| Full name: glutamic--pyruvic transaminase | Alias Symbol: ALT1|GPT1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 2875 | HGNC ID: HGNC:4552 | Ensembl Gene: ENSG00000167701 | OMIM ID: 138200 |
| Drug and gene relationship at DGIdb | |||
Expression of GPT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPT | 2875 | 206709_x_at | 0.1023 | 0.8476 | |
| GSE20347 | GPT | 2875 | 206709_x_at | -0.1762 | 0.0513 | |
| GSE23400 | GPT | 2875 | 206709_x_at | -0.3506 | 0.0000 | |
| GSE26886 | GPT | 2875 | 206709_x_at | -0.1349 | 0.3723 | |
| GSE29001 | GPT | 2875 | 206709_x_at | -0.0143 | 0.9387 | |
| GSE38129 | GPT | 2875 | 206709_x_at | -0.1748 | 0.0401 | |
| GSE45670 | GPT | 2875 | 206709_x_at | -0.2418 | 0.0017 | |
| GSE53622 | GPT | 2875 | 30705 | -0.4634 | 0.0000 | |
| GSE53624 | GPT | 2875 | 30705 | -0.5458 | 0.0000 | |
| GSE63941 | GPT | 2875 | 206709_x_at | 0.0126 | 0.9422 | |
| GSE77861 | GPT | 2875 | 206709_x_at | -0.1525 | 0.2799 | |
| GSE97050 | GPT | 2875 | A_33_P3301871 | -0.0294 | 0.9010 | |
| SRP007169 | GPT | 2875 | RNAseq | -4.3606 | 0.0000 | |
| SRP064894 | GPT | 2875 | RNAseq | -2.0775 | 0.0000 | |
| SRP133303 | GPT | 2875 | RNAseq | -1.2021 | 0.0000 | |
| SRP159526 | GPT | 2875 | RNAseq | -0.6920 | 0.1728 | |
| SRP193095 | GPT | 2875 | RNAseq | -1.6079 | 0.0000 | |
| SRP219564 | GPT | 2875 | RNAseq | -0.6072 | 0.3602 | |
| TCGA | GPT | 2875 | RNAseq | -1.8771 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by GPT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPT | 2875 | 17 | 1 | 12 | |
| GSE20123 | GPT | 2875 | 17 | 1 | 12 | |
| GSE43470 | GPT | 2875 | 16 | 2 | 25 | |
| GSE46452 | GPT | 2875 | 28 | 0 | 31 | |
| GSE47630 | GPT | 2875 | 25 | 1 | 14 | |
| GSE54993 | GPT | 2875 | 0 | 25 | 45 | |
| GSE54994 | GPT | 2875 | 39 | 1 | 13 | |
| GSE60625 | GPT | 2875 | 3 | 4 | 4 | |
| GSE74703 | GPT | 2875 | 14 | 1 | 21 | |
| GSE74704 | GPT | 2875 | 10 | 0 | 10 | |
| TCGA | GPT | 2875 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of GPT:
Generating mutation plots.
Highly correlated genes for GPT:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPT | C7orf61 | 0.809332 | 3 | 0 | 3 |
| GPT | BTBD8 | 0.808136 | 3 | 0 | 3 |
| GPT | TDGF1 | 0.796034 | 3 | 0 | 3 |
| GPT | HOTAIR | 0.773263 | 3 | 0 | 3 |
| GPT | CLDN24 | 0.768518 | 3 | 0 | 3 |
| GPT | SHANK1 | 0.761613 | 4 | 0 | 4 |
| GPT | FBXO15 | 0.756673 | 3 | 0 | 3 |
| GPT | OR2Z1 | 0.755121 | 3 | 0 | 3 |
| GPT | RTN4RL1 | 0.743502 | 3 | 0 | 3 |
| GPT | WFIKKN2 | 0.730402 | 3 | 0 | 3 |
| GPT | OR10G3 | 0.723352 | 3 | 0 | 3 |
| GPT | SOHLH1 | 0.723102 | 3 | 0 | 3 |
| GPT | SLC39A5 | 0.721516 | 3 | 0 | 3 |
| GPT | NLRP13 | 0.720877 | 3 | 0 | 3 |
| GPT | ZAN | 0.720496 | 3 | 0 | 3 |
| GPT | PRDM16 | 0.708018 | 3 | 0 | 3 |
| GPT | RAD52 | 0.701773 | 3 | 0 | 3 |
| GPT | CPA5 | 0.701557 | 3 | 0 | 3 |
| GPT | OR13G1 | 0.69773 | 3 | 0 | 3 |
| GPT | BARHL2 | 0.691224 | 3 | 0 | 3 |
For details and further investigation, click here
