HDAC1

 

Full name: histone deacetylase 1 Alias Symbol: HD1|GON-10|KDAC1
Type: protein-coding gene Cytoband: 1p35.2-p35.1
Entrez ID: 3065 HGNC ID: HGNC:4852 Ensembl Gene: ENSG00000116478 OMIM ID: 601241
Drug and gene relationship at DGIdb
Screen Evidence:

 

HDAC1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04213Longevity regulating pathway - multiple species
hsa04330Notch signaling pathway
hsa05031Amphetamine addiction
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia

 

Expression of HDAC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HDAC1 3065 201209_at 0.3001 0.4812
GSE20347 HDAC1 3065 201209_at 0.2591 0.0252
GSE23400 HDAC1 3065 201209_at 0.3052 0.0002
GSE26886 HDAC1 3065 201209_at 0.3349 0.0773
GSE29001 HDAC1 3065 201209_at 0.2122 0.3529
GSE38129 HDAC1 3065 201209_at 0.4240 0.0013
GSE45670 HDAC1 3065 201209_at 0.6962 0.0001
GSE53622 HDAC1 3065 128839 0.3366 0.0000
GSE53624 HDAC1 3065 128839 0.5127 0.0000
GSE63941 HDAC1 3065 201209_at 1.1829 0.0136
GSE77861 HDAC1 3065 201209_at 0.4773 0.1611
GSE97050 HDAC1 3065 A_23_P114656 0.4399 0.1782
SRP007169 HDAC1 3065 RNAseq 0.4523 0.2830
SRP008496 HDAC1 3065 RNAseq 0.0459 0.8785
SRP064894 HDAC1 3065 RNAseq 0.4782 0.0081
SRP133303 HDAC1 3065 RNAseq 0.5381 0.0049
SRP159526 HDAC1 3065 RNAseq 0.2249 0.3707
SRP193095 HDAC1 3065 RNAseq 0.1373 0.2747
SRP219564 HDAC1 3065 RNAseq -0.3043 0.4190
TCGA HDAC1 3065 RNAseq 0.1478 0.0015

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by HDAC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HDAC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HDAC1 3065 1 5 24
GSE20123 HDAC1 3065 1 4 25
GSE43470 HDAC1 3065 6 4 33
GSE46452 HDAC1 3065 5 1 53
GSE47630 HDAC1 3065 8 3 29
GSE54993 HDAC1 3065 1 1 68
GSE54994 HDAC1 3065 11 2 40
GSE60625 HDAC1 3065 0 0 11
GSE74703 HDAC1 3065 4 3 29
GSE74704 HDAC1 3065 0 0 20
TCGA HDAC1 3065 10 20 66

Total number of gains: 47; Total number of losses: 43; Total Number of normals: 398.  

 

Somatic mutations of HDAC1:

 

Generating mutation plots.

 

Highly correlated genes for HDAC1:

 

Showing top 20/1141 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HDAC1ZNF7660.781573303
HDAC1TMEM167A0.77328303
HDAC1MCCC20.746372403
HDAC1SMAD10.737102504
HDAC1HPS40.731257403
HDAC1ARHGAP180.731131303
HDAC1PRELID10.72757303
HDAC1UEVLD0.726102303
HDAC1RNF1490.72533303
HDAC1ZNF6640.721897303
HDAC1SMC50.71355303
HDAC1MAPK90.712155303
HDAC1EBNA1BP20.710533303
HDAC1KTI120.709227303
HDAC1SLC30A70.707617404
HDAC1ATP6V1A0.707534403
HDAC1UNKL0.706038303
HDAC1FCHO10.704708303
HDAC1TMEM540.703867504
HDAC1PMPCB0.699403303

For details and further investigation, click here