| Full name: protein phosphatase 1 regulatory subunit 10 | Alias Symbol: PNUTS|FB19|CAT53|p99 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 5514 | HGNC ID: HGNC:9284 | Ensembl Gene: ENSG00000204569 | OMIM ID: 603771 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP1R10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R10 | 5514 | 201703_s_at | 0.5765 | 0.2770 | |
| GSE20347 | PPP1R10 | 5514 | 201703_s_at | 0.1767 | 0.1748 | |
| GSE23400 | PPP1R10 | 5514 | 201703_s_at | 0.2922 | 0.0000 | |
| GSE26886 | PPP1R10 | 5514 | 201703_s_at | -0.3735 | 0.0930 | |
| GSE29001 | PPP1R10 | 5514 | 201702_s_at | 0.0801 | 0.7539 | |
| GSE38129 | PPP1R10 | 5514 | 201703_s_at | 0.1175 | 0.3135 | |
| GSE45670 | PPP1R10 | 5514 | 201703_s_at | 0.2629 | 0.0227 | |
| GSE53622 | PPP1R10 | 5514 | 28035 | -0.1211 | 0.0711 | |
| GSE53624 | PPP1R10 | 5514 | 97548 | 0.2438 | 0.0083 | |
| GSE63941 | PPP1R10 | 5514 | 201703_s_at | 0.4569 | 0.1466 | |
| GSE77861 | PPP1R10 | 5514 | 201703_s_at | 0.4140 | 0.0979 | |
| GSE97050 | PPP1R10 | 5514 | A_23_P156667 | -0.2159 | 0.2613 | |
| SRP007169 | PPP1R10 | 5514 | RNAseq | 0.7264 | 0.0400 | |
| SRP008496 | PPP1R10 | 5514 | RNAseq | 0.3492 | 0.1060 | |
| SRP064894 | PPP1R10 | 5514 | RNAseq | 0.2602 | 0.0334 | |
| SRP133303 | PPP1R10 | 5514 | RNAseq | 0.0923 | 0.6028 | |
| SRP159526 | PPP1R10 | 5514 | RNAseq | 0.2912 | 0.1255 | |
| SRP193095 | PPP1R10 | 5514 | RNAseq | 0.0160 | 0.8538 | |
| SRP219564 | PPP1R10 | 5514 | RNAseq | -0.2536 | 0.5528 | |
| TCGA | PPP1R10 | 5514 | RNAseq | -0.0709 | 0.1101 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R10 | 5514 | 5 | 1 | 24 | |
| GSE20123 | PPP1R10 | 5514 | 5 | 1 | 24 | |
| GSE43470 | PPP1R10 | 5514 | 5 | 1 | 37 | |
| GSE46452 | PPP1R10 | 5514 | 1 | 10 | 48 | |
| GSE47630 | PPP1R10 | 5514 | 7 | 3 | 30 | |
| GSE54993 | PPP1R10 | 5514 | 2 | 1 | 67 | |
| GSE54994 | PPP1R10 | 5514 | 11 | 4 | 38 | |
| GSE60625 | PPP1R10 | 5514 | 0 | 1 | 10 | |
| GSE74703 | PPP1R10 | 5514 | 5 | 0 | 31 | |
| GSE74704 | PPP1R10 | 5514 | 2 | 0 | 18 | |
| TCGA | PPP1R10 | 5514 | 18 | 16 | 62 |
Total number of gains: 61; Total number of losses: 38; Total Number of normals: 389.
Somatic mutations of PPP1R10:
Generating mutation plots.
Highly correlated genes for PPP1R10:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R10 | ZNF641 | 0.76273 | 3 | 0 | 3 |
| PPP1R10 | MRPS26 | 0.757548 | 3 | 0 | 3 |
| PPP1R10 | IWS1 | 0.754788 | 3 | 0 | 3 |
| PPP1R10 | NOM1 | 0.740558 | 3 | 0 | 3 |
| PPP1R10 | NDUFS2 | 0.737165 | 3 | 0 | 3 |
| PPP1R10 | AEBP2 | 0.735814 | 3 | 0 | 3 |
| PPP1R10 | PSPC1 | 0.735116 | 3 | 0 | 3 |
| PPP1R10 | TET1 | 0.734083 | 3 | 0 | 3 |
| PPP1R10 | DNAH14 | 0.732867 | 3 | 0 | 3 |
| PPP1R10 | TNRC18 | 0.73233 | 3 | 0 | 3 |
| PPP1R10 | KHNYN | 0.729035 | 3 | 0 | 3 |
| PPP1R10 | HERC2 | 0.727121 | 3 | 0 | 3 |
| PPP1R10 | KDM5C | 0.726346 | 3 | 0 | 3 |
| PPP1R10 | ARAP1 | 0.716386 | 3 | 0 | 3 |
| PPP1R10 | SPSB2 | 0.714987 | 4 | 0 | 3 |
| PPP1R10 | TMSB15B | 0.707998 | 3 | 0 | 3 |
| PPP1R10 | ATXN7L3B | 0.705313 | 4 | 0 | 3 |
| PPP1R10 | USF1 | 0.702688 | 3 | 0 | 3 |
| PPP1R10 | MED17 | 0.702542 | 5 | 0 | 4 |
| PPP1R10 | C12orf66 | 0.702155 | 3 | 0 | 3 |
For details and further investigation, click here
