HCLS1

 

Full name: hematopoietic cell-specific Lyn substrate 1 Alias Symbol: HS1|CTTNL
Type: protein-coding gene Cytoband: 3q13.33
Entrez ID: 3059 HGNC ID: HGNC:4844 Ensembl Gene: ENSG00000180353 OMIM ID: 601306
Drug and gene relationship at DGIdb

 

HCLS1 involved pathways:

KEGG pathway Description View
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
hsa05205Proteoglycans in cancer

 

Expression of HCLS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HCLS1 3059 202957_at 0.4344 0.7768
GSE20347 HCLS1 3059 202957_at -0.0277 0.9336
GSE23400 HCLS1 3059 202957_at 0.3245 0.0327
GSE26886 HCLS1 3059 202957_at -0.3721 0.5337
GSE29001 HCLS1 3059 202957_at 0.2164 0.5790
GSE38129 HCLS1 3059 202957_at 0.1106 0.7706
GSE45670 HCLS1 3059 202957_at -0.2432 0.5284
GSE53622 HCLS1 3059 116554 -0.0264 0.8463
GSE53624 HCLS1 3059 116554 -0.1731 0.2857
GSE63941 HCLS1 3059 202957_at 1.7989 0.4026
GSE77861 HCLS1 3059 202957_at 0.6219 0.2355
GSE97050 HCLS1 3059 A_23_P73429 0.7564 0.1726
SRP007169 HCLS1 3059 RNAseq 2.7239 0.0026
SRP064894 HCLS1 3059 RNAseq 0.8826 0.0032
SRP133303 HCLS1 3059 RNAseq 0.2169 0.2458
SRP159526 HCLS1 3059 RNAseq -0.2369 0.7432
SRP193095 HCLS1 3059 RNAseq 0.5184 0.0438
SRP219564 HCLS1 3059 RNAseq 0.8774 0.0646
TCGA HCLS1 3059 RNAseq 0.0775 0.5465

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by HCLS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HCLS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HCLS1 3059 18 0 12
GSE20123 HCLS1 3059 18 0 12
GSE43470 HCLS1 3059 20 0 23
GSE46452 HCLS1 3059 14 5 40
GSE47630 HCLS1 3059 16 5 19
GSE54993 HCLS1 3059 2 6 62
GSE54994 HCLS1 3059 30 4 19
GSE60625 HCLS1 3059 0 6 5
GSE74703 HCLS1 3059 16 0 20
GSE74704 HCLS1 3059 13 0 7
TCGA HCLS1 3059 54 6 36

Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.  

 

Somatic mutations of HCLS1:

 

Generating mutation plots.

 

Highly correlated genes for HCLS1:

 

Showing top 20/412 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HCLS1C19orf380.775225303
HCLS1C1orf1620.772494605
HCLS1CORO1A0.75049211011
HCLS1TFIP110.745725303
HCLS1CD370.740574807
HCLS1EFTUD20.739134303
HCLS1SNX200.732725604
HCLS1CLEC12A0.731069404
HCLS1NEDD90.729477303
HCLS1CD530.728448908
HCLS1IRF80.72667211011
HCLS1EVI2B0.7260561109
HCLS1TNFSF80.725679504
HCLS1BTN2A20.725291303
HCLS1ARHGAP90.724892707
HCLS1PARVG0.718681605
HCLS1DOCK20.7157711009
HCLS1CERKL0.715487303
HCLS1GPR1320.708427404
HCLS1PRR130.706722404

For details and further investigation, click here