INTS7

 

Full name: integrator complex subunit 7 Alias Symbol: DKFZP434B168|INT7
Type: protein-coding gene Cytoband: 1q32.3
Entrez ID: 25896 HGNC ID: HGNC:24484 Ensembl Gene: ENSG00000143493 OMIM ID: 611350
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of INTS7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 INTS7 25896 222250_s_at 0.5022 0.2968
GSE20347 INTS7 25896 222250_s_at 0.5838 0.0001
GSE23400 INTS7 25896 222250_s_at 0.3312 0.0000
GSE26886 INTS7 25896 222250_s_at 0.6129 0.0056
GSE29001 INTS7 25896 218783_at 0.4365 0.0703
GSE38129 INTS7 25896 222250_s_at 0.7801 0.0000
GSE45670 INTS7 25896 222250_s_at 0.7300 0.0000
GSE53622 INTS7 25896 135942 0.6702 0.0000
GSE53624 INTS7 25896 135942 0.6900 0.0000
GSE63941 INTS7 25896 222250_s_at 1.6106 0.0007
GSE77861 INTS7 25896 222250_s_at 0.4187 0.1433
GSE97050 INTS7 25896 A_23_P52082 0.7441 0.0781
SRP007169 INTS7 25896 RNAseq -0.0907 0.8188
SRP008496 INTS7 25896 RNAseq 0.0922 0.7064
SRP064894 INTS7 25896 RNAseq 0.5486 0.0037
SRP133303 INTS7 25896 RNAseq 0.6377 0.0002
SRP159526 INTS7 25896 RNAseq 0.7633 0.0056
SRP193095 INTS7 25896 RNAseq 0.1841 0.0623
SRP219564 INTS7 25896 RNAseq 0.9337 0.0162
TCGA INTS7 25896 RNAseq 0.3524 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by INTS7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of INTS7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 INTS7 25896 11 0 19
GSE20123 INTS7 25896 11 0 19
GSE43470 INTS7 25896 7 0 36
GSE46452 INTS7 25896 3 1 55
GSE47630 INTS7 25896 15 0 25
GSE54993 INTS7 25896 0 6 64
GSE54994 INTS7 25896 13 0 40
GSE60625 INTS7 25896 0 0 11
GSE74703 INTS7 25896 7 0 29
GSE74704 INTS7 25896 5 0 15
TCGA INTS7 25896 45 3 48

Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.  

 

Somatic mutations of INTS7:

 

Generating mutation plots.

 

Highly correlated genes for INTS7:

 

Showing top 20/1418 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
INTS7NUDT190.809818303
INTS7PRDM150.802064303
INTS7METAP1D0.766984303
INTS7MMS22L0.762354303
INTS7TMEM63B0.759581303
INTS7EPB41L50.758487303
INTS7CRTC20.743874303
INTS7UCK20.742386303
INTS7NCAPG0.731494808
INTS7ASPM0.7311511011
INTS7ZBTB370.728852303
INTS7ELOF10.728568303
INTS7ZNF4320.727023303
INTS7HEATR10.72640812011
INTS7LIN90.725235707
INTS7NOM10.722288404
INTS7TTK0.72227311011
INTS7KIF140.72172711011
INTS7PLEKHH10.721238303
INTS7RACGAP10.721161909

For details and further investigation, click here