ARPC1B

 

Full name: actin related protein 2/3 complex subunit 1B Alias Symbol: ARC41|p40-ARC|p41-ARC
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 10095 HGNC ID: HGNC:704 Ensembl Gene: ENSG00000130429 OMIM ID: 604223
Drug and gene relationship at DGIdb

 

ARPC1B involved pathways:

KEGG pathway Description View
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
hsa05132Salmonella infection

 

Expression of ARPC1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARPC1B 10095 201954_at 1.4138 0.0156
GSE20347 ARPC1B 10095 201954_at 1.5385 0.0000
GSE23400 ARPC1B 10095 201954_at 1.2087 0.0000
GSE26886 ARPC1B 10095 201954_at 1.6855 0.0000
GSE29001 ARPC1B 10095 201954_at 1.4122 0.0003
GSE38129 ARPC1B 10095 201954_at 1.4540 0.0000
GSE45670 ARPC1B 10095 201954_at 1.2970 0.0001
GSE53622 ARPC1B 10095 99508 1.3287 0.0000
GSE53624 ARPC1B 10095 99508 1.5903 0.0000
GSE63941 ARPC1B 10095 201954_at -0.7283 0.2767
GSE77861 ARPC1B 10095 201954_at 1.6797 0.0008
GSE97050 ARPC1B 10095 A_23_P20196 0.9886 0.1176
SRP007169 ARPC1B 10095 RNAseq 2.0478 0.0000
SRP008496 ARPC1B 10095 RNAseq 2.2089 0.0000
SRP064894 ARPC1B 10095 RNAseq 1.9123 0.0000
SRP133303 ARPC1B 10095 RNAseq 1.7493 0.0000
SRP159526 ARPC1B 10095 RNAseq 0.8670 0.0842
SRP193095 ARPC1B 10095 RNAseq 1.5319 0.0000
SRP219564 ARPC1B 10095 RNAseq 1.4885 0.0027
TCGA ARPC1B 10095 RNAseq 0.3760 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by ARPC1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARPC1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARPC1B 10095 13 0 17
GSE20123 ARPC1B 10095 13 0 17
GSE43470 ARPC1B 10095 6 1 36
GSE46452 ARPC1B 10095 11 1 47
GSE47630 ARPC1B 10095 8 3 29
GSE54993 ARPC1B 10095 1 9 60
GSE54994 ARPC1B 10095 16 3 34
GSE60625 ARPC1B 10095 0 0 11
GSE74703 ARPC1B 10095 6 1 29
GSE74704 ARPC1B 10095 9 0 11
TCGA ARPC1B 10095 54 4 38

Total number of gains: 137; Total number of losses: 22; Total Number of normals: 329.  

 

Somatic mutations of ARPC1B:

 

Generating mutation plots.

 

Highly correlated genes for ARPC1B:

 

Showing top 20/2238 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARPC1BWDR540.822839707
ARPC1BSERPINH10.80720610010
ARPC1BMARCKSL10.79348811011
ARPC1BTTL0.788935707
ARPC1BPYCR20.787819303
ARPC1BIFITM10.7871808
ARPC1BRTKN0.785543707
ARPC1BLPCAT10.78531712011
ARPC1BPDIA50.785301303
ARPC1BVOPP10.7826612011
ARPC1BSPON20.780261303
ARPC1BPARP120.78019111011
ARPC1BTMEM184B0.7801311011
ARPC1BCDC25B0.77747611011
ARPC1BKTI120.774857303
ARPC1BTTYH30.772611707
ARPC1BTMEM1380.772158706
ARPC1BZNF4690.771903606
ARPC1BSLC25A320.77072411011
ARPC1BMSN0.77050111010

For details and further investigation, click here