| Full name: dihydrolipoamide dehydrogenase | Alias Symbol: DLDH|E3 | ||
| Type: protein-coding gene | Cytoband: 7q31.1 | ||
| Entrez ID: 1738 | HGNC ID: HGNC:2898 | Ensembl Gene: ENSG00000091140 | OMIM ID: 238331 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DLD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLD | 1738 | 209095_at | -0.6027 | 0.1683 | |
| GSE20347 | DLD | 1738 | 209095_at | 0.0458 | 0.8646 | |
| GSE23400 | DLD | 1738 | 209095_at | 0.0458 | 0.6854 | |
| GSE26886 | DLD | 1738 | 209095_at | -0.6947 | 0.0346 | |
| GSE29001 | DLD | 1738 | 209095_at | -0.0616 | 0.9211 | |
| GSE38129 | DLD | 1738 | 209095_at | 0.0073 | 0.9692 | |
| GSE45670 | DLD | 1738 | 209095_at | -0.0474 | 0.8140 | |
| GSE53622 | DLD | 1738 | 64520 | -0.1103 | 0.2983 | |
| GSE53624 | DLD | 1738 | 64520 | -0.0051 | 0.9548 | |
| GSE63941 | DLD | 1738 | 209095_at | 0.2770 | 0.5712 | |
| GSE77861 | DLD | 1738 | 209095_at | -0.0909 | 0.8630 | |
| GSE97050 | DLD | 1738 | A_33_P3344579 | -0.1564 | 0.6209 | |
| SRP007169 | DLD | 1738 | RNAseq | 0.1051 | 0.7319 | |
| SRP008496 | DLD | 1738 | RNAseq | 0.1308 | 0.5330 | |
| SRP064894 | DLD | 1738 | RNAseq | -0.2908 | 0.0199 | |
| SRP133303 | DLD | 1738 | RNAseq | -0.0033 | 0.9831 | |
| SRP159526 | DLD | 1738 | RNAseq | 0.0613 | 0.8762 | |
| SRP193095 | DLD | 1738 | RNAseq | -0.2758 | 0.0188 | |
| SRP219564 | DLD | 1738 | RNAseq | -0.2581 | 0.5295 | |
| TCGA | DLD | 1738 | RNAseq | -0.1259 | 0.0118 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DLD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLD | 1738 | 11 | 0 | 19 | |
| GSE20123 | DLD | 1738 | 11 | 0 | 19 | |
| GSE43470 | DLD | 1738 | 6 | 2 | 35 | |
| GSE46452 | DLD | 1738 | 10 | 1 | 48 | |
| GSE47630 | DLD | 1738 | 8 | 3 | 29 | |
| GSE54993 | DLD | 1738 | 2 | 9 | 59 | |
| GSE54994 | DLD | 1738 | 16 | 3 | 34 | |
| GSE60625 | DLD | 1738 | 0 | 0 | 11 | |
| GSE74703 | DLD | 1738 | 6 | 2 | 28 | |
| GSE74704 | DLD | 1738 | 7 | 0 | 13 | |
| TCGA | DLD | 1738 | 51 | 10 | 35 |
Total number of gains: 128; Total number of losses: 30; Total Number of normals: 330.
Somatic mutations of DLD:
Generating mutation plots.
Highly correlated genes for DLD:
Showing top 20/775 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLD | HDAC3 | 0.789867 | 3 | 0 | 3 |
| DLD | AK3 | 0.789032 | 4 | 0 | 4 |
| DLD | BRK1 | 0.785475 | 3 | 0 | 3 |
| DLD | SPATA6 | 0.781983 | 3 | 0 | 3 |
| DLD | STX18 | 0.770751 | 3 | 0 | 3 |
| DLD | PLEKHF2 | 0.764301 | 4 | 0 | 4 |
| DLD | BTD | 0.756436 | 3 | 0 | 3 |
| DLD | GIN1 | 0.754985 | 4 | 0 | 4 |
| DLD | SEC22B | 0.753246 | 3 | 0 | 3 |
| DLD | MSRA | 0.748781 | 3 | 0 | 3 |
| DLD | HOOK3 | 0.747506 | 3 | 0 | 3 |
| DLD | SLC9A6 | 0.747007 | 3 | 0 | 3 |
| DLD | UBR2 | 0.746734 | 4 | 0 | 4 |
| DLD | TMX4 | 0.742747 | 3 | 0 | 3 |
| DLD | TMEM219 | 0.737255 | 3 | 0 | 3 |
| DLD | TET2 | 0.733093 | 3 | 0 | 3 |
| DLD | SARNP | 0.732079 | 3 | 0 | 3 |
| DLD | EIF3I | 0.731003 | 3 | 0 | 3 |
| DLD | CEP57 | 0.722498 | 3 | 0 | 3 |
| DLD | SGMS1 | 0.72223 | 4 | 0 | 4 |
For details and further investigation, click here
