| Full name: sorbin and SH3 domain containing 3 | Alias Symbol: SCAM-1|SH3D4|vinexin | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 10174 | HGNC ID: HGNC:30907 | Ensembl Gene: ENSG00000120896 | OMIM ID: 610795 |
| Drug and gene relationship at DGIdb | |||
Expression of SORBS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORBS3 | 10174 | 209253_at | 0.1260 | 0.8171 | |
| GSE20347 | SORBS3 | 10174 | 209253_at | 0.1440 | 0.1940 | |
| GSE23400 | SORBS3 | 10174 | 209253_at | -0.0165 | 0.8101 | |
| GSE26886 | SORBS3 | 10174 | 209253_at | 0.6377 | 0.0003 | |
| GSE29001 | SORBS3 | 10174 | 209253_at | -0.0769 | 0.7862 | |
| GSE38129 | SORBS3 | 10174 | 209253_at | -0.1395 | 0.3056 | |
| GSE45670 | SORBS3 | 10174 | 209253_at | -0.1691 | 0.0542 | |
| GSE53622 | SORBS3 | 10174 | 75808 | -0.2014 | 0.0008 | |
| GSE53624 | SORBS3 | 10174 | 75808 | 0.0246 | 0.6228 | |
| GSE63941 | SORBS3 | 10174 | 209253_at | 0.1934 | 0.5963 | |
| GSE77861 | SORBS3 | 10174 | 209253_at | 0.1985 | 0.4667 | |
| GSE97050 | SORBS3 | 10174 | A_33_P3409625 | -0.1118 | 0.6164 | |
| SRP007169 | SORBS3 | 10174 | RNAseq | -0.5374 | 0.1354 | |
| SRP008496 | SORBS3 | 10174 | RNAseq | -0.3829 | 0.1528 | |
| SRP064894 | SORBS3 | 10174 | RNAseq | 0.0986 | 0.7126 | |
| SRP133303 | SORBS3 | 10174 | RNAseq | -0.5139 | 0.0339 | |
| SRP159526 | SORBS3 | 10174 | RNAseq | 0.3227 | 0.3355 | |
| SRP193095 | SORBS3 | 10174 | RNAseq | 0.3958 | 0.0109 | |
| SRP219564 | SORBS3 | 10174 | RNAseq | -0.1030 | 0.8362 | |
| TCGA | SORBS3 | 10174 | RNAseq | -0.0317 | 0.5742 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SORBS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORBS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORBS3 | 10174 | 4 | 10 | 16 | |
| GSE20123 | SORBS3 | 10174 | 4 | 10 | 16 | |
| GSE43470 | SORBS3 | 10174 | 4 | 9 | 30 | |
| GSE46452 | SORBS3 | 10174 | 13 | 13 | 33 | |
| GSE47630 | SORBS3 | 10174 | 10 | 8 | 22 | |
| GSE54993 | SORBS3 | 10174 | 2 | 14 | 54 | |
| GSE54994 | SORBS3 | 10174 | 9 | 17 | 27 | |
| GSE60625 | SORBS3 | 10174 | 3 | 0 | 8 | |
| GSE74703 | SORBS3 | 10174 | 4 | 7 | 25 | |
| GSE74704 | SORBS3 | 10174 | 3 | 7 | 10 | |
| TCGA | SORBS3 | 10174 | 14 | 43 | 39 |
Total number of gains: 70; Total number of losses: 138; Total Number of normals: 280.
Somatic mutations of SORBS3:
Generating mutation plots.
Highly correlated genes for SORBS3:
Showing top 20/625 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORBS3 | TRIM47 | 0.839932 | 3 | 0 | 3 |
| SORBS3 | RAB1B | 0.814217 | 3 | 0 | 3 |
| SORBS3 | SNAPC4 | 0.803553 | 3 | 0 | 3 |
| SORBS3 | PHRF1 | 0.767774 | 3 | 0 | 3 |
| SORBS3 | KLHL13 | 0.756915 | 3 | 0 | 3 |
| SORBS3 | PELP1 | 0.753783 | 3 | 0 | 3 |
| SORBS3 | PRR12 | 0.747192 | 3 | 0 | 3 |
| SORBS3 | PLOD1 | 0.747072 | 3 | 0 | 3 |
| SORBS3 | MMP15 | 0.744595 | 3 | 0 | 3 |
| SORBS3 | R3HDM2 | 0.736134 | 4 | 0 | 4 |
| SORBS3 | CREB5 | 0.735039 | 4 | 0 | 4 |
| SORBS3 | TNFSF13 | 0.733721 | 3 | 0 | 3 |
| SORBS3 | UGGT2 | 0.733705 | 3 | 0 | 3 |
| SORBS3 | LRRCC1 | 0.732601 | 3 | 0 | 3 |
| SORBS3 | BRI3 | 0.732575 | 4 | 0 | 4 |
| SORBS3 | RAB20 | 0.732531 | 3 | 0 | 3 |
| SORBS3 | MZF1 | 0.729067 | 3 | 0 | 3 |
| SORBS3 | TLN2 | 0.728108 | 5 | 0 | 5 |
| SORBS3 | INO80E | 0.727339 | 4 | 0 | 4 |
| SORBS3 | INPP5E | 0.727293 | 3 | 0 | 3 |
For details and further investigation, click here
