| Full name: interferon regulatory factor 8 | Alias Symbol: IRF-8|ICSBP | ||
| Type: protein-coding gene | Cytoband: 16q24.1 | ||
| Entrez ID: 3394 | HGNC ID: HGNC:5358 | Ensembl Gene: ENSG00000140968 | OMIM ID: 601565 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IRF8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05133 | Pertussis |
Expression of IRF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF8 | 3394 | 204057_at | -0.2992 | 0.8316 | |
| GSE20347 | IRF8 | 3394 | 204057_at | 0.0358 | 0.8488 | |
| GSE23400 | IRF8 | 3394 | 204057_at | 0.0502 | 0.6380 | |
| GSE26886 | IRF8 | 3394 | 204057_at | -0.3474 | 0.3871 | |
| GSE29001 | IRF8 | 3394 | 204057_at | 0.3250 | 0.3742 | |
| GSE38129 | IRF8 | 3394 | 204057_at | -0.1983 | 0.4097 | |
| GSE45670 | IRF8 | 3394 | 204057_at | -0.3907 | 0.2062 | |
| GSE53622 | IRF8 | 3394 | 127032 | -0.2449 | 0.2780 | |
| GSE53624 | IRF8 | 3394 | 38707 | -0.6304 | 0.0019 | |
| GSE63941 | IRF8 | 3394 | 204057_at | 0.1883 | 0.5872 | |
| GSE77861 | IRF8 | 3394 | 204057_at | 0.1292 | 0.4826 | |
| GSE97050 | IRF8 | 3394 | A_33_P3343120 | 0.7302 | 0.1756 | |
| SRP007169 | IRF8 | 3394 | RNAseq | 1.4305 | 0.0740 | |
| SRP008496 | IRF8 | 3394 | RNAseq | 1.0425 | 0.0441 | |
| SRP064894 | IRF8 | 3394 | RNAseq | 0.6553 | 0.0457 | |
| SRP133303 | IRF8 | 3394 | RNAseq | -0.0034 | 0.9906 | |
| SRP159526 | IRF8 | 3394 | RNAseq | -1.0748 | 0.2677 | |
| SRP193095 | IRF8 | 3394 | RNAseq | 0.0711 | 0.8460 | |
| SRP219564 | IRF8 | 3394 | RNAseq | 1.3887 | 0.0200 | |
| TCGA | IRF8 | 3394 | RNAseq | -0.5334 | 0.0038 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IRF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF8 | 3394 | 4 | 4 | 22 | |
| GSE20123 | IRF8 | 3394 | 4 | 4 | 22 | |
| GSE43470 | IRF8 | 3394 | 2 | 10 | 31 | |
| GSE46452 | IRF8 | 3394 | 37 | 2 | 20 | |
| GSE47630 | IRF8 | 3394 | 11 | 9 | 20 | |
| GSE54993 | IRF8 | 3394 | 3 | 4 | 63 | |
| GSE54994 | IRF8 | 3394 | 9 | 10 | 34 | |
| GSE60625 | IRF8 | 3394 | 4 | 0 | 7 | |
| GSE74703 | IRF8 | 3394 | 1 | 7 | 28 | |
| GSE74704 | IRF8 | 3394 | 3 | 2 | 15 | |
| TCGA | IRF8 | 3394 | 26 | 16 | 54 |
Total number of gains: 104; Total number of losses: 68; Total Number of normals: 316.
Somatic mutations of IRF8:
Generating mutation plots.
Highly correlated genes for IRF8:
Showing top 20/531 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF8 | C16orf54 | 0.825023 | 6 | 0 | 6 |
| IRF8 | SLAMF6 | 0.818218 | 5 | 0 | 5 |
| IRF8 | CD53 | 0.816833 | 10 | 0 | 10 |
| IRF8 | GIMAP5 | 0.81592 | 4 | 0 | 4 |
| IRF8 | COL23A1 | 0.801926 | 3 | 0 | 3 |
| IRF8 | DOCK2 | 0.799109 | 10 | 0 | 10 |
| IRF8 | TNFSF8 | 0.797891 | 5 | 0 | 5 |
| IRF8 | C1orf162 | 0.796209 | 7 | 0 | 7 |
| IRF8 | NCKAP1L | 0.786262 | 10 | 0 | 10 |
| IRF8 | GIMAP7 | 0.779726 | 7 | 0 | 7 |
| IRF8 | GMFG | 0.774664 | 11 | 0 | 11 |
| IRF8 | EVI2B | 0.774579 | 12 | 0 | 11 |
| IRF8 | CD84 | 0.772055 | 9 | 0 | 9 |
| IRF8 | RCSD1 | 0.769639 | 7 | 0 | 7 |
| IRF8 | TAGAP | 0.76763 | 6 | 0 | 5 |
| IRF8 | MPEG1 | 0.763656 | 7 | 0 | 6 |
| IRF8 | ARHGAP15 | 0.762193 | 4 | 0 | 4 |
| IRF8 | ITK | 0.760313 | 10 | 0 | 10 |
| IRF8 | PPP1R16B | 0.756182 | 8 | 0 | 8 |
| IRF8 | CERKL | 0.755698 | 3 | 0 | 3 |
For details and further investigation, click here
