| Full name: gasdermin D | Alias Symbol: FLJ12150|DF5L | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 79792 | HGNC ID: HGNC:25697 | Ensembl Gene: ENSG00000104518 | OMIM ID: 617042 |
| Drug and gene relationship at DGIdb | |||
Expression of GSDMD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSDMD | 79792 | 218154_at | 0.6136 | 0.1825 | |
| GSE20347 | GSDMD | 79792 | 218154_at | 0.6157 | 0.0000 | |
| GSE23400 | GSDMD | 79792 | 218154_at | 0.4229 | 0.0000 | |
| GSE26886 | GSDMD | 79792 | 218154_at | 1.2610 | 0.0000 | |
| GSE29001 | GSDMD | 79792 | 218154_at | 0.5372 | 0.0080 | |
| GSE38129 | GSDMD | 79792 | 218154_at | 0.3831 | 0.0039 | |
| GSE45670 | GSDMD | 79792 | 218154_at | 0.5676 | 0.0048 | |
| GSE53622 | GSDMD | 79792 | 18954 | 0.5470 | 0.0000 | |
| GSE53624 | GSDMD | 79792 | 18954 | 0.7644 | 0.0000 | |
| GSE63941 | GSDMD | 79792 | 218154_at | 0.3608 | 0.2833 | |
| GSE77861 | GSDMD | 79792 | 218154_at | 0.1272 | 0.4758 | |
| GSE97050 | GSDMD | 79792 | A_23_P112103 | 0.4485 | 0.1838 | |
| SRP007169 | GSDMD | 79792 | RNAseq | 2.2195 | 0.0010 | |
| SRP008496 | GSDMD | 79792 | RNAseq | 2.6424 | 0.0000 | |
| SRP064894 | GSDMD | 79792 | RNAseq | 1.5729 | 0.0000 | |
| SRP133303 | GSDMD | 79792 | RNAseq | 0.5179 | 0.0068 | |
| SRP159526 | GSDMD | 79792 | RNAseq | 0.6537 | 0.0066 | |
| SRP193095 | GSDMD | 79792 | RNAseq | 0.5435 | 0.0202 | |
| SRP219564 | GSDMD | 79792 | RNAseq | 1.3876 | 0.0139 | |
| TCGA | GSDMD | 79792 | RNAseq | 0.1839 | 0.0079 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by GSDMD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSDMD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSDMD | 79792 | 17 | 1 | 12 | |
| GSE20123 | GSDMD | 79792 | 17 | 1 | 12 | |
| GSE43470 | GSDMD | 79792 | 17 | 2 | 24 | |
| GSE46452 | GSDMD | 79792 | 27 | 0 | 32 | |
| GSE47630 | GSDMD | 79792 | 23 | 1 | 16 | |
| GSE54993 | GSDMD | 79792 | 0 | 25 | 45 | |
| GSE54994 | GSDMD | 79792 | 39 | 1 | 13 | |
| GSE60625 | GSDMD | 79792 | 3 | 4 | 4 | |
| GSE74703 | GSDMD | 79792 | 15 | 1 | 20 | |
| GSE74704 | GSDMD | 79792 | 10 | 0 | 10 | |
| TCGA | GSDMD | 79792 | 64 | 2 | 30 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of GSDMD:
Generating mutation plots.
Highly correlated genes for GSDMD:
Showing top 20/657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSDMD | HOTAIR | 0.792166 | 3 | 0 | 3 |
| GSDMD | ARL8A | 0.737778 | 3 | 0 | 3 |
| GSDMD | CPAMD8 | 0.733696 | 4 | 0 | 4 |
| GSDMD | ADAP1 | 0.730557 | 3 | 0 | 3 |
| GSDMD | NAT14 | 0.72858 | 6 | 0 | 5 |
| GSDMD | PRR18 | 0.725224 | 3 | 0 | 3 |
| GSDMD | ZBTB46 | 0.719077 | 3 | 0 | 3 |
| GSDMD | TRIM17 | 0.718068 | 3 | 0 | 3 |
| GSDMD | SHISA8 | 0.703389 | 4 | 0 | 4 |
| GSDMD | DYRK1B | 0.693179 | 3 | 0 | 3 |
| GSDMD | PRR15 | 0.688038 | 3 | 0 | 3 |
| GSDMD | BMF | 0.685184 | 5 | 0 | 4 |
| GSDMD | CTHRC1 | 0.683931 | 5 | 0 | 5 |
| GSDMD | HCN3 | 0.679546 | 3 | 0 | 3 |
| GSDMD | MFAP2 | 0.679419 | 9 | 0 | 9 |
| GSDMD | HMX1 | 0.678277 | 3 | 0 | 3 |
| GSDMD | ZMYND15 | 0.67532 | 6 | 0 | 5 |
| GSDMD | PARP10 | 0.66775 | 6 | 0 | 5 |
| GSDMD | LIME1 | 0.667379 | 5 | 0 | 4 |
| GSDMD | PTGER1 | 0.666929 | 3 | 0 | 3 |
For details and further investigation, click here
