| Full name: TNF receptor superfamily member 9 | Alias Symbol: CD137|4-1BB | ||
| Type: protein-coding gene | Cytoband: 1p36.23 | ||
| Entrez ID: 3604 | HGNC ID: HGNC:11924 | Ensembl Gene: ENSG00000049249 | OMIM ID: 602250 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFRSF9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF9 | 3604 | 207536_s_at | 0.9157 | 0.1880 | |
| GSE20347 | TNFRSF9 | 3604 | 207536_s_at | 0.3251 | 0.0263 | |
| GSE23400 | TNFRSF9 | 3604 | 207536_s_at | -0.0117 | 0.8659 | |
| GSE26886 | TNFRSF9 | 3604 | 238950_at | 0.1532 | 0.2919 | |
| GSE29001 | TNFRSF9 | 3604 | 207536_s_at | -0.0328 | 0.8550 | |
| GSE38129 | TNFRSF9 | 3604 | 207536_s_at | 0.3696 | 0.0155 | |
| GSE45670 | TNFRSF9 | 3604 | 207536_s_at | 0.7420 | 0.0073 | |
| GSE53622 | TNFRSF9 | 3604 | 60419 | 1.2172 | 0.0000 | |
| GSE53624 | TNFRSF9 | 3604 | 60419 | 0.8877 | 0.0000 | |
| GSE63941 | TNFRSF9 | 3604 | 207536_s_at | 1.3312 | 0.0973 | |
| GSE77861 | TNFRSF9 | 3604 | 238950_at | -0.0424 | 0.6853 | |
| GSE97050 | TNFRSF9 | 3604 | A_23_P51936 | 0.7084 | 0.1200 | |
| SRP007169 | TNFRSF9 | 3604 | RNAseq | 1.4604 | 0.0496 | |
| SRP008496 | TNFRSF9 | 3604 | RNAseq | 0.8546 | 0.0626 | |
| SRP064894 | TNFRSF9 | 3604 | RNAseq | 0.6601 | 0.0068 | |
| SRP133303 | TNFRSF9 | 3604 | RNAseq | 0.5470 | 0.0001 | |
| SRP159526 | TNFRSF9 | 3604 | RNAseq | 0.3739 | 0.4889 | |
| SRP193095 | TNFRSF9 | 3604 | RNAseq | 0.3958 | 0.0023 | |
| SRP219564 | TNFRSF9 | 3604 | RNAseq | 1.1691 | 0.0288 | |
| TCGA | TNFRSF9 | 3604 | RNAseq | 1.8506 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TNFRSF9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF9 | 3604 | 2 | 5 | 23 | |
| GSE20123 | TNFRSF9 | 3604 | 2 | 3 | 25 | |
| GSE43470 | TNFRSF9 | 3604 | 6 | 5 | 32 | |
| GSE46452 | TNFRSF9 | 3604 | 7 | 1 | 51 | |
| GSE47630 | TNFRSF9 | 3604 | 8 | 4 | 28 | |
| GSE54993 | TNFRSF9 | 3604 | 3 | 2 | 65 | |
| GSE54994 | TNFRSF9 | 3604 | 14 | 3 | 36 | |
| GSE60625 | TNFRSF9 | 3604 | 0 | 0 | 11 | |
| GSE74703 | TNFRSF9 | 3604 | 5 | 3 | 28 | |
| GSE74704 | TNFRSF9 | 3604 | 2 | 0 | 18 | |
| TCGA | TNFRSF9 | 3604 | 11 | 22 | 63 |
Total number of gains: 60; Total number of losses: 48; Total Number of normals: 380.
Somatic mutations of TNFRSF9:
Generating mutation plots.
Highly correlated genes for TNFRSF9:
Showing top 20/702 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF9 | TCTN1 | 0.791594 | 3 | 0 | 3 |
| TNFRSF9 | CAPN12 | 0.780877 | 3 | 0 | 3 |
| TNFRSF9 | SUSD3 | 0.773225 | 3 | 0 | 3 |
| TNFRSF9 | PREX1 | 0.767394 | 3 | 0 | 3 |
| TNFRSF9 | TCF25 | 0.738095 | 4 | 0 | 3 |
| TNFRSF9 | GDF11 | 0.735626 | 3 | 0 | 3 |
| TNFRSF9 | CD53 | 0.734492 | 4 | 0 | 4 |
| TNFRSF9 | PIK3AP1 | 0.723404 | 3 | 0 | 3 |
| TNFRSF9 | MICALCL | 0.722173 | 3 | 0 | 3 |
| TNFRSF9 | EML4 | 0.722002 | 3 | 0 | 3 |
| TNFRSF9 | HOXD8 | 0.719934 | 4 | 0 | 3 |
| TNFRSF9 | CUL7 | 0.717439 | 4 | 0 | 4 |
| TNFRSF9 | GAS2L1 | 0.717256 | 3 | 0 | 3 |
| TNFRSF9 | RALGAPA2 | 0.714972 | 3 | 0 | 3 |
| TNFRSF9 | GATA6 | 0.714147 | 3 | 0 | 3 |
| TNFRSF9 | GRINA | 0.711826 | 4 | 0 | 4 |
| TNFRSF9 | MED12 | 0.711249 | 4 | 0 | 4 |
| TNFRSF9 | SAMD4B | 0.710514 | 3 | 0 | 3 |
| TNFRSF9 | RAB7B | 0.703187 | 3 | 0 | 3 |
| TNFRSF9 | GOSR2 | 0.693387 | 3 | 0 | 3 |
For details and further investigation, click here
