| Full name: HOX transcript antisense RNA | Alias Symbol: HOXC-AS4|HOXC11-AS1|NCRNA00072 | ||
| Type: non-coding RNA | Cytoband: 12q13.13 | ||
| Entrez ID: 100124700 | HGNC ID: HGNC:33510 | Ensembl Gene: ENSG00000228630 | OMIM ID: 611400 |
| Drug and gene relationship at DGIdb | |||
Expression of HOTAIR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOTAIR | 100124700 | 239153_at | 0.5070 | 0.3864 | |
| GSE26886 | HOTAIR | 100124700 | 239153_at | 0.4635 | 0.0172 | |
| GSE45670 | HOTAIR | 100124700 | 239153_at | 0.6059 | 0.1395 | |
| GSE53622 | HOTAIR | 100124700 | 35917 | 1.1207 | 0.0000 | |
| GSE53624 | HOTAIR | 100124700 | 35644 | 0.7198 | 0.0000 | |
| GSE63941 | HOTAIR | 100124700 | 239153_at | 0.7820 | 0.2456 | |
| GSE77861 | HOTAIR | 100124700 | 239153_at | 0.0039 | 0.9666 | |
| GSE97050 | HOTAIR | A_21_P0010504 | -0.0633 | 0.8075 | ||
| TCGA | HOTAIR | 100124700 | RNAseq | 2.7436 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HOTAIR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOTAIR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOTAIR | 100124700 | 4 | 1 | 25 | |
| GSE20123 | HOTAIR | 100124700 | 4 | 1 | 25 | |
| GSE43470 | HOTAIR | 100124700 | 3 | 0 | 40 | |
| GSE46452 | HOTAIR | 100124700 | 7 | 1 | 51 | |
| GSE47630 | HOTAIR | 100124700 | 10 | 2 | 28 | |
| GSE54993 | HOTAIR | 100124700 | 0 | 5 | 65 | |
| GSE54994 | HOTAIR | 100124700 | 4 | 1 | 48 | |
| GSE60625 | HOTAIR | 100124700 | 0 | 0 | 11 | |
| GSE74703 | HOTAIR | 100124700 | 3 | 0 | 33 | |
| GSE74704 | HOTAIR | 100124700 | 3 | 1 | 16 | |
| TCGA | HOTAIR | 100124700 | 15 | 12 | 69 |
Total number of gains: 53; Total number of losses: 24; Total Number of normals: 411.
Somatic mutations of HOTAIR:
Generating mutation plots.
Highly correlated genes for HOTAIR:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOTAIR | TIGD5 | 0.808139 | 3 | 0 | 3 |
| HOTAIR | GSDMD | 0.792166 | 3 | 0 | 3 |
| HOTAIR | CDH4 | 0.775552 | 3 | 0 | 3 |
| HOTAIR | GPT | 0.773263 | 3 | 0 | 3 |
| HOTAIR | SLC22A31 | 0.771525 | 3 | 0 | 3 |
| HOTAIR | TDRD9 | 0.768879 | 4 | 0 | 3 |
| HOTAIR | HDAC8 | 0.720049 | 3 | 0 | 3 |
| HOTAIR | ZMYND15 | 0.717412 | 4 | 0 | 3 |
| HOTAIR | ANKLE1 | 0.697737 | 3 | 0 | 3 |
| HOTAIR | TMEM120B | 0.697494 | 3 | 0 | 3 |
| HOTAIR | NAT14 | 0.696222 | 4 | 0 | 3 |
| HOTAIR | LONP1 | 0.695632 | 3 | 0 | 3 |
| HOTAIR | PNMA6A | 0.695316 | 4 | 0 | 4 |
| HOTAIR | PUS1 | 0.69512 | 3 | 0 | 3 |
| HOTAIR | SLC22A11 | 0.69303 | 3 | 0 | 3 |
| HOTAIR | MYLK2 | 0.692933 | 3 | 0 | 3 |
| HOTAIR | UBL4A | 0.691029 | 3 | 0 | 3 |
| HOTAIR | ZNF205 | 0.689351 | 3 | 0 | 3 |
| HOTAIR | FFAR1 | 0.684569 | 3 | 0 | 3 |
| HOTAIR | PCSK1N | 0.683905 | 4 | 0 | 3 |
For details and further investigation, click here
