| Full name: Rho GTPase activating protein 18 | Alias Symbol: MacGAP|bA307O14.2 | ||
| Type: protein-coding gene | Cytoband: 6q22.33 | ||
| Entrez ID: 93663 | HGNC ID: HGNC:21035 | Ensembl Gene: ENSG00000146376 | OMIM ID: 613351 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGAP18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGAP18 | 93663 | 225171_at | 0.3798 | 0.4285 | |
| GSE26886 | ARHGAP18 | 93663 | 225171_at | 1.0429 | 0.0048 | |
| GSE45670 | ARHGAP18 | 93663 | 225171_at | -0.0354 | 0.8898 | |
| GSE53622 | ARHGAP18 | 93663 | 75247 | 0.2580 | 0.0708 | |
| GSE53624 | ARHGAP18 | 93663 | 75247 | 0.2885 | 0.0438 | |
| GSE63941 | ARHGAP18 | 93663 | 225171_at | -0.0838 | 0.9245 | |
| GSE77861 | ARHGAP18 | 93663 | 225171_at | 0.1302 | 0.5277 | |
| GSE97050 | ARHGAP18 | 93663 | A_32_P162250 | 0.7344 | 0.1628 | |
| SRP007169 | ARHGAP18 | 93663 | RNAseq | 1.6484 | 0.0025 | |
| SRP008496 | ARHGAP18 | 93663 | RNAseq | 1.6477 | 0.0001 | |
| SRP064894 | ARHGAP18 | 93663 | RNAseq | 0.6434 | 0.0116 | |
| SRP133303 | ARHGAP18 | 93663 | RNAseq | 0.5412 | 0.0006 | |
| SRP159526 | ARHGAP18 | 93663 | RNAseq | 0.1095 | 0.8032 | |
| SRP193095 | ARHGAP18 | 93663 | RNAseq | -0.0355 | 0.8984 | |
| SRP219564 | ARHGAP18 | 93663 | RNAseq | 1.0288 | 0.0367 | |
| TCGA | ARHGAP18 | 93663 | RNAseq | -0.5445 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ARHGAP18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGAP18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGAP18 | 93663 | 1 | 4 | 25 | |
| GSE20123 | ARHGAP18 | 93663 | 1 | 3 | 26 | |
| GSE43470 | ARHGAP18 | 93663 | 5 | 0 | 38 | |
| GSE46452 | ARHGAP18 | 93663 | 2 | 11 | 46 | |
| GSE47630 | ARHGAP18 | 93663 | 9 | 4 | 27 | |
| GSE54993 | ARHGAP18 | 93663 | 3 | 3 | 64 | |
| GSE54994 | ARHGAP18 | 93663 | 9 | 7 | 37 | |
| GSE60625 | ARHGAP18 | 93663 | 0 | 1 | 10 | |
| GSE74703 | ARHGAP18 | 93663 | 4 | 0 | 32 | |
| GSE74704 | ARHGAP18 | 93663 | 0 | 1 | 19 | |
| TCGA | ARHGAP18 | 93663 | 11 | 18 | 67 |
Total number of gains: 45; Total number of losses: 52; Total Number of normals: 391.
Somatic mutations of ARHGAP18:
Generating mutation plots.
Highly correlated genes for ARHGAP18:
Showing top 20/641 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGAP18 | SNX5 | 0.827121 | 3 | 0 | 3 |
| ARHGAP18 | KHDRBS1 | 0.797082 | 3 | 0 | 3 |
| ARHGAP18 | DROSHA | 0.783035 | 3 | 0 | 3 |
| ARHGAP18 | B3GALT6 | 0.76493 | 3 | 0 | 3 |
| ARHGAP18 | WDR81 | 0.760621 | 3 | 0 | 3 |
| ARHGAP18 | CPSF6 | 0.759702 | 3 | 0 | 3 |
| ARHGAP18 | GPR141 | 0.752485 | 3 | 0 | 3 |
| ARHGAP18 | IGSF6 | 0.746343 | 5 | 0 | 5 |
| ARHGAP18 | DNMT1 | 0.744935 | 3 | 0 | 3 |
| ARHGAP18 | STK3 | 0.742968 | 3 | 0 | 3 |
| ARHGAP18 | EFTUD2 | 0.741234 | 3 | 0 | 3 |
| ARHGAP18 | PILRA | 0.740976 | 3 | 0 | 3 |
| ARHGAP18 | USP22 | 0.740068 | 3 | 0 | 3 |
| ARHGAP18 | PEX2 | 0.739954 | 3 | 0 | 3 |
| ARHGAP18 | AURKA | 0.736682 | 3 | 0 | 3 |
| ARHGAP18 | DNAJC2 | 0.736387 | 3 | 0 | 3 |
| ARHGAP18 | GRB2 | 0.734873 | 3 | 0 | 3 |
| ARHGAP18 | RRAS2 | 0.734583 | 3 | 0 | 3 |
| ARHGAP18 | PMPCB | 0.734103 | 3 | 0 | 3 |
| ARHGAP18 | HDAC1 | 0.731131 | 3 | 0 | 3 |
For details and further investigation, click here
