| Full name: kinesin light chain 4 | Alias Symbol: bA387M24.3 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 89953 | HGNC ID: HGNC:21624 | Ensembl Gene: ENSG00000137171 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
KLC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05132 | Salmonella infection |
Expression of KLC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLC4 | 89953 | 225596_at | 0.1619 | 0.7067 | |
| GSE26886 | KLC4 | 89953 | 225596_at | 0.1342 | 0.3535 | |
| GSE45670 | KLC4 | 89953 | 225596_at | 0.0806 | 0.4164 | |
| GSE53622 | KLC4 | 89953 | 155184 | -0.0917 | 0.5247 | |
| GSE53624 | KLC4 | 89953 | 155184 | -0.3788 | 0.0024 | |
| GSE63941 | KLC4 | 89953 | 225596_at | 0.4391 | 0.0446 | |
| GSE77861 | KLC4 | 89953 | 225596_at | -0.0386 | 0.7598 | |
| GSE97050 | KLC4 | 89953 | A_23_P397308 | 0.6615 | 0.2014 | |
| SRP007169 | KLC4 | 89953 | RNAseq | 0.2358 | 0.5989 | |
| SRP008496 | KLC4 | 89953 | RNAseq | 0.2321 | 0.4597 | |
| SRP064894 | KLC4 | 89953 | RNAseq | 0.3514 | 0.0961 | |
| SRP133303 | KLC4 | 89953 | RNAseq | 0.1752 | 0.3590 | |
| SRP159526 | KLC4 | 89953 | RNAseq | 0.4693 | 0.0202 | |
| SRP193095 | KLC4 | 89953 | RNAseq | -0.6243 | 0.0498 | |
| SRP219564 | KLC4 | 89953 | RNAseq | 0.3861 | 0.4863 | |
| TCGA | KLC4 | 89953 | RNAseq | -0.3434 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLC4 | 89953 | 7 | 0 | 23 | |
| GSE20123 | KLC4 | 89953 | 7 | 0 | 23 | |
| GSE43470 | KLC4 | 89953 | 6 | 0 | 37 | |
| GSE46452 | KLC4 | 89953 | 2 | 9 | 48 | |
| GSE47630 | KLC4 | 89953 | 8 | 4 | 28 | |
| GSE54993 | KLC4 | 89953 | 3 | 2 | 65 | |
| GSE54994 | KLC4 | 89953 | 11 | 4 | 38 | |
| GSE60625 | KLC4 | 89953 | 0 | 1 | 10 | |
| GSE74703 | KLC4 | 89953 | 6 | 0 | 30 | |
| GSE74704 | KLC4 | 89953 | 3 | 0 | 17 | |
| TCGA | KLC4 | 89953 | 21 | 13 | 62 |
Total number of gains: 74; Total number of losses: 33; Total Number of normals: 381.
Somatic mutations of KLC4:
Generating mutation plots.
Highly correlated genes for KLC4:
Showing top 20/76 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLC4 | HRH3 | 0.717952 | 5 | 0 | 4 |
| KLC4 | GRK6 | 0.71079 | 3 | 0 | 3 |
| KLC4 | CSN3 | 0.662534 | 3 | 0 | 3 |
| KLC4 | PRB1 | 0.65888 | 3 | 0 | 3 |
| KLC4 | DXO | 0.655567 | 3 | 0 | 3 |
| KLC4 | PRB4 | 0.654871 | 3 | 0 | 3 |
| KLC4 | FOXH1 | 0.645845 | 3 | 0 | 3 |
| KLC4 | CACNG4 | 0.640089 | 4 | 0 | 4 |
| KLC4 | WDR11-AS1 | 0.63723 | 4 | 0 | 3 |
| KLC4 | SLC17A4 | 0.630457 | 4 | 0 | 3 |
| KLC4 | TRAPPC1 | 0.628585 | 3 | 0 | 3 |
| KLC4 | LIPE | 0.62809 | 3 | 0 | 3 |
| KLC4 | C5orf34 | 0.624614 | 3 | 0 | 3 |
| KLC4 | IZUMO2 | 0.622614 | 3 | 0 | 3 |
| KLC4 | BTK | 0.620675 | 3 | 0 | 3 |
| KLC4 | SMCP | 0.620427 | 4 | 0 | 3 |
| KLC4 | GJB4 | 0.6179 | 5 | 0 | 4 |
| KLC4 | SYNGAP1 | 0.617001 | 4 | 0 | 4 |
| KLC4 | TSACC | 0.606976 | 4 | 0 | 4 |
| KLC4 | TMEM221 | 0.606216 | 3 | 0 | 3 |
For details and further investigation, click here
