| Full name: prostaglandin E receptor 2 | Alias Symbol: EP2 | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 5732 | HGNC ID: HGNC:9594 | Ensembl Gene: ENSG00000125384 | OMIM ID: 176804 |
| Drug and gene relationship at DGIdb | |||
PTGER2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04750 | Inflammatory mediator regulation of TRP channels | |
| hsa04924 | Renin secretion |
Expression of PTGER2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTGER2 | 5732 | 206631_at | -0.3356 | 0.5745 | |
| GSE20347 | PTGER2 | 5732 | 206631_at | 0.0228 | 0.7341 | |
| GSE23400 | PTGER2 | 5732 | 206631_at | -0.0253 | 0.5302 | |
| GSE26886 | PTGER2 | 5732 | 206631_at | 0.2044 | 0.1785 | |
| GSE29001 | PTGER2 | 5732 | 206631_at | 0.0462 | 0.8629 | |
| GSE38129 | PTGER2 | 5732 | 206631_at | -0.1376 | 0.4974 | |
| GSE45670 | PTGER2 | 5732 | 206631_at | -0.8060 | 0.0000 | |
| GSE53622 | PTGER2 | 5732 | 50857 | -0.7789 | 0.0002 | |
| GSE53624 | PTGER2 | 5732 | 50857 | -0.6149 | 0.0054 | |
| GSE63941 | PTGER2 | 5732 | 206631_at | -4.3835 | 0.0000 | |
| GSE77861 | PTGER2 | 5732 | 206631_at | -0.0177 | 0.8372 | |
| GSE97050 | PTGER2 | 5732 | A_23_P151710 | -0.2190 | 0.4298 | |
| SRP064894 | PTGER2 | 5732 | RNAseq | 0.1108 | 0.7196 | |
| SRP133303 | PTGER2 | 5732 | RNAseq | -0.5572 | 0.1681 | |
| SRP159526 | PTGER2 | 5732 | RNAseq | 0.4357 | 0.5416 | |
| SRP219564 | PTGER2 | 5732 | RNAseq | 0.7377 | 0.2596 | |
| TCGA | PTGER2 | 5732 | RNAseq | -1.4312 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PTGER2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTGER2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTGER2 | 5732 | 8 | 3 | 19 | |
| GSE20123 | PTGER2 | 5732 | 8 | 3 | 19 | |
| GSE43470 | PTGER2 | 5732 | 9 | 1 | 33 | |
| GSE46452 | PTGER2 | 5732 | 16 | 3 | 40 | |
| GSE47630 | PTGER2 | 5732 | 11 | 10 | 19 | |
| GSE54993 | PTGER2 | 5732 | 3 | 8 | 59 | |
| GSE54994 | PTGER2 | 5732 | 19 | 4 | 30 | |
| GSE60625 | PTGER2 | 5732 | 0 | 2 | 9 | |
| GSE74703 | PTGER2 | 5732 | 8 | 1 | 27 | |
| GSE74704 | PTGER2 | 5732 | 3 | 2 | 15 | |
| TCGA | PTGER2 | 5732 | 34 | 12 | 50 |
Total number of gains: 119; Total number of losses: 49; Total Number of normals: 320.
Somatic mutations of PTGER2:
Generating mutation plots.
Highly correlated genes for PTGER2:
Showing top 20/823 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTGER2 | HGF | 0.80146 | 4 | 0 | 4 |
| PTGER2 | GIMAP5 | 0.776295 | 3 | 0 | 3 |
| PTGER2 | CD99L2 | 0.760768 | 3 | 0 | 3 |
| PTGER2 | GLIS3 | 0.758094 | 3 | 0 | 3 |
| PTGER2 | HOOK3 | 0.750645 | 3 | 0 | 3 |
| PTGER2 | ZNF844 | 0.74483 | 3 | 0 | 3 |
| PTGER2 | MRVI1 | 0.739894 | 4 | 0 | 4 |
| PTGER2 | FIBIN | 0.7365 | 4 | 0 | 3 |
| PTGER2 | TCEAL6 | 0.729048 | 3 | 0 | 3 |
| PTGER2 | RCSD1 | 0.724123 | 5 | 0 | 5 |
| PTGER2 | FAM124A | 0.716691 | 3 | 0 | 3 |
| PTGER2 | PDE7B | 0.71486 | 7 | 0 | 7 |
| PTGER2 | SCUBE3 | 0.712398 | 4 | 0 | 3 |
| PTGER2 | GIMAP8 | 0.710199 | 5 | 0 | 5 |
| PTGER2 | GNG2 | 0.707235 | 6 | 0 | 5 |
| PTGER2 | SLC30A5 | 0.707073 | 3 | 0 | 3 |
| PTGER2 | INMT | 0.705605 | 4 | 0 | 3 |
| PTGER2 | C1QTNF7 | 0.703916 | 4 | 0 | 4 |
| PTGER2 | UNC5C | 0.702949 | 6 | 0 | 5 |
| PTGER2 | CYP2U1 | 0.702276 | 6 | 0 | 6 |
For details and further investigation, click here
