| Full name: pseudouridine synthase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 80324 | HGNC ID: HGNC:15508 | Ensembl Gene: ENSG00000177192 | OMIM ID: 608109 |
| Drug and gene relationship at DGIdb | |||
Expression of PUS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PUS1 | 80324 | 218670_at | 1.1684 | 0.0265 | |
| GSE20347 | PUS1 | 80324 | 218670_at | 0.7963 | 0.0001 | |
| GSE23400 | PUS1 | 80324 | 218670_at | 0.6619 | 0.0000 | |
| GSE26886 | PUS1 | 80324 | 218670_at | 1.0016 | 0.0000 | |
| GSE29001 | PUS1 | 80324 | 218670_at | 0.9512 | 0.0076 | |
| GSE38129 | PUS1 | 80324 | 218670_at | 0.9080 | 0.0000 | |
| GSE45670 | PUS1 | 80324 | 218670_at | 0.7475 | 0.0000 | |
| GSE53622 | PUS1 | 80324 | 53022 | 0.0061 | 0.9569 | |
| GSE53624 | PUS1 | 80324 | 53022 | 0.4277 | 0.0000 | |
| GSE63941 | PUS1 | 80324 | 218670_at | 0.9022 | 0.0136 | |
| GSE77861 | PUS1 | 80324 | 218670_at | 0.9481 | 0.0100 | |
| GSE97050 | PUS1 | 80324 | A_24_P335358 | 0.4324 | 0.3405 | |
| SRP007169 | PUS1 | 80324 | RNAseq | 2.0029 | 0.0018 | |
| SRP008496 | PUS1 | 80324 | RNAseq | 2.5113 | 0.0000 | |
| SRP064894 | PUS1 | 80324 | RNAseq | 0.8179 | 0.0004 | |
| SRP133303 | PUS1 | 80324 | RNAseq | 0.4955 | 0.0028 | |
| SRP159526 | PUS1 | 80324 | RNAseq | 0.8917 | 0.0100 | |
| SRP193095 | PUS1 | 80324 | RNAseq | 0.5418 | 0.0000 | |
| SRP219564 | PUS1 | 80324 | RNAseq | 0.7231 | 0.1242 | |
| TCGA | PUS1 | 80324 | RNAseq | 0.3497 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PUS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PUS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PUS1 | 80324 | 4 | 5 | 21 | |
| GSE20123 | PUS1 | 80324 | 4 | 5 | 21 | |
| GSE43470 | PUS1 | 80324 | 3 | 3 | 37 | |
| GSE46452 | PUS1 | 80324 | 8 | 3 | 48 | |
| GSE47630 | PUS1 | 80324 | 9 | 3 | 28 | |
| GSE54993 | PUS1 | 80324 | 0 | 6 | 64 | |
| GSE54994 | PUS1 | 80324 | 4 | 8 | 41 | |
| GSE60625 | PUS1 | 80324 | 0 | 0 | 11 | |
| GSE74703 | PUS1 | 80324 | 2 | 3 | 31 | |
| GSE74704 | PUS1 | 80324 | 2 | 3 | 15 | |
| TCGA | PUS1 | 80324 | 23 | 14 | 59 |
Total number of gains: 59; Total number of losses: 53; Total Number of normals: 376.
Somatic mutations of PUS1:
Generating mutation plots.
Highly correlated genes for PUS1:
Showing top 20/721 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PUS1 | FBRSL1 | 0.78741 | 6 | 0 | 6 |
| PUS1 | SCYL1 | 0.764055 | 4 | 0 | 4 |
| PUS1 | RBM28 | 0.748719 | 9 | 0 | 9 |
| PUS1 | HOXC9 | 0.742616 | 6 | 0 | 5 |
| PUS1 | FAM24B | 0.742554 | 3 | 0 | 3 |
| PUS1 | MTERF3 | 0.738535 | 8 | 0 | 7 |
| PUS1 | LONP1 | 0.729319 | 10 | 0 | 9 |
| PUS1 | PGP | 0.727739 | 5 | 0 | 5 |
| PUS1 | BUB1B | 0.726782 | 9 | 0 | 9 |
| PUS1 | CCT3 | 0.722912 | 9 | 0 | 9 |
| PUS1 | RHPN2 | 0.715035 | 5 | 0 | 5 |
| PUS1 | DHX9 | 0.714609 | 11 | 0 | 10 |
| PUS1 | IPO9 | 0.709374 | 9 | 0 | 9 |
| PUS1 | CPAMD8 | 0.708524 | 3 | 0 | 3 |
| PUS1 | POLR2H | 0.705924 | 10 | 0 | 9 |
| PUS1 | CDC6 | 0.704015 | 8 | 0 | 7 |
| PUS1 | KIF4A | 0.703282 | 10 | 0 | 8 |
| PUS1 | RFT1 | 0.702836 | 4 | 0 | 3 |
| PUS1 | CDCA5 | 0.702692 | 7 | 0 | 5 |
| PUS1 | UBE2T | 0.70268 | 6 | 0 | 5 |
For details and further investigation, click here
