| Full name: hes related family bHLH transcription factor with YRPW motif 2 | Alias Symbol: bHLHb32|HERP1|HESR2 | ||
| Type: protein-coding gene | Cytoband: 6q22.31 | ||
| Entrez ID: 23493 | HGNC ID: HGNC:4881 | Ensembl Gene: ENSG00000135547 | OMIM ID: 604674 |
| Drug and gene relationship at DGIdb | |||
Expression of HEY2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEY2 | 23493 | 222921_s_at | 0.2111 | 0.7220 | |
| GSE20347 | HEY2 | 23493 | 219743_at | 0.2295 | 0.1647 | |
| GSE23400 | HEY2 | 23493 | 219743_at | 0.0746 | 0.0886 | |
| GSE26886 | HEY2 | 23493 | 222921_s_at | 0.7142 | 0.0527 | |
| GSE29001 | HEY2 | 23493 | 219743_at | 0.2233 | 0.4285 | |
| GSE38129 | HEY2 | 23493 | 219743_at | -0.0229 | 0.9157 | |
| GSE45670 | HEY2 | 23493 | 222921_s_at | 0.2969 | 0.0857 | |
| GSE53622 | HEY2 | 23493 | 1681 | -0.0902 | 0.5539 | |
| GSE53624 | HEY2 | 23493 | 19133 | 0.4222 | 0.0000 | |
| GSE63941 | HEY2 | 23493 | 222921_s_at | 1.5649 | 0.1473 | |
| GSE77861 | HEY2 | 23493 | 222921_s_at | 0.1591 | 0.5929 | |
| GSE97050 | HEY2 | 23493 | A_24_P363408 | 0.0568 | 0.8138 | |
| SRP007169 | HEY2 | 23493 | RNAseq | 1.8990 | 0.0436 | |
| SRP064894 | HEY2 | 23493 | RNAseq | 0.4454 | 0.0316 | |
| SRP133303 | HEY2 | 23493 | RNAseq | 0.0905 | 0.7003 | |
| SRP159526 | HEY2 | 23493 | RNAseq | 0.6514 | 0.2447 | |
| SRP219564 | HEY2 | 23493 | RNAseq | 0.2473 | 0.6529 | |
| TCGA | HEY2 | 23493 | RNAseq | 0.1612 | 0.2558 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HEY2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HEY2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEY2 | 23493 | 1 | 4 | 25 | |
| GSE20123 | HEY2 | 23493 | 2 | 3 | 25 | |
| GSE43470 | HEY2 | 23493 | 5 | 0 | 38 | |
| GSE46452 | HEY2 | 23493 | 2 | 11 | 46 | |
| GSE47630 | HEY2 | 23493 | 9 | 4 | 27 | |
| GSE54993 | HEY2 | 23493 | 4 | 2 | 64 | |
| GSE54994 | HEY2 | 23493 | 8 | 8 | 37 | |
| GSE60625 | HEY2 | 23493 | 0 | 1 | 10 | |
| GSE74703 | HEY2 | 23493 | 4 | 0 | 32 | |
| GSE74704 | HEY2 | 23493 | 0 | 1 | 19 | |
| TCGA | HEY2 | 23493 | 12 | 18 | 66 |
Total number of gains: 47; Total number of losses: 52; Total Number of normals: 389.
Somatic mutations of HEY2:
Generating mutation plots.
Highly correlated genes for HEY2:
Showing top 20/59 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEY2 | ZNF397 | 0.645853 | 3 | 0 | 3 |
| HEY2 | CCDC15 | 0.631133 | 3 | 0 | 3 |
| HEY2 | ZNF184 | 0.621551 | 3 | 0 | 3 |
| HEY2 | SLC13A5 | 0.612995 | 3 | 0 | 3 |
| HEY2 | POPDC3 | 0.612528 | 4 | 0 | 3 |
| HEY2 | SNX5 | 0.593852 | 3 | 0 | 3 |
| HEY2 | CPNE2 | 0.587694 | 3 | 0 | 3 |
| HEY2 | ZCCHC7 | 0.586748 | 3 | 0 | 3 |
| HEY2 | CCDC88A | 0.58612 | 3 | 0 | 3 |
| HEY2 | GGPS1 | 0.577146 | 4 | 0 | 3 |
| HEY2 | RNF152 | 0.565305 | 4 | 0 | 3 |
| HEY2 | SNRPB2 | 0.563143 | 3 | 0 | 3 |
| HEY2 | ZNF764 | 0.562685 | 4 | 0 | 3 |
| HEY2 | ZFP92 | 0.56215 | 4 | 0 | 3 |
| HEY2 | PLEKHA8 | 0.561692 | 4 | 0 | 3 |
| HEY2 | ARPC1B | 0.559143 | 3 | 0 | 3 |
| HEY2 | INTS7 | 0.558618 | 5 | 0 | 3 |
| HEY2 | CDH6 | 0.555348 | 5 | 0 | 3 |
| HEY2 | HOXD8 | 0.555197 | 5 | 0 | 4 |
| HEY2 | SLC25A25 | 0.550253 | 3 | 0 | 3 |
For details and further investigation, click here
