| Full name: HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Alias Symbol: jdf2|p528|D15F37S1 | ||
| Type: protein-coding gene | Cytoband: 15q13.1 | ||
| Entrez ID: 8924 | HGNC ID: HGNC:4868 | Ensembl Gene: ENSG00000128731 | OMIM ID: 605837 |
| Drug and gene relationship at DGIdb | |||
Expression of HERC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HERC2 | 8924 | 217902_s_at | 0.1451 | 0.8005 | |
| GSE20347 | HERC2 | 8924 | 217902_s_at | -0.0827 | 0.6711 | |
| GSE23400 | HERC2 | 8924 | 217902_s_at | 0.1993 | 0.0374 | |
| GSE26886 | HERC2 | 8924 | 217902_s_at | 1.0899 | 0.0000 | |
| GSE29001 | HERC2 | 8924 | 217902_s_at | 0.2594 | 0.3409 | |
| GSE38129 | HERC2 | 8924 | 217902_s_at | -0.0881 | 0.5160 | |
| GSE45670 | HERC2 | 8924 | 217902_s_at | -0.1156 | 0.4855 | |
| GSE53622 | HERC2 | 8924 | 14685 | 0.0731 | 0.3815 | |
| GSE53624 | HERC2 | 8924 | 14685 | 0.1452 | 0.0332 | |
| GSE63941 | HERC2 | 8924 | 217902_s_at | -1.0330 | 0.0086 | |
| GSE77861 | HERC2 | 8924 | 217902_s_at | 0.2113 | 0.4400 | |
| GSE97050 | HERC2 | A_21_P0011349 | -0.4095 | 0.1969 | ||
| SRP007169 | HERC2 | 8924 | RNAseq | 1.2471 | 0.0004 | |
| SRP008496 | HERC2 | 8924 | RNAseq | 1.0975 | 0.0004 | |
| SRP064894 | HERC2 | 8924 | RNAseq | 0.2129 | 0.4099 | |
| SRP133303 | HERC2 | 8924 | RNAseq | -0.0700 | 0.5752 | |
| SRP159526 | HERC2 | 8924 | RNAseq | -0.0903 | 0.5452 | |
| SRP193095 | HERC2 | 8924 | RNAseq | 0.3463 | 0.0052 | |
| SRP219564 | HERC2 | 8924 | RNAseq | -0.2921 | 0.3285 | |
| TCGA | HERC2 | 8924 | RNAseq | -0.0943 | 0.0264 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by HERC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HERC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HERC2 | 8924 | 3 | 7 | 20 | |
| GSE20123 | HERC2 | 8924 | 3 | 7 | 20 | |
| GSE43470 | HERC2 | 8924 | 4 | 5 | 34 | |
| GSE46452 | HERC2 | 8924 | 3 | 7 | 49 | |
| GSE47630 | HERC2 | 8924 | 8 | 11 | 21 | |
| GSE54993 | HERC2 | 8924 | 4 | 6 | 60 | |
| GSE54994 | HERC2 | 8924 | 7 | 6 | 40 | |
| GSE60625 | HERC2 | 8924 | 4 | 0 | 7 | |
| GSE74703 | HERC2 | 8924 | 4 | 3 | 29 | |
| GSE74704 | HERC2 | 8924 | 2 | 5 | 13 | |
| TCGA | HERC2 | 8924 | 16 | 17 | 63 |
Total number of gains: 58; Total number of losses: 74; Total Number of normals: 356.
Somatic mutations of HERC2:
Generating mutation plots.
Highly correlated genes for HERC2:
Showing top 20/455 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HERC2 | LSM10 | 0.809959 | 3 | 0 | 3 |
| HERC2 | CNN1 | 0.77513 | 3 | 0 | 3 |
| HERC2 | DDX20 | 0.772011 | 3 | 0 | 3 |
| HERC2 | RILPL2 | 0.761845 | 3 | 0 | 3 |
| HERC2 | FAM171B | 0.757348 | 3 | 0 | 3 |
| HERC2 | SH3RF3 | 0.757094 | 3 | 0 | 3 |
| HERC2 | COG2 | 0.757054 | 3 | 0 | 3 |
| HERC2 | HABP4 | 0.753772 | 3 | 0 | 3 |
| HERC2 | C11orf96 | 0.75294 | 3 | 0 | 3 |
| HERC2 | C11orf49 | 0.746983 | 3 | 0 | 3 |
| HERC2 | CTSF | 0.746221 | 3 | 0 | 3 |
| HERC2 | FOXF1 | 0.742071 | 3 | 0 | 3 |
| HERC2 | RNF26 | 0.737478 | 3 | 0 | 3 |
| HERC2 | CDK5RAP2 | 0.734364 | 3 | 0 | 3 |
| HERC2 | CASC4 | 0.729734 | 4 | 0 | 4 |
| HERC2 | CEP68 | 0.727592 | 3 | 0 | 3 |
| HERC2 | PPP1R10 | 0.727121 | 3 | 0 | 3 |
| HERC2 | GMPR | 0.726477 | 3 | 0 | 3 |
| HERC2 | USP13 | 0.72441 | 3 | 0 | 3 |
| HERC2 | DOCK11 | 0.724366 | 3 | 0 | 3 |
For details and further investigation, click here
