| Full name: HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 | Alias Symbol: KIAA1667|LE|BLOC3S2 | ||
| Type: protein-coding gene | Cytoband: 22q12.1 | ||
| Entrez ID: 89781 | HGNC ID: HGNC:15844 | Ensembl Gene: ENSG00000100099 | OMIM ID: 606682 |
| Drug and gene relationship at DGIdb | |||
Expression of HPS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPS4 | 89781 | 218402_s_at | 0.2559 | 0.2735 | |
| GSE20347 | HPS4 | 89781 | 218402_s_at | -0.0472 | 0.7157 | |
| GSE23400 | HPS4 | 89781 | 218402_s_at | 0.1999 | 0.0007 | |
| GSE26886 | HPS4 | 89781 | 218402_s_at | -0.1487 | 0.4725 | |
| GSE29001 | HPS4 | 89781 | 54037_at | 0.5446 | 0.2296 | |
| GSE38129 | HPS4 | 89781 | 218402_s_at | 0.2395 | 0.0510 | |
| GSE45670 | HPS4 | 89781 | 54037_at | 0.3646 | 0.0041 | |
| GSE53622 | HPS4 | 89781 | 105976 | 0.2672 | 0.0013 | |
| GSE53624 | HPS4 | 89781 | 105976 | 0.3325 | 0.0000 | |
| GSE63941 | HPS4 | 89781 | 218402_s_at | -0.1410 | 0.6177 | |
| GSE77861 | HPS4 | 89781 | 218402_s_at | 0.2649 | 0.1968 | |
| GSE97050 | HPS4 | 89781 | A_33_P3290082 | 0.2044 | 0.5743 | |
| SRP007169 | HPS4 | 89781 | RNAseq | -0.1221 | 0.7038 | |
| SRP008496 | HPS4 | 89781 | RNAseq | -0.2344 | 0.2142 | |
| SRP064894 | HPS4 | 89781 | RNAseq | 0.4534 | 0.0273 | |
| SRP133303 | HPS4 | 89781 | RNAseq | 0.1288 | 0.4487 | |
| SRP159526 | HPS4 | 89781 | RNAseq | 0.2492 | 0.2447 | |
| SRP193095 | HPS4 | 89781 | RNAseq | 0.2706 | 0.0112 | |
| SRP219564 | HPS4 | 89781 | RNAseq | 0.4102 | 0.2867 | |
| TCGA | HPS4 | 89781 | RNAseq | 0.0537 | 0.2760 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HPS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPS4 | 89781 | 3 | 5 | 22 | |
| GSE20123 | HPS4 | 89781 | 3 | 4 | 23 | |
| GSE43470 | HPS4 | 89781 | 4 | 6 | 33 | |
| GSE46452 | HPS4 | 89781 | 31 | 1 | 27 | |
| GSE47630 | HPS4 | 89781 | 8 | 5 | 27 | |
| GSE54993 | HPS4 | 89781 | 3 | 6 | 61 | |
| GSE54994 | HPS4 | 89781 | 11 | 8 | 34 | |
| GSE60625 | HPS4 | 89781 | 5 | 0 | 6 | |
| GSE74703 | HPS4 | 89781 | 3 | 5 | 28 | |
| GSE74704 | HPS4 | 89781 | 0 | 1 | 19 | |
| TCGA | HPS4 | 89781 | 26 | 14 | 56 |
Total number of gains: 97; Total number of losses: 55; Total Number of normals: 336.
Somatic mutations of HPS4:
Generating mutation plots.
Highly correlated genes for HPS4:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPS4 | TBC1D16 | 0.793081 | 3 | 0 | 3 |
| HPS4 | EEF1D | 0.788648 | 3 | 0 | 3 |
| HPS4 | ADAM15 | 0.741335 | 3 | 0 | 3 |
| HPS4 | HDAC1 | 0.731257 | 4 | 0 | 3 |
| HPS4 | SPIRE2 | 0.724421 | 3 | 0 | 3 |
| HPS4 | GIT1 | 0.721689 | 3 | 0 | 3 |
| HPS4 | OLA1 | 0.71736 | 3 | 0 | 3 |
| HPS4 | SNX30 | 0.716906 | 3 | 0 | 3 |
| HPS4 | TRIM62 | 0.714813 | 3 | 0 | 3 |
| HPS4 | TTC30B | 0.711411 | 3 | 0 | 3 |
| HPS4 | NCEH1 | 0.706247 | 3 | 0 | 3 |
| HPS4 | RTN4R | 0.70561 | 3 | 0 | 3 |
| HPS4 | CPSF3 | 0.705174 | 4 | 0 | 4 |
| HPS4 | SEMA4C | 0.700932 | 3 | 0 | 3 |
| HPS4 | SP140L | 0.699178 | 4 | 0 | 3 |
| HPS4 | ZMYND19 | 0.698141 | 3 | 0 | 3 |
| HPS4 | LRIF1 | 0.696251 | 4 | 0 | 3 |
| HPS4 | UBR4 | 0.695741 | 4 | 0 | 4 |
| HPS4 | KDM2A | 0.690314 | 4 | 0 | 4 |
| HPS4 | MDM2 | 0.69027 | 3 | 0 | 3 |
For details and further investigation, click here
