| Full name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Alias Symbol: p532|p619 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 8925 | HGNC ID: HGNC:4867 | Ensembl Gene: ENSG00000103657 | OMIM ID: 605109 |
| Drug and gene relationship at DGIdb | |||
Expression of HERC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HERC1 | 8925 | 218306_s_at | -0.1594 | 0.5797 | |
| GSE20347 | HERC1 | 8925 | 218306_s_at | -0.1396 | 0.3514 | |
| GSE23400 | HERC1 | 8925 | 218306_s_at | -0.1415 | 0.0699 | |
| GSE26886 | HERC1 | 8925 | 218306_s_at | 0.0032 | 0.9911 | |
| GSE29001 | HERC1 | 8925 | 218306_s_at | -0.2121 | 0.1997 | |
| GSE38129 | HERC1 | 8925 | 218306_s_at | -0.3143 | 0.0112 | |
| GSE45670 | HERC1 | 8925 | 218306_s_at | -0.3818 | 0.0080 | |
| GSE53622 | HERC1 | 8925 | 9162 | -0.3942 | 0.0000 | |
| GSE53624 | HERC1 | 8925 | 14545 | -0.3366 | 0.0000 | |
| GSE63941 | HERC1 | 8925 | 218306_s_at | -0.7300 | 0.0174 | |
| GSE77861 | HERC1 | 8925 | 218306_s_at | -0.2265 | 0.5693 | |
| GSE97050 | HERC1 | 8925 | A_23_P257503 | -0.3942 | 0.2232 | |
| SRP007169 | HERC1 | 8925 | RNAseq | 0.7398 | 0.0879 | |
| SRP008496 | HERC1 | 8925 | RNAseq | 0.5174 | 0.0615 | |
| SRP064894 | HERC1 | 8925 | RNAseq | -0.2491 | 0.3284 | |
| SRP133303 | HERC1 | 8925 | RNAseq | -0.1888 | 0.0572 | |
| SRP159526 | HERC1 | 8925 | RNAseq | -0.5757 | 0.0289 | |
| SRP193095 | HERC1 | 8925 | RNAseq | -0.0877 | 0.3769 | |
| SRP219564 | HERC1 | 8925 | RNAseq | -0.1636 | 0.6553 | |
| TCGA | HERC1 | 8925 | RNAseq | -0.2812 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HERC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HERC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HERC1 | 8925 | 8 | 2 | 20 | |
| GSE20123 | HERC1 | 8925 | 8 | 2 | 20 | |
| GSE43470 | HERC1 | 8925 | 4 | 6 | 33 | |
| GSE46452 | HERC1 | 8925 | 3 | 7 | 49 | |
| GSE47630 | HERC1 | 8925 | 8 | 10 | 22 | |
| GSE54993 | HERC1 | 8925 | 5 | 6 | 59 | |
| GSE54994 | HERC1 | 8925 | 6 | 8 | 39 | |
| GSE60625 | HERC1 | 8925 | 4 | 0 | 7 | |
| GSE74703 | HERC1 | 8925 | 4 | 3 | 29 | |
| GSE74704 | HERC1 | 8925 | 4 | 2 | 14 | |
| TCGA | HERC1 | 8925 | 10 | 16 | 70 |
Total number of gains: 64; Total number of losses: 62; Total Number of normals: 362.
Somatic mutations of HERC1:
Generating mutation plots.
Highly correlated genes for HERC1:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HERC1 | LIMD2 | 0.784481 | 3 | 0 | 3 |
| HERC1 | RHOJ | 0.779303 | 3 | 0 | 3 |
| HERC1 | POLK | 0.737889 | 3 | 0 | 3 |
| HERC1 | C11orf96 | 0.737467 | 3 | 0 | 3 |
| HERC1 | AGBL5 | 0.733776 | 3 | 0 | 3 |
| HERC1 | WTIP | 0.728924 | 3 | 0 | 3 |
| HERC1 | CYYR1 | 0.726394 | 4 | 0 | 3 |
| HERC1 | GSTT1 | 0.725779 | 3 | 0 | 3 |
| HERC1 | CHADL | 0.718352 | 3 | 0 | 3 |
| HERC1 | LCOR | 0.718089 | 3 | 0 | 3 |
| HERC1 | MSRB3 | 0.71411 | 4 | 0 | 4 |
| HERC1 | BVES | 0.710875 | 4 | 0 | 4 |
| HERC1 | FNIP2 | 0.710688 | 4 | 0 | 4 |
| HERC1 | BMP4 | 0.708636 | 3 | 0 | 3 |
| HERC1 | EBF3 | 0.699329 | 4 | 0 | 3 |
| HERC1 | UBXN10 | 0.699247 | 3 | 0 | 3 |
| HERC1 | ACSS3 | 0.698012 | 4 | 0 | 4 |
| HERC1 | RUFY1 | 0.697678 | 4 | 0 | 3 |
| HERC1 | FAM13C | 0.695279 | 4 | 0 | 4 |
| HERC1 | CLEC3B | 0.694522 | 3 | 0 | 3 |
For details and further investigation, click here
