| Full name: cancer susceptibility 4 | Alias Symbol: H63|DKFZp459F1927 | ||
| Type: protein-coding gene | Cytoband: 15q15.3 | ||
| Entrez ID: 113201 | HGNC ID: HGNC:24892 | Ensembl Gene: ENSG00000166734 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CASC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASC4 | 113201 | 224619_at | -0.2473 | 0.6015 | |
| GSE26886 | CASC4 | 113201 | 224619_at | 0.8372 | 0.0003 | |
| GSE45670 | CASC4 | 113201 | 224619_at | -0.3810 | 0.0211 | |
| GSE53622 | CASC4 | 113201 | 3595 | 0.1548 | 0.0846 | |
| GSE53624 | CASC4 | 113201 | 3595 | 0.1560 | 0.0160 | |
| GSE63941 | CASC4 | 113201 | 224619_at | -1.4394 | 0.0014 | |
| GSE77861 | CASC4 | 113201 | 224619_at | 0.5780 | 0.0377 | |
| GSE97050 | CASC4 | 113201 | A_24_P398940 | -0.1041 | 0.6537 | |
| SRP007169 | CASC4 | 113201 | RNAseq | 1.2358 | 0.0010 | |
| SRP008496 | CASC4 | 113201 | RNAseq | 1.3097 | 0.0000 | |
| SRP064894 | CASC4 | 113201 | RNAseq | 0.3280 | 0.1869 | |
| SRP133303 | CASC4 | 113201 | RNAseq | 0.4372 | 0.0032 | |
| SRP159526 | CASC4 | 113201 | RNAseq | 0.4259 | 0.1918 | |
| SRP193095 | CASC4 | 113201 | RNAseq | 0.2881 | 0.1284 | |
| SRP219564 | CASC4 | 113201 | RNAseq | 0.2123 | 0.6265 | |
| TCGA | CASC4 | 113201 | RNAseq | -0.1600 | 0.0004 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by CASC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASC4 | 113201 | 3 | 4 | 23 | |
| GSE20123 | CASC4 | 113201 | 3 | 5 | 22 | |
| GSE43470 | CASC4 | 113201 | 3 | 4 | 36 | |
| GSE46452 | CASC4 | 113201 | 3 | 7 | 49 | |
| GSE47630 | CASC4 | 113201 | 8 | 10 | 22 | |
| GSE54993 | CASC4 | 113201 | 4 | 6 | 60 | |
| GSE54994 | CASC4 | 113201 | 5 | 7 | 41 | |
| GSE60625 | CASC4 | 113201 | 4 | 0 | 7 | |
| GSE74703 | CASC4 | 113201 | 3 | 3 | 30 | |
| GSE74704 | CASC4 | 113201 | 2 | 2 | 16 | |
| TCGA | CASC4 | 113201 | 12 | 17 | 67 |
Total number of gains: 50; Total number of losses: 65; Total Number of normals: 373.
Somatic mutations of CASC4:
Generating mutation plots.
Highly correlated genes for CASC4:
Showing top 20/1075 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASC4 | NOL9 | 0.864007 | 3 | 0 | 3 |
| CASC4 | MAK16 | 0.813036 | 3 | 0 | 3 |
| CASC4 | TRRAP | 0.80262 | 3 | 0 | 3 |
| CASC4 | SMCR8 | 0.800981 | 3 | 0 | 3 |
| CASC4 | SLC6A6 | 0.797823 | 3 | 0 | 3 |
| CASC4 | DPF2 | 0.785988 | 3 | 0 | 3 |
| CASC4 | SHC1 | 0.78588 | 3 | 0 | 3 |
| CASC4 | ADCY3 | 0.772099 | 3 | 0 | 3 |
| CASC4 | GNS | 0.762432 | 4 | 0 | 4 |
| CASC4 | JAK1 | 0.759792 | 3 | 0 | 3 |
| CASC4 | KIAA0895L | 0.756263 | 3 | 0 | 3 |
| CASC4 | CUX1 | 0.755517 | 3 | 0 | 3 |
| CASC4 | PTPN14 | 0.755445 | 3 | 0 | 3 |
| CASC4 | BMPR2 | 0.754924 | 4 | 0 | 4 |
| CASC4 | RNF19A | 0.749941 | 3 | 0 | 3 |
| CASC4 | SHPRH | 0.748554 | 3 | 0 | 3 |
| CASC4 | SNF8 | 0.747816 | 3 | 0 | 3 |
| CASC4 | CAV2 | 0.74581 | 3 | 0 | 3 |
| CASC4 | COL4A5 | 0.741351 | 3 | 0 | 3 |
| CASC4 | VMA21 | 0.738567 | 3 | 0 | 3 |
For details and further investigation, click here
