| Full name: structural maintenance of chromosomes 5 | Alias Symbol: KIAA0594 | ||
| Type: protein-coding gene | Cytoband: 9q21.12 | ||
| Entrez ID: 23137 | HGNC ID: HGNC:20465 | Ensembl Gene: ENSG00000198887 | OMIM ID: 609386 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMC5 | 23137 | 212927_at | -0.0671 | 0.9011 | |
| GSE20347 | SMC5 | 23137 | 212927_at | -0.1886 | 0.2387 | |
| GSE23400 | SMC5 | 23137 | 212927_at | 0.0829 | 0.2288 | |
| GSE26886 | SMC5 | 23137 | 212927_at | 0.1280 | 0.6768 | |
| GSE29001 | SMC5 | 23137 | 212927_at | -0.1641 | 0.6067 | |
| GSE38129 | SMC5 | 23137 | 212927_at | -0.0211 | 0.8768 | |
| GSE45670 | SMC5 | 23137 | 212927_at | -0.1968 | 0.3469 | |
| GSE53622 | SMC5 | 23137 | 17544 | -0.1769 | 0.0206 | |
| GSE53624 | SMC5 | 23137 | 17544 | -0.1558 | 0.2401 | |
| GSE63941 | SMC5 | 23137 | 212927_at | -0.2163 | 0.7089 | |
| GSE77861 | SMC5 | 23137 | 212927_at | -0.0255 | 0.9364 | |
| GSE97050 | SMC5 | 23137 | A_32_P126609 | 0.0105 | 0.9770 | |
| SRP007169 | SMC5 | 23137 | RNAseq | 1.3040 | 0.0019 | |
| SRP008496 | SMC5 | 23137 | RNAseq | 1.3263 | 0.0000 | |
| SRP064894 | SMC5 | 23137 | RNAseq | -0.1265 | 0.6330 | |
| SRP133303 | SMC5 | 23137 | RNAseq | -0.0468 | 0.7740 | |
| SRP159526 | SMC5 | 23137 | RNAseq | -0.2808 | 0.3969 | |
| SRP193095 | SMC5 | 23137 | RNAseq | -0.1225 | 0.1989 | |
| SRP219564 | SMC5 | 23137 | RNAseq | -0.2185 | 0.5366 | |
| TCGA | SMC5 | 23137 | RNAseq | -0.1013 | 0.0683 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SMC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMC5 | 23137 | 6 | 10 | 14 | |
| GSE20123 | SMC5 | 23137 | 6 | 10 | 14 | |
| GSE43470 | SMC5 | 23137 | 6 | 5 | 32 | |
| GSE46452 | SMC5 | 23137 | 6 | 14 | 39 | |
| GSE47630 | SMC5 | 23137 | 1 | 19 | 20 | |
| GSE54993 | SMC5 | 23137 | 5 | 1 | 64 | |
| GSE54994 | SMC5 | 23137 | 4 | 13 | 36 | |
| GSE60625 | SMC5 | 23137 | 0 | 0 | 11 | |
| GSE74703 | SMC5 | 23137 | 5 | 4 | 27 | |
| GSE74704 | SMC5 | 23137 | 3 | 7 | 10 | |
| TCGA | SMC5 | 23137 | 19 | 28 | 49 |
Total number of gains: 61; Total number of losses: 111; Total Number of normals: 316.
Somatic mutations of SMC5:
Generating mutation plots.
Highly correlated genes for SMC5:
Showing top 20/227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMC5 | IER3IP1 | 0.780656 | 3 | 0 | 3 |
| SMC5 | CDYL | 0.779916 | 3 | 0 | 3 |
| SMC5 | WIPF2 | 0.773531 | 3 | 0 | 3 |
| SMC5 | WHAMM | 0.773216 | 3 | 0 | 3 |
| SMC5 | RER1 | 0.767223 | 3 | 0 | 3 |
| SMC5 | CASP8 | 0.76717 | 3 | 0 | 3 |
| SMC5 | ANKRD50 | 0.748007 | 3 | 0 | 3 |
| SMC5 | KCNJ2 | 0.746353 | 3 | 0 | 3 |
| SMC5 | PLEKHG1 | 0.736853 | 3 | 0 | 3 |
| SMC5 | ANKMY2 | 0.73225 | 4 | 0 | 4 |
| SMC5 | ARHGAP18 | 0.73055 | 3 | 0 | 3 |
| SMC5 | RNASEH2B | 0.726786 | 3 | 0 | 3 |
| SMC5 | CLDN12 | 0.717946 | 3 | 0 | 3 |
| SMC5 | ELK3 | 0.717439 | 3 | 0 | 3 |
| SMC5 | HDAC1 | 0.71355 | 3 | 0 | 3 |
| SMC5 | PAK2 | 0.712904 | 3 | 0 | 3 |
| SMC5 | REPS1 | 0.70926 | 3 | 0 | 3 |
| SMC5 | B3GNT7 | 0.70792 | 3 | 0 | 3 |
| SMC5 | HLA-DQB2 | 0.706441 | 3 | 0 | 3 |
| SMC5 | SLC10A7 | 0.706377 | 3 | 0 | 3 |
For details and further investigation, click here
