| Full name: hook microtubule tethering protein 3 | Alias Symbol: HK3 | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 84376 | HGNC ID: HGNC:23576 | Ensembl Gene: ENSG00000168172 | OMIM ID: 607825 |
| Drug and gene relationship at DGIdb | |||
Expression of HOOK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOOK3 | 84376 | 226395_at | -0.4699 | 0.3093 | |
| GSE26886 | HOOK3 | 84376 | 226395_at | -0.5676 | 0.0704 | |
| GSE45670 | HOOK3 | 84376 | 226395_at | -0.6444 | 0.0000 | |
| GSE53622 | HOOK3 | 84376 | 135900 | -0.3230 | 0.0000 | |
| GSE53624 | HOOK3 | 84376 | 135900 | -0.4695 | 0.0000 | |
| GSE63941 | HOOK3 | 84376 | 226395_at | -2.1205 | 0.0015 | |
| GSE77861 | HOOK3 | 84376 | 226395_at | -0.4874 | 0.1708 | |
| GSE97050 | HOOK3 | A_19_P00318531 | -0.0195 | 0.9341 | ||
| SRP007169 | HOOK3 | 84376 | RNAseq | 0.2672 | 0.5425 | |
| SRP008496 | HOOK3 | 84376 | RNAseq | 0.3056 | 0.2613 | |
| SRP064894 | HOOK3 | 84376 | RNAseq | -0.3561 | 0.1804 | |
| SRP133303 | HOOK3 | 84376 | RNAseq | -0.1566 | 0.3017 | |
| SRP159526 | HOOK3 | 84376 | RNAseq | -0.7359 | 0.0003 | |
| SRP193095 | HOOK3 | 84376 | RNAseq | -0.3414 | 0.0113 | |
| SRP219564 | HOOK3 | 84376 | RNAseq | -0.6822 | 0.0434 | |
| TCGA | HOOK3 | 84376 | RNAseq | -0.0532 | 0.3585 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HOOK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOOK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOOK3 | 84376 | 10 | 4 | 16 | |
| GSE20123 | HOOK3 | 84376 | 10 | 4 | 16 | |
| GSE43470 | HOOK3 | 84376 | 8 | 6 | 29 | |
| GSE46452 | HOOK3 | 84376 | 20 | 5 | 34 | |
| GSE47630 | HOOK3 | 84376 | 22 | 1 | 17 | |
| GSE54993 | HOOK3 | 84376 | 1 | 16 | 53 | |
| GSE54994 | HOOK3 | 84376 | 18 | 8 | 27 | |
| GSE60625 | HOOK3 | 84376 | 3 | 0 | 8 | |
| GSE74703 | HOOK3 | 84376 | 7 | 5 | 24 | |
| GSE74704 | HOOK3 | 84376 | 9 | 1 | 10 | |
| TCGA | HOOK3 | 84376 | 38 | 21 | 37 |
Total number of gains: 146; Total number of losses: 71; Total Number of normals: 271.
Somatic mutations of HOOK3:
Generating mutation plots.
Highly correlated genes for HOOK3:
Showing top 20/857 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOOK3 | GIN1 | 0.802085 | 3 | 0 | 3 |
| HOOK3 | DPY19L3 | 0.779981 | 3 | 0 | 3 |
| HOOK3 | GK5 | 0.778485 | 3 | 0 | 3 |
| HOOK3 | ZCCHC10 | 0.775288 | 3 | 0 | 3 |
| HOOK3 | NAA35 | 0.769265 | 3 | 0 | 3 |
| HOOK3 | PPP3CC | 0.765074 | 6 | 0 | 6 |
| HOOK3 | UGP2 | 0.757121 | 4 | 0 | 4 |
| HOOK3 | PIK3C3 | 0.754878 | 3 | 0 | 3 |
| HOOK3 | PSEN2 | 0.754436 | 3 | 0 | 3 |
| HOOK3 | TRIP11 | 0.752064 | 3 | 0 | 3 |
| HOOK3 | PTGER2 | 0.750645 | 3 | 0 | 3 |
| HOOK3 | ZFAND1 | 0.750426 | 3 | 0 | 3 |
| HOOK3 | DLD | 0.747506 | 3 | 0 | 3 |
| HOOK3 | ERI2 | 0.746818 | 3 | 0 | 3 |
| HOOK3 | PPP1R8 | 0.742818 | 3 | 0 | 3 |
| HOOK3 | ARHGEF6 | 0.742415 | 3 | 0 | 3 |
| HOOK3 | MTM1 | 0.733794 | 3 | 0 | 3 |
| HOOK3 | PDSS2 | 0.733784 | 3 | 0 | 3 |
| HOOK3 | WDR36 | 0.733044 | 4 | 0 | 4 |
| HOOK3 | LACTB | 0.732425 | 3 | 0 | 3 |
For details and further investigation, click here
