| Full name: sarcalumenin | Alias Symbol: SAR | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 6345 | HGNC ID: HGNC:11295 | Ensembl Gene: ENSG00000185739 | OMIM ID: 604992 |
| Drug and gene relationship at DGIdb | |||
Expression of SRL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRL | 6345 | 235718_at | -0.0018 | 0.9960 | |
| GSE26886 | SRL | 6345 | 235718_at | 0.2056 | 0.0326 | |
| GSE45670 | SRL | 6345 | 235718_at | -0.1649 | 0.1154 | |
| GSE53622 | SRL | 6345 | 149737 | -0.9954 | 0.0000 | |
| GSE53624 | SRL | 6345 | 126154 | -2.0176 | 0.0000 | |
| GSE63941 | SRL | 6345 | 235718_at | 0.0875 | 0.5769 | |
| GSE77861 | SRL | 6345 | 235718_at | -0.0523 | 0.7415 | |
| SRP064894 | SRL | 6345 | RNAseq | -0.8966 | 0.0365 | |
| SRP133303 | SRL | 6345 | RNAseq | -1.2866 | 0.0000 | |
| SRP159526 | SRL | 6345 | RNAseq | -2.2516 | 0.0000 | |
| SRP219564 | SRL | 6345 | RNAseq | -0.5909 | 0.1738 | |
| TCGA | SRL | 6345 | RNAseq | -1.4785 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SRL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRL | 6345 | 5 | 5 | 20 | |
| GSE20123 | SRL | 6345 | 5 | 4 | 21 | |
| GSE43470 | SRL | 6345 | 5 | 6 | 32 | |
| GSE46452 | SRL | 6345 | 38 | 1 | 20 | |
| GSE47630 | SRL | 6345 | 13 | 6 | 21 | |
| GSE54993 | SRL | 6345 | 3 | 5 | 62 | |
| GSE54994 | SRL | 6345 | 5 | 9 | 39 | |
| GSE60625 | SRL | 6345 | 4 | 0 | 7 | |
| GSE74703 | SRL | 6345 | 5 | 4 | 27 | |
| GSE74704 | SRL | 6345 | 3 | 2 | 15 | |
| TCGA | SRL | 6345 | 19 | 13 | 64 |
Total number of gains: 105; Total number of losses: 55; Total Number of normals: 328.
Somatic mutations of SRL:
Generating mutation plots.
Highly correlated genes for SRL:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRL | C9orf16 | 0.723702 | 3 | 0 | 3 |
| SRL | DLGAP3 | 0.700635 | 3 | 0 | 3 |
| SRL | DOC2A | 0.698961 | 3 | 0 | 3 |
| SRL | HRH3 | 0.696554 | 3 | 0 | 3 |
| SRL | NFAM1 | 0.694632 | 3 | 0 | 3 |
| SRL | SH3BP1 | 0.690799 | 3 | 0 | 3 |
| SRL | GGT5 | 0.685244 | 3 | 0 | 3 |
| SRL | CYP2A13 | 0.682043 | 3 | 0 | 3 |
| SRL | C20orf141 | 0.681907 | 4 | 0 | 3 |
| SRL | RENBP | 0.673739 | 3 | 0 | 3 |
| SRL | CT55 | 0.668247 | 3 | 0 | 3 |
| SRL | GRM2 | 0.65115 | 3 | 0 | 3 |
| SRL | COL26A1 | 0.645107 | 3 | 0 | 3 |
| SRL | CABIN1 | 0.642009 | 3 | 0 | 3 |
| SRL | VWA1 | 0.633033 | 3 | 0 | 3 |
| SRL | CRTC1 | 0.632473 | 3 | 0 | 3 |
| SRL | ADM2 | 0.631741 | 3 | 0 | 3 |
| SRL | F10 | 0.626677 | 4 | 0 | 4 |
| SRL | SIRT2 | 0.621293 | 3 | 0 | 3 |
| SRL | PYGM | 0.620617 | 3 | 0 | 3 |
For details and further investigation, click here
