MAPK9

 

Full name: mitogen-activated protein kinase 9 Alias Symbol: JNK2|p54a|SAPK
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 5601 HGNC ID: HGNC:6886 Ensembl Gene: ENSG00000050748 OMIM ID: 602896
Drug and gene relationship at DGIdb

 

MAPK9 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of MAPK9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK9 5601 203218_at 0.0940 0.8337
GSE20347 MAPK9 5601 203218_at -0.1217 0.6645
GSE23400 MAPK9 5601 210570_x_at -0.0746 0.1278
GSE26886 MAPK9 5601 203218_at 0.4803 0.0220
GSE29001 MAPK9 5601 203218_at -0.0079 0.9850
GSE38129 MAPK9 5601 203218_at 0.0275 0.8907
GSE45670 MAPK9 5601 203218_at 0.0167 0.9375
GSE53622 MAPK9 5601 52441 -0.0028 0.9714
GSE53624 MAPK9 5601 52441 0.1735 0.0059
GSE63941 MAPK9 5601 203218_at 0.0579 0.9142
GSE77861 MAPK9 5601 225781_at 0.0727 0.7154
GSE97050 MAPK9 5601 A_23_P167692 0.0392 0.9162
SRP007169 MAPK9 5601 RNAseq -0.7090 0.0899
SRP008496 MAPK9 5601 RNAseq -0.5832 0.0421
SRP064894 MAPK9 5601 RNAseq -0.0767 0.4737
SRP133303 MAPK9 5601 RNAseq 0.2662 0.0889
SRP159526 MAPK9 5601 RNAseq 0.0915 0.8348
SRP193095 MAPK9 5601 RNAseq -0.0523 0.6579
SRP219564 MAPK9 5601 RNAseq 0.1001 0.7816
TCGA MAPK9 5601 RNAseq -0.1877 0.0001

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MAPK9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK9 5601 2 12 16
GSE20123 MAPK9 5601 2 12 16
GSE43470 MAPK9 5601 1 11 31
GSE46452 MAPK9 5601 0 27 32
GSE47630 MAPK9 5601 1 20 19
GSE54993 MAPK9 5601 10 2 58
GSE54994 MAPK9 5601 3 17 33
GSE60625 MAPK9 5601 1 0 10
GSE74703 MAPK9 5601 1 7 28
GSE74704 MAPK9 5601 1 6 13
TCGA MAPK9 5601 12 34 50

Total number of gains: 34; Total number of losses: 148; Total Number of normals: 306.  

 

Somatic mutations of MAPK9:

 

Generating mutation plots.

 

Highly correlated genes for MAPK9:

 

Showing top 20/341 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK9SMARCA50.788799303
MAPK9HES40.769639303
MAPK9AIMP10.765012303
MAPK9SCAMP10.745965303
MAPK9APIP0.744732303
MAPK9ZNF6830.744084303
MAPK9BHLHE410.736571303
MAPK9ADAM90.732268303
MAPK9BICD20.731872303
MAPK9DEGS10.729221303
MAPK9MYOF0.722161303
MAPK9ZDHHC170.71916303
MAPK9NDUFS10.71817303
MAPK9DR10.716579303
MAPK9GAS2L10.714513303
MAPK9HDAC10.712155303
MAPK9SLC16A20.702418303
MAPK9MNAT10.700551303
MAPK9TBC1D280.700278303
MAPK9SLC24A10.700195303

For details and further investigation, click here