| Full name: eukaryotic translation initiation factor 5B | Alias Symbol: IF2|KIAA0741|DKFZp434I036|FLJ10524 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 9669 | HGNC ID: HGNC:30793 | Ensembl Gene: ENSG00000158417 | OMIM ID: 606086 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF5B | 9669 | 201024_x_at | 0.2806 | 0.7190 | |
| GSE20347 | EIF5B | 9669 | 201024_x_at | 0.0419 | 0.8201 | |
| GSE23400 | EIF5B | 9669 | 201024_x_at | 0.1317 | 0.1697 | |
| GSE26886 | EIF5B | 9669 | 201024_x_at | 1.0236 | 0.0021 | |
| GSE29001 | EIF5B | 9669 | 201024_x_at | 0.1315 | 0.7303 | |
| GSE38129 | EIF5B | 9669 | 201024_x_at | 0.0807 | 0.7241 | |
| GSE45670 | EIF5B | 9669 | 201024_x_at | 0.4020 | 0.0074 | |
| GSE53622 | EIF5B | 9669 | 103977 | 0.0549 | 0.3863 | |
| GSE53624 | EIF5B | 9669 | 103977 | 0.2349 | 0.0022 | |
| GSE63941 | EIF5B | 9669 | 201024_x_at | -1.0578 | 0.0087 | |
| GSE77861 | EIF5B | 9669 | 201024_x_at | 0.4041 | 0.0321 | |
| GSE97050 | EIF5B | 9669 | A_23_P218608 | -0.0902 | 0.7089 | |
| SRP007169 | EIF5B | 9669 | RNAseq | 1.4543 | 0.0000 | |
| SRP008496 | EIF5B | 9669 | RNAseq | 1.6751 | 0.0000 | |
| SRP064894 | EIF5B | 9669 | RNAseq | 0.3060 | 0.1185 | |
| SRP133303 | EIF5B | 9669 | RNAseq | 0.2544 | 0.0657 | |
| SRP159526 | EIF5B | 9669 | RNAseq | 0.2046 | 0.5149 | |
| SRP193095 | EIF5B | 9669 | RNAseq | 0.0515 | 0.6787 | |
| SRP219564 | EIF5B | 9669 | RNAseq | -0.3250 | 0.4548 | |
| TCGA | EIF5B | 9669 | RNAseq | -0.0130 | 0.7753 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by EIF5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF5B | 9669 | 6 | 2 | 22 | |
| GSE20123 | EIF5B | 9669 | 6 | 2 | 22 | |
| GSE43470 | EIF5B | 9669 | 3 | 1 | 39 | |
| GSE46452 | EIF5B | 9669 | 2 | 3 | 54 | |
| GSE47630 | EIF5B | 9669 | 7 | 0 | 33 | |
| GSE54993 | EIF5B | 9669 | 0 | 6 | 64 | |
| GSE54994 | EIF5B | 9669 | 10 | 0 | 43 | |
| GSE60625 | EIF5B | 9669 | 0 | 3 | 8 | |
| GSE74703 | EIF5B | 9669 | 3 | 1 | 32 | |
| GSE74704 | EIF5B | 9669 | 4 | 1 | 15 | |
| TCGA | EIF5B | 9669 | 34 | 5 | 57 |
Total number of gains: 75; Total number of losses: 24; Total Number of normals: 389.
Somatic mutations of EIF5B:
Generating mutation plots.
Highly correlated genes for EIF5B:
Showing top 20/560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF5B | MRFAP1 | 0.831971 | 3 | 0 | 3 |
| EIF5B | THEM4 | 0.81084 | 3 | 0 | 3 |
| EIF5B | TOMM40L | 0.805221 | 3 | 0 | 3 |
| EIF5B | ZBED6 | 0.796669 | 3 | 0 | 3 |
| EIF5B | ARID2 | 0.786685 | 3 | 0 | 3 |
| EIF5B | ANAPC4 | 0.766313 | 3 | 0 | 3 |
| EIF5B | HMGXB4 | 0.762126 | 5 | 0 | 5 |
| EIF5B | COPS5 | 0.761458 | 3 | 0 | 3 |
| EIF5B | ATP11C | 0.756469 | 3 | 0 | 3 |
| EIF5B | PPHLN1 | 0.753724 | 4 | 0 | 4 |
| EIF5B | GPRASP1 | 0.753539 | 3 | 0 | 3 |
| EIF5B | NPHP3 | 0.742536 | 4 | 0 | 3 |
| EIF5B | SPCS3 | 0.736445 | 3 | 0 | 3 |
| EIF5B | KIAA0586 | 0.734378 | 3 | 0 | 3 |
| EIF5B | CCDC90B | 0.729194 | 3 | 0 | 3 |
| EIF5B | HMGB1 | 0.728785 | 3 | 0 | 3 |
| EIF5B | MRPS21 | 0.726385 | 3 | 0 | 3 |
| EIF5B | ALKBH6 | 0.725853 | 4 | 0 | 4 |
| EIF5B | PSMC3IP | 0.722408 | 3 | 0 | 3 |
| EIF5B | PPIG | 0.722358 | 9 | 0 | 8 |
For details and further investigation, click here
