| Full name: CD53 molecule | Alias Symbol: TSPAN25 | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 963 | HGNC ID: HGNC:1686 | Ensembl Gene: ENSG00000143119 | OMIM ID: 151525 |
| Drug and gene relationship at DGIdb | |||
Expression of CD53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD53 | 963 | 203416_at | 0.5225 | 0.7546 | |
| GSE20347 | CD53 | 963 | 203416_at | 0.2410 | 0.3297 | |
| GSE23400 | CD53 | 963 | 203416_at | 0.3379 | 0.0030 | |
| GSE26886 | CD53 | 963 | 203416_at | -0.7061 | 0.1447 | |
| GSE29001 | CD53 | 963 | 203416_at | 0.4445 | 0.1540 | |
| GSE38129 | CD53 | 963 | 203416_at | 0.2768 | 0.3433 | |
| GSE45670 | CD53 | 963 | 203416_at | -0.2879 | 0.4109 | |
| GSE63941 | CD53 | 963 | 203416_at | 0.1204 | 0.4503 | |
| GSE77861 | CD53 | 963 | 203416_at | 0.1671 | 0.4875 | |
| GSE97050 | CD53 | 963 | A_23_P74547 | 0.9378 | 0.2211 | |
| SRP007169 | CD53 | 963 | RNAseq | 2.0844 | 0.0104 | |
| SRP008496 | CD53 | 963 | RNAseq | 1.5929 | 0.0015 | |
| SRP064894 | CD53 | 963 | RNAseq | 0.9503 | 0.0006 | |
| SRP133303 | CD53 | 963 | RNAseq | 0.3343 | 0.1695 | |
| SRP159526 | CD53 | 963 | RNAseq | -0.6569 | 0.4704 | |
| SRP193095 | CD53 | 963 | RNAseq | 0.5612 | 0.0226 | |
| SRP219564 | CD53 | 963 | RNAseq | 1.0824 | 0.0086 | |
| TCGA | CD53 | 963 | RNAseq | 0.1179 | 0.3510 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CD53 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD53 | 963 | 0 | 11 | 19 | |
| GSE20123 | CD53 | 963 | 0 | 11 | 19 | |
| GSE43470 | CD53 | 963 | 0 | 8 | 35 | |
| GSE46452 | CD53 | 963 | 2 | 1 | 56 | |
| GSE47630 | CD53 | 963 | 9 | 5 | 26 | |
| GSE54993 | CD53 | 963 | 0 | 1 | 69 | |
| GSE54994 | CD53 | 963 | 7 | 4 | 42 | |
| GSE60625 | CD53 | 963 | 0 | 0 | 11 | |
| GSE74703 | CD53 | 963 | 0 | 7 | 29 | |
| GSE74704 | CD53 | 963 | 0 | 7 | 13 | |
| TCGA | CD53 | 963 | 8 | 27 | 61 |
Total number of gains: 26; Total number of losses: 82; Total Number of normals: 380.
Somatic mutations of CD53:
Generating mutation plots.
Highly correlated genes for CD53:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD53 | PIK3R5 | 0.869642 | 3 | 0 | 3 |
| CD53 | LAPTM5 | 0.860144 | 10 | 0 | 9 |
| CD53 | EVI2B | 0.851135 | 10 | 0 | 10 |
| CD53 | ITGB2 | 0.831958 | 9 | 0 | 9 |
| CD53 | IRF8 | 0.816833 | 10 | 0 | 10 |
| CD53 | SLAMF6 | 0.815706 | 3 | 0 | 3 |
| CD53 | CYTIP | 0.807151 | 9 | 0 | 9 |
| CD53 | DOCK2 | 0.802476 | 8 | 0 | 8 |
| CD53 | APBB1IP | 0.787629 | 5 | 0 | 4 |
| CD53 | GMFG | 0.787371 | 9 | 0 | 9 |
| CD53 | CD84 | 0.785542 | 8 | 0 | 7 |
| CD53 | EVI2A | 0.781749 | 9 | 0 | 9 |
| CD53 | SRGN | 0.780648 | 10 | 0 | 10 |
| CD53 | SMAP2 | 0.779176 | 5 | 0 | 5 |
| CD53 | C16orf54 | 0.77232 | 4 | 0 | 3 |
| CD53 | TFEC | 0.772312 | 8 | 0 | 8 |
| CD53 | NCKAP1L | 0.770864 | 8 | 0 | 7 |
| CD53 | SLA | 0.763441 | 10 | 0 | 9 |
| CD53 | CD37 | 0.761452 | 7 | 0 | 6 |
| CD53 | SAMSN1 | 0.761114 | 11 | 0 | 10 |
For details and further investigation, click here
