| Full name: bone morphogenetic protein 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q22.2 | ||
| Entrez ID: 652 | HGNC ID: HGNC:1071 | Ensembl Gene: ENSG00000125378 | OMIM ID: 112262 |
| Drug and gene relationship at DGIdb | |||
BMP4 involved pathways:
Expression of BMP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP4 | 652 | 211518_s_at | -0.8955 | 0.1563 | |
| GSE20347 | BMP4 | 652 | 211518_s_at | 0.0095 | 0.9448 | |
| GSE23400 | BMP4 | 652 | 211518_s_at | -0.3225 | 0.0000 | |
| GSE26886 | BMP4 | 652 | 211518_s_at | 0.1922 | 0.4915 | |
| GSE29001 | BMP4 | 652 | 211518_s_at | -0.1682 | 0.3877 | |
| GSE38129 | BMP4 | 652 | 211518_s_at | -0.3701 | 0.1042 | |
| GSE45670 | BMP4 | 652 | 211518_s_at | -0.3538 | 0.1657 | |
| GSE53622 | BMP4 | 652 | 123910 | -0.4459 | 0.0079 | |
| GSE53624 | BMP4 | 652 | 123910 | 0.0291 | 0.8728 | |
| GSE63941 | BMP4 | 652 | 211518_s_at | -2.8737 | 0.0000 | |
| GSE77861 | BMP4 | 652 | 211518_s_at | 0.7041 | 0.2955 | |
| GSE97050 | BMP4 | 652 | A_23_P54144 | -0.3429 | 0.5222 | |
| SRP007169 | BMP4 | 652 | RNAseq | -0.3872 | 0.6314 | |
| SRP064894 | BMP4 | 652 | RNAseq | -1.0420 | 0.0005 | |
| SRP133303 | BMP4 | 652 | RNAseq | -0.6094 | 0.0446 | |
| SRP159526 | BMP4 | 652 | RNAseq | -0.2430 | 0.5771 | |
| SRP193095 | BMP4 | 652 | RNAseq | 0.2659 | 0.4736 | |
| SRP219564 | BMP4 | 652 | RNAseq | -0.4777 | 0.3356 | |
| TCGA | BMP4 | 652 | RNAseq | -0.5047 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BMP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP4 | 652 | 8 | 3 | 19 | |
| GSE20123 | BMP4 | 652 | 8 | 3 | 19 | |
| GSE43470 | BMP4 | 652 | 9 | 1 | 33 | |
| GSE46452 | BMP4 | 652 | 16 | 3 | 40 | |
| GSE47630 | BMP4 | 652 | 11 | 10 | 19 | |
| GSE54993 | BMP4 | 652 | 3 | 8 | 59 | |
| GSE54994 | BMP4 | 652 | 19 | 4 | 30 | |
| GSE60625 | BMP4 | 652 | 0 | 2 | 9 | |
| GSE74703 | BMP4 | 652 | 8 | 1 | 27 | |
| GSE74704 | BMP4 | 652 | 3 | 2 | 15 | |
| TCGA | BMP4 | 652 | 33 | 13 | 50 |
Total number of gains: 118; Total number of losses: 50; Total Number of normals: 320.
Somatic mutations of BMP4:
Generating mutation plots.
Highly correlated genes for BMP4:
Showing top 20/689 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP4 | TMEM178A | 0.849061 | 3 | 0 | 3 |
| BMP4 | MGAT5 | 0.749416 | 3 | 0 | 3 |
| BMP4 | ZNF382 | 0.739105 | 3 | 0 | 3 |
| BMP4 | PNMA2 | 0.737492 | 3 | 0 | 3 |
| BMP4 | TIMP3 | 0.733348 | 4 | 0 | 4 |
| BMP4 | INMT | 0.732942 | 4 | 0 | 4 |
| BMP4 | CYP4V2 | 0.729675 | 3 | 0 | 3 |
| BMP4 | ST6GALNAC6 | 0.724414 | 3 | 0 | 3 |
| BMP4 | STARD13 | 0.722958 | 4 | 0 | 4 |
| BMP4 | PTPN21 | 0.713969 | 3 | 0 | 3 |
| BMP4 | FOXN3 | 0.713852 | 4 | 0 | 3 |
| BMP4 | JAZF1 | 0.710167 | 3 | 0 | 3 |
| BMP4 | HERC1 | 0.708636 | 3 | 0 | 3 |
| BMP4 | IL11RA | 0.708062 | 4 | 0 | 4 |
| BMP4 | MGARP | 0.70581 | 3 | 0 | 3 |
| BMP4 | MAN2B2 | 0.70144 | 3 | 0 | 3 |
| BMP4 | CHL1 | 0.696141 | 4 | 0 | 4 |
| BMP4 | TNFAIP8L3 | 0.695603 | 3 | 0 | 3 |
| BMP4 | HMCN1 | 0.690603 | 7 | 0 | 5 |
| BMP4 | SLC16A4 | 0.68943 | 7 | 0 | 6 |
For details and further investigation, click here
