| Full name: Rac/Cdc42 guanine nucleotide exchange factor 6 | Alias Symbol: alphaPIX|Cool-2|KIAA0006|alpha-PIX|Cool2|αPix | ||
| Type: protein-coding gene | Cytoband: Xq26.3 | ||
| Entrez ID: 9459 | HGNC ID: HGNC:685 | Ensembl Gene: ENSG00000129675 | OMIM ID: 300267 |
| Drug and gene relationship at DGIdb | |||
ARHGEF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05212 | Pancreatic cancer |
Expression of ARHGEF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF6 | 9459 | 209539_at | -0.5349 | 0.4637 | |
| GSE20347 | ARHGEF6 | 9459 | 209539_at | -0.3906 | 0.0289 | |
| GSE23400 | ARHGEF6 | 9459 | 209539_at | -0.2798 | 0.0002 | |
| GSE26886 | ARHGEF6 | 9459 | 209539_at | -0.3164 | 0.3820 | |
| GSE29001 | ARHGEF6 | 9459 | 209539_at | -0.3779 | 0.3252 | |
| GSE38129 | ARHGEF6 | 9459 | 209539_at | -0.7030 | 0.0058 | |
| GSE45670 | ARHGEF6 | 9459 | 209539_at | -1.2107 | 0.0001 | |
| GSE53622 | ARHGEF6 | 9459 | 74480 | -0.2462 | 0.0242 | |
| GSE53624 | ARHGEF6 | 9459 | 74480 | -0.4125 | 0.0060 | |
| GSE63941 | ARHGEF6 | 9459 | 209539_at | -3.1978 | 0.0000 | |
| GSE77861 | ARHGEF6 | 9459 | 209539_at | -0.2571 | 0.0160 | |
| GSE97050 | ARHGEF6 | 9459 | A_24_P228875 | 0.0941 | 0.7900 | |
| SRP007169 | ARHGEF6 | 9459 | RNAseq | 0.5990 | 0.2498 | |
| SRP008496 | ARHGEF6 | 9459 | RNAseq | 0.5256 | 0.1101 | |
| SRP064894 | ARHGEF6 | 9459 | RNAseq | -0.0363 | 0.9052 | |
| SRP133303 | ARHGEF6 | 9459 | RNAseq | -0.1647 | 0.4518 | |
| SRP159526 | ARHGEF6 | 9459 | RNAseq | -0.1384 | 0.7646 | |
| SRP193095 | ARHGEF6 | 9459 | RNAseq | -0.0914 | 0.6752 | |
| SRP219564 | ARHGEF6 | 9459 | RNAseq | 0.0282 | 0.9537 | |
| TCGA | ARHGEF6 | 9459 | RNAseq | -0.4643 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ARHGEF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF6:
No record found for this gene.
Somatic mutations of ARHGEF6:
Generating mutation plots.
Highly correlated genes for ARHGEF6:
Showing top 20/1359 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF6 | ANKRD44 | 0.810777 | 6 | 0 | 6 |
| ARHGEF6 | RCSD1 | 0.808229 | 7 | 0 | 7 |
| ARHGEF6 | ARHGAP15 | 0.800263 | 4 | 0 | 4 |
| ARHGEF6 | APOB | 0.776948 | 4 | 0 | 4 |
| ARHGEF6 | STAM | 0.76894 | 3 | 0 | 3 |
| ARHGEF6 | ARHGAP31 | 0.763108 | 6 | 0 | 5 |
| ARHGEF6 | NLGN4X | 0.763061 | 3 | 0 | 3 |
| ARHGEF6 | MAP4 | 0.759694 | 4 | 0 | 4 |
| ARHGEF6 | TK2 | 0.756043 | 4 | 0 | 4 |
| ARHGEF6 | CNRIP1 | 0.753897 | 7 | 0 | 6 |
| ARHGEF6 | FIBIN | 0.753803 | 5 | 0 | 5 |
| ARHGEF6 | GIMAP5 | 0.753661 | 4 | 0 | 4 |
| ARHGEF6 | LINC01279 | 0.753314 | 4 | 0 | 4 |
| ARHGEF6 | C11orf96 | 0.752669 | 4 | 0 | 4 |
| ARHGEF6 | GNL3 | 0.751866 | 3 | 0 | 3 |
| ARHGEF6 | ABCD2 | 0.748086 | 4 | 0 | 4 |
| ARHGEF6 | EPHA3 | 0.747733 | 6 | 0 | 6 |
| ARHGEF6 | CELF2 | 0.746384 | 11 | 0 | 10 |
| ARHGEF6 | HOOK3 | 0.742415 | 3 | 0 | 3 |
| ARHGEF6 | TMEM120A | 0.741487 | 3 | 0 | 3 |
For details and further investigation, click here
