| Full name: fibroblast growth factor receptor substrate 3 | Alias Symbol: SNT-2|FRS2beta|FRS2B | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 10817 | HGNC ID: HGNC:16970 | Ensembl Gene: ENSG00000137218 | OMIM ID: 607744 |
| Drug and gene relationship at DGIdb | |||
Expression of FRS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FRS3 | 10817 | 219907_at | 0.4090 | 0.1648 | |
| GSE20347 | FRS3 | 10817 | 219907_at | 0.3844 | 0.0002 | |
| GSE23400 | FRS3 | 10817 | 219907_at | -0.0415 | 0.4895 | |
| GSE26886 | FRS3 | 10817 | 219907_at | 0.5611 | 0.0001 | |
| GSE29001 | FRS3 | 10817 | 219907_at | 0.1790 | 0.2097 | |
| GSE38129 | FRS3 | 10817 | 219907_at | 0.1779 | 0.0330 | |
| GSE45670 | FRS3 | 10817 | 219907_at | 0.0098 | 0.9387 | |
| GSE63941 | FRS3 | 10817 | 219907_at | -0.0726 | 0.8191 | |
| GSE77861 | FRS3 | 10817 | 219907_at | 0.0338 | 0.8523 | |
| SRP007169 | FRS3 | 10817 | RNAseq | 0.4032 | 0.5980 | |
| SRP064894 | FRS3 | 10817 | RNAseq | 0.8354 | 0.0000 | |
| SRP133303 | FRS3 | 10817 | RNAseq | -0.2082 | 0.3028 | |
| SRP159526 | FRS3 | 10817 | RNAseq | 0.8419 | 0.0055 | |
| SRP219564 | FRS3 | 10817 | RNAseq | 0.6501 | 0.0821 | |
| TCGA | FRS3 | 10817 | RNAseq | 0.0438 | 0.6348 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FRS3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FRS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FRS3 | 10817 | 6 | 1 | 23 | |
| GSE20123 | FRS3 | 10817 | 6 | 1 | 23 | |
| GSE43470 | FRS3 | 10817 | 6 | 0 | 37 | |
| GSE46452 | FRS3 | 10817 | 2 | 9 | 48 | |
| GSE47630 | FRS3 | 10817 | 8 | 4 | 28 | |
| GSE54993 | FRS3 | 10817 | 3 | 2 | 65 | |
| GSE54994 | FRS3 | 10817 | 11 | 4 | 38 | |
| GSE60625 | FRS3 | 10817 | 0 | 1 | 10 | |
| GSE74703 | FRS3 | 10817 | 6 | 0 | 30 | |
| GSE74704 | FRS3 | 10817 | 3 | 1 | 16 | |
| TCGA | FRS3 | 10817 | 21 | 13 | 62 |
Total number of gains: 72; Total number of losses: 36; Total Number of normals: 380.
Somatic mutations of FRS3:
Generating mutation plots.
Highly correlated genes for FRS3:
Showing top 20/726 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FRS3 | BCAT2 | 0.792521 | 3 | 0 | 3 |
| FRS3 | KLK14 | 0.772967 | 3 | 0 | 3 |
| FRS3 | PRAM1 | 0.766414 | 3 | 0 | 3 |
| FRS3 | MYPOP | 0.749383 | 3 | 0 | 3 |
| FRS3 | CHD5 | 0.714781 | 4 | 0 | 4 |
| FRS3 | RHPN1 | 0.713026 | 3 | 0 | 3 |
| FRS3 | HMX1 | 0.707114 | 3 | 0 | 3 |
| FRS3 | MFAP2 | 0.702052 | 3 | 0 | 3 |
| FRS3 | PPP2R5B | 0.70182 | 3 | 0 | 3 |
| FRS3 | HTRA3 | 0.698788 | 3 | 0 | 3 |
| FRS3 | KLK1 | 0.694124 | 3 | 0 | 3 |
| FRS3 | ZFPM1 | 0.690104 | 3 | 0 | 3 |
| FRS3 | MEX3D | 0.685925 | 3 | 0 | 3 |
| FRS3 | FAM53A | 0.684992 | 3 | 0 | 3 |
| FRS3 | TMEM214 | 0.684724 | 3 | 0 | 3 |
| FRS3 | GLDN | 0.682726 | 3 | 0 | 3 |
| FRS3 | TIMP1 | 0.682021 | 3 | 0 | 3 |
| FRS3 | AP2A1 | 0.681197 | 3 | 0 | 3 |
| FRS3 | POLD1 | 0.680196 | 3 | 0 | 3 |
| FRS3 | APOBEC3B | 0.679808 | 3 | 0 | 3 |
For details and further investigation, click here
