| Full name: pleckstrin homology domain containing A8 | Alias Symbol: FAPP2|MGC3358 | ||
| Type: protein-coding gene | Cytoband: 7p14.3 | ||
| Entrez ID: 84725 | HGNC ID: HGNC:30037 | Ensembl Gene: ENSG00000106086 | OMIM ID: 608639 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA8 | 84725 | 227247_at | 0.3032 | 0.6816 | |
| GSE26886 | PLEKHA8 | 84725 | 227247_at | 0.6496 | 0.0599 | |
| GSE45670 | PLEKHA8 | 84725 | 227247_at | 0.6420 | 0.0001 | |
| GSE53622 | PLEKHA8 | 84725 | 8784 | 0.3133 | 0.0000 | |
| GSE53624 | PLEKHA8 | 84725 | 8784 | 0.5006 | 0.0000 | |
| GSE63941 | PLEKHA8 | 84725 | 227247_at | -0.5183 | 0.4511 | |
| GSE77861 | PLEKHA8 | 84725 | 227247_at | 0.4137 | 0.2215 | |
| GSE97050 | PLEKHA8 | 84725 | A_23_P318296 | 0.2789 | 0.3534 | |
| SRP007169 | PLEKHA8 | 84725 | RNAseq | -0.4268 | 0.2186 | |
| SRP008496 | PLEKHA8 | 84725 | RNAseq | 0.1158 | 0.7527 | |
| SRP064894 | PLEKHA8 | 84725 | RNAseq | 0.1510 | 0.4123 | |
| SRP133303 | PLEKHA8 | 84725 | RNAseq | 0.6240 | 0.0001 | |
| SRP159526 | PLEKHA8 | 84725 | RNAseq | 0.4700 | 0.0510 | |
| SRP193095 | PLEKHA8 | 84725 | RNAseq | 0.3239 | 0.0051 | |
| SRP219564 | PLEKHA8 | 84725 | RNAseq | -0.0247 | 0.9583 | |
| TCGA | PLEKHA8 | 84725 | RNAseq | 0.1191 | 0.2295 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLEKHA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA8 | 84725 | 16 | 0 | 14 | |
| GSE20123 | PLEKHA8 | 84725 | 16 | 0 | 14 | |
| GSE43470 | PLEKHA8 | 84725 | 4 | 0 | 39 | |
| GSE46452 | PLEKHA8 | 84725 | 11 | 1 | 47 | |
| GSE47630 | PLEKHA8 | 84725 | 8 | 1 | 31 | |
| GSE54993 | PLEKHA8 | 84725 | 0 | 6 | 64 | |
| GSE54994 | PLEKHA8 | 84725 | 19 | 3 | 31 | |
| GSE60625 | PLEKHA8 | 84725 | 0 | 0 | 11 | |
| GSE74703 | PLEKHA8 | 84725 | 4 | 0 | 32 | |
| GSE74704 | PLEKHA8 | 84725 | 10 | 0 | 10 | |
| TCGA | PLEKHA8 | 84725 | 55 | 7 | 34 |
Total number of gains: 143; Total number of losses: 18; Total Number of normals: 327.
Somatic mutations of PLEKHA8:
Generating mutation plots.
Highly correlated genes for PLEKHA8:
Showing top 20/869 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA8 | AFAP1L2 | 0.849483 | 3 | 0 | 3 |
| PLEKHA8 | CD109 | 0.751915 | 3 | 0 | 3 |
| PLEKHA8 | ETS2 | 0.747763 | 3 | 0 | 3 |
| PLEKHA8 | ERG | 0.735126 | 3 | 0 | 3 |
| PLEKHA8 | TARDBP | 0.724407 | 3 | 0 | 3 |
| PLEKHA8 | AAGAB | 0.722177 | 3 | 0 | 3 |
| PLEKHA8 | CLSPN | 0.718484 | 4 | 0 | 4 |
| PLEKHA8 | BORA | 0.712418 | 4 | 0 | 3 |
| PLEKHA8 | MTX3 | 0.709783 | 3 | 0 | 3 |
| PLEKHA8 | GTF3C3 | 0.705113 | 3 | 0 | 3 |
| PLEKHA8 | RAB23 | 0.703679 | 3 | 0 | 3 |
| PLEKHA8 | IDH3A | 0.702898 | 3 | 0 | 3 |
| PLEKHA8 | TARBP1 | 0.699472 | 3 | 0 | 3 |
| PLEKHA8 | HMMR | 0.699395 | 5 | 0 | 5 |
| PLEKHA8 | NOM1 | 0.696099 | 3 | 0 | 3 |
| PLEKHA8 | AMMECR1L | 0.692962 | 4 | 0 | 4 |
| PLEKHA8 | CCDC126 | 0.692268 | 3 | 0 | 3 |
| PLEKHA8 | DNMBP | 0.691902 | 3 | 0 | 3 |
| PLEKHA8 | CSE1L | 0.690242 | 3 | 0 | 3 |
| PLEKHA8 | ERH | 0.689611 | 4 | 0 | 3 |
For details and further investigation, click here
