| Full name: lon peptidase 1, mitochondrial | Alias Symbol: LonHS|hLON|PIM1 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 9361 | HGNC ID: HGNC:9479 | Ensembl Gene: ENSG00000196365 | OMIM ID: 605490 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LONP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LONP1 | 9361 | 209017_s_at | 0.6369 | 0.0523 | |
| GSE20347 | LONP1 | 9361 | 209017_s_at | 0.7043 | 0.0000 | |
| GSE23400 | LONP1 | 9361 | 209017_s_at | 0.4624 | 0.0000 | |
| GSE26886 | LONP1 | 9361 | 209017_s_at | 0.9825 | 0.0000 | |
| GSE29001 | LONP1 | 9361 | 209017_s_at | 0.5715 | 0.0234 | |
| GSE38129 | LONP1 | 9361 | 209017_s_at | 0.6609 | 0.0000 | |
| GSE45670 | LONP1 | 9361 | 209017_s_at | 0.4788 | 0.0032 | |
| GSE53622 | LONP1 | 9361 | 11411 | 0.3267 | 0.0000 | |
| GSE53624 | LONP1 | 9361 | 11411 | 0.5637 | 0.0000 | |
| GSE63941 | LONP1 | 9361 | 209017_s_at | -0.0347 | 0.9624 | |
| GSE77861 | LONP1 | 9361 | 209017_s_at | 0.8273 | 0.0008 | |
| GSE97050 | LONP1 | 9361 | A_33_P3312365 | 0.1889 | 0.3736 | |
| SRP007169 | LONP1 | 9361 | RNAseq | 1.7333 | 0.0003 | |
| SRP008496 | LONP1 | 9361 | RNAseq | 1.7720 | 0.0000 | |
| SRP064894 | LONP1 | 9361 | RNAseq | 1.0351 | 0.0000 | |
| SRP133303 | LONP1 | 9361 | RNAseq | 0.5303 | 0.0125 | |
| SRP159526 | LONP1 | 9361 | RNAseq | 0.6750 | 0.0019 | |
| SRP193095 | LONP1 | 9361 | RNAseq | 0.7692 | 0.0000 | |
| SRP219564 | LONP1 | 9361 | RNAseq | 0.4948 | 0.1316 | |
| TCGA | LONP1 | 9361 | RNAseq | 0.0040 | 0.9301 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LONP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LONP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LONP1 | 9361 | 5 | 3 | 22 | |
| GSE20123 | LONP1 | 9361 | 4 | 2 | 24 | |
| GSE43470 | LONP1 | 9361 | 2 | 6 | 35 | |
| GSE46452 | LONP1 | 9361 | 47 | 1 | 11 | |
| GSE47630 | LONP1 | 9361 | 5 | 7 | 28 | |
| GSE54993 | LONP1 | 9361 | 16 | 3 | 51 | |
| GSE54994 | LONP1 | 9361 | 6 | 16 | 31 | |
| GSE60625 | LONP1 | 9361 | 9 | 0 | 2 | |
| GSE74703 | LONP1 | 9361 | 2 | 4 | 30 | |
| GSE74704 | LONP1 | 9361 | 1 | 2 | 17 | |
| TCGA | LONP1 | 9361 | 10 | 18 | 68 |
Total number of gains: 107; Total number of losses: 62; Total Number of normals: 319.
Somatic mutations of LONP1:
Generating mutation plots.
Highly correlated genes for LONP1:
Showing top 20/659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LONP1 | HOXC9 | 0.819878 | 5 | 0 | 5 |
| LONP1 | FBRSL1 | 0.801503 | 5 | 0 | 5 |
| LONP1 | MBD6 | 0.797882 | 3 | 0 | 3 |
| LONP1 | CPAMD8 | 0.79604 | 3 | 0 | 3 |
| LONP1 | RTEL1 | 0.773617 | 3 | 0 | 3 |
| LONP1 | RHPN2 | 0.760592 | 5 | 0 | 5 |
| LONP1 | BEND3 | 0.756897 | 7 | 0 | 6 |
| LONP1 | INTS5 | 0.749387 | 3 | 0 | 3 |
| LONP1 | COLGALT1 | 0.748692 | 10 | 0 | 10 |
| LONP1 | NAT14 | 0.74408 | 7 | 0 | 6 |
| LONP1 | UBE2S | 0.735778 | 9 | 0 | 8 |
| LONP1 | CHAF1A | 0.731667 | 9 | 0 | 9 |
| LONP1 | SLC4A11 | 0.730427 | 3 | 0 | 3 |
| LONP1 | PUS1 | 0.729319 | 10 | 0 | 9 |
| LONP1 | ARHGAP22 | 0.726292 | 4 | 0 | 3 |
| LONP1 | ALKBH5 | 0.724522 | 3 | 0 | 3 |
| LONP1 | PGP | 0.71989 | 5 | 0 | 5 |
| LONP1 | CCT3 | 0.710592 | 10 | 0 | 9 |
| LONP1 | IGSF9 | 0.709157 | 5 | 0 | 5 |
| LONP1 | CMSS1 | 0.705976 | 6 | 0 | 6 |
For details and further investigation, click here
