| Full name: SMAD family member 1 | Alias Symbol: MADR1|JV4-1 | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 4086 | HGNC ID: HGNC:6767 | Ensembl Gene: ENSG00000170365 | OMIM ID: 601595 |
| Drug and gene relationship at DGIdb | |||
SMAD1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of SMAD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMAD1 | 4086 | 227798_at | 0.4918 | 0.1928 | |
| GSE20347 | SMAD1 | 4086 | 210993_s_at | 0.1841 | 0.6622 | |
| GSE23400 | SMAD1 | 4086 | 210993_s_at | 0.4324 | 0.0011 | |
| GSE26886 | SMAD1 | 4086 | 227798_at | 0.3079 | 0.3554 | |
| GSE29001 | SMAD1 | 4086 | 210993_s_at | 0.2235 | 0.6236 | |
| GSE38129 | SMAD1 | 4086 | 210993_s_at | 0.3780 | 0.1355 | |
| GSE45670 | SMAD1 | 4086 | 227798_at | 0.3826 | 0.0212 | |
| GSE63941 | SMAD1 | 4086 | 210993_s_at | 0.7442 | 0.2629 | |
| GSE77861 | SMAD1 | 4086 | 210993_s_at | 0.7646 | 0.0341 | |
| GSE97050 | SMAD1 | 4086 | A_24_P71938 | 0.1959 | 0.5467 | |
| SRP007169 | SMAD1 | 4086 | RNAseq | 0.4357 | 0.3056 | |
| SRP008496 | SMAD1 | 4086 | RNAseq | 0.6939 | 0.0200 | |
| SRP064894 | SMAD1 | 4086 | RNAseq | 0.5022 | 0.0068 | |
| SRP133303 | SMAD1 | 4086 | RNAseq | 0.8221 | 0.0000 | |
| SRP159526 | SMAD1 | 4086 | RNAseq | 0.5347 | 0.1487 | |
| SRP193095 | SMAD1 | 4086 | RNAseq | 0.5629 | 0.0009 | |
| SRP219564 | SMAD1 | 4086 | RNAseq | 0.1544 | 0.6806 | |
| TCGA | SMAD1 | 4086 | RNAseq | 0.2255 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMAD1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SMAD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMAD1 | 4086 | 0 | 12 | 18 | |
| GSE20123 | SMAD1 | 4086 | 0 | 12 | 18 | |
| GSE43470 | SMAD1 | 4086 | 0 | 13 | 30 | |
| GSE46452 | SMAD1 | 4086 | 1 | 36 | 22 | |
| GSE47630 | SMAD1 | 4086 | 0 | 22 | 18 | |
| GSE54993 | SMAD1 | 4086 | 10 | 0 | 60 | |
| GSE54994 | SMAD1 | 4086 | 2 | 11 | 40 | |
| GSE60625 | SMAD1 | 4086 | 0 | 1 | 10 | |
| GSE74703 | SMAD1 | 4086 | 0 | 11 | 25 | |
| GSE74704 | SMAD1 | 4086 | 0 | 7 | 13 | |
| TCGA | SMAD1 | 4086 | 12 | 32 | 52 |
Total number of gains: 25; Total number of losses: 157; Total Number of normals: 306.
Somatic mutations of SMAD1:
Generating mutation plots.
Highly correlated genes for SMAD1:
Showing top 20/615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMAD1 | ADRM1 | 0.821543 | 3 | 0 | 3 |
| SMAD1 | ZNF551 | 0.813539 | 3 | 0 | 3 |
| SMAD1 | TMEM69 | 0.792369 | 3 | 0 | 3 |
| SMAD1 | RNF217 | 0.785942 | 3 | 0 | 3 |
| SMAD1 | KRI1 | 0.779513 | 3 | 0 | 3 |
| SMAD1 | WDR5 | 0.778092 | 3 | 0 | 3 |
| SMAD1 | GMEB2 | 0.77779 | 3 | 0 | 3 |
| SMAD1 | ELOF1 | 0.773984 | 3 | 0 | 3 |
| SMAD1 | DDX55 | 0.770479 | 3 | 0 | 3 |
| SMAD1 | PPHLN1 | 0.766124 | 3 | 0 | 3 |
| SMAD1 | TRUB2 | 0.764292 | 3 | 0 | 3 |
| SMAD1 | EEF1D | 0.764183 | 3 | 0 | 3 |
| SMAD1 | USP22 | 0.76202 | 3 | 0 | 3 |
| SMAD1 | NACC1 | 0.761899 | 3 | 0 | 3 |
| SMAD1 | SDHAF2 | 0.75902 | 3 | 0 | 3 |
| SMAD1 | RBM26 | 0.753639 | 3 | 0 | 3 |
| SMAD1 | SND1 | 0.752275 | 3 | 0 | 3 |
| SMAD1 | MAGEF1 | 0.751317 | 3 | 0 | 3 |
| SMAD1 | RFWD3 | 0.748704 | 3 | 0 | 3 |
| SMAD1 | ARHGAP19 | 0.747975 | 3 | 0 | 3 |
For details and further investigation, click here
