -0.4058 0.0009
SRP159526 KMT2A 4297 RNAseq -0.4970 0.0670
SRP193095 KMT2A 4297 RNAseq -0.0907 0.3791
SRP219564 KMT2A 4297 RNAseq -0.3168 0.3034

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KMT2A expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of KMT2A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KMT2A 4297 2 11 17
GSE20123 KMT2A 4297 2 11 17
GSE43470 KMT2A 4297 2 9 32
GSE46452 KMT2A 4297 3 26 30
GSE47630 KMT2A 4297 2 19 19
GSE54993 KMT2A 4297 10 0 60
GSE54994 KMT2A 4297 5 19 29
GSE60625 KMT2A 4297 0 3 8
GSE74703 KMT2A 4297 1 6 29
GSE74704 KMT2A 4297 1 7 12
TCGA KMT2A 4297 5 50 41

Total number of gains: 33; Total number of losses: 161; Total Number of normals: 294.  

 

Somatic mutations of KMT2A:

 

Generating mutation plots.

 

Highly correlated genes for KMT2A:

 

Showing top 20/120 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KMT2APAFAH1B20.715603303
KMT2ASLC7A60.680369303
KMT2ADDHD20.643615404
KMT2AHAUS30.627127303
KMT2AZBTB210.612958403
KMT2AZBED60.612213303
KMT2AARHGEF120.609338505
KMT2AMSANTD20.608536907
KMT2APICALM0.606978303
KMT2AVPS110.606723907
KMT2APUS30.604296403
KMT2AZBTB400.603303
KMT2AWDR190.595267403
KMT2AKLF3-AS10.592362605
KMT2AKIAA11430.592043403
KMT2ARP90.591465303
KMT2ATHYN10.591306705
KMT2AMYO1C0.58647303
KMT2ATMEM2450.586345403
KMT2AOGG10.586088403

For details and further investigation, click here