| Full name: histamine receptor H3 | Alias Symbol: GPCR97 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 11255 | HGNC ID: HGNC:5184 | Ensembl Gene: ENSG00000101180 | OMIM ID: 604525 |
| Drug and gene relationship at DGIdb | |||
Expression of HRH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HRH3 | 11255 | 221663_x_at | 0.0890 | 0.6318 | |
| GSE20347 | HRH3 | 11255 | 221663_x_at | -0.0643 | 0.3005 | |
| GSE23400 | HRH3 | 11255 | 221663_x_at | -0.1572 | 0.0004 | |
| GSE26886 | HRH3 | 11255 | 221663_x_at | 0.1888 | 0.1002 | |
| GSE29001 | HRH3 | 11255 | 221663_x_at | -0.0956 | 0.5862 | |
| GSE38129 | HRH3 | 11255 | 221663_x_at | -0.0365 | 0.6125 | |
| GSE45670 | HRH3 | 11255 | 221663_x_at | 0.0462 | 0.5672 | |
| GSE53622 | HRH3 | 11255 | 52627 | -0.2748 | 0.3718 | |
| GSE53624 | HRH3 | 11255 | 52627 | -0.5270 | 0.0099 | |
| GSE63941 | HRH3 | 11255 | 221663_x_at | 0.3001 | 0.0163 | |
| GSE77861 | HRH3 | 11255 | 221663_x_at | -0.0667 | 0.6806 | |
| GSE97050 | HRH3 | 11255 | A_24_P301837 | 0.3472 | 0.4031 | |
| TCGA | HRH3 | 11255 | RNAseq | -1.3395 | 0.1334 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HRH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HRH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HRH3 | 11255 | 13 | 2 | 15 | |
| GSE20123 | HRH3 | 11255 | 14 | 2 | 14 | |
| GSE43470 | HRH3 | 11255 | 11 | 1 | 31 | |
| GSE46452 | HRH3 | 11255 | 35 | 0 | 24 | |
| GSE47630 | HRH3 | 11255 | 25 | 1 | 14 | |
| GSE54993 | HRH3 | 11255 | 0 | 17 | 53 | |
| GSE54994 | HRH3 | 11255 | 29 | 0 | 24 | |
| GSE60625 | HRH3 | 11255 | 0 | 0 | 11 | |
| GSE74703 | HRH3 | 11255 | 10 | 0 | 26 | |
| GSE74704 | HRH3 | 11255 | 11 | 0 | 9 | |
| TCGA | HRH3 | 11255 | 43 | 4 | 49 |
Total number of gains: 191; Total number of losses: 27; Total Number of normals: 270.
Somatic mutations of HRH3:
Generating mutation plots.
Highly correlated genes for HRH3:
Showing top 20/698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HRH3 | KLC4 | 0.717952 | 5 | 0 | 4 |
| HRH3 | RBP4 | 0.70983 | 3 | 0 | 3 |
| HRH3 | SRL | 0.696554 | 3 | 0 | 3 |
| HRH3 | PTK2B | 0.692011 | 3 | 0 | 3 |
| HRH3 | KLK14 | 0.679975 | 5 | 0 | 4 |
| HRH3 | RBFADN | 0.674133 | 4 | 0 | 3 |
| HRH3 | TNFRSF9 | 0.672905 | 5 | 0 | 4 |
| HRH3 | FRS3 | 0.670068 | 5 | 0 | 5 |
| HRH3 | DTX1 | 0.664111 | 3 | 0 | 3 |
| HRH3 | CRYBA4 | 0.656967 | 4 | 0 | 4 |
| HRH3 | MYPOP | 0.655928 | 4 | 0 | 4 |
| HRH3 | LRRC72 | 0.645977 | 3 | 0 | 3 |
| HRH3 | IL32 | 0.645075 | 3 | 0 | 3 |
| HRH3 | SERPINA6 | 0.643036 | 5 | 0 | 4 |
| HRH3 | ACADS | 0.642587 | 4 | 0 | 3 |
| HRH3 | CRTC1 | 0.641419 | 5 | 0 | 4 |
| HRH3 | PRAMEF10 | 0.641122 | 4 | 0 | 4 |
| HRH3 | CACNA1H | 0.639189 | 4 | 0 | 3 |
| HRH3 | CHST8 | 0.637982 | 4 | 0 | 4 |
| HRH3 | EFCAB6 | 0.63688 | 4 | 0 | 4 |
For details and further investigation, click here
