| Full name: heat shock protein family A (Hsp70) member 1 like | Alias Symbol: HSP70-HOM|hum70t | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 3305 | HGNC ID: HGNC:5234 | Ensembl Gene: ENSG00000204390 | OMIM ID: 140559 |
| Drug and gene relationship at DGIdb | |||
HSPA1L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04213 | Longevity regulating pathway - multiple species | |
| hsa05134 | Legionellosis | |
| hsa05145 | Toxoplasmosis | |
| hsa05164 | Influenza A |
Expression of HSPA1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPA1L | 3305 | 233694_at | -0.0078 | 0.9866 | |
| GSE20347 | HSPA1L | 3305 | 210189_at | -0.0449 | 0.7018 | |
| GSE23400 | HSPA1L | 3305 | 210189_at | -0.0321 | 0.4794 | |
| GSE26886 | HSPA1L | 3305 | 233694_at | 0.0046 | 0.9777 | |
| GSE29001 | HSPA1L | 3305 | 210189_at | -0.1210 | 0.5543 | |
| GSE38129 | HSPA1L | 3305 | 210189_at | -0.1583 | 0.1753 | |
| GSE45670 | HSPA1L | 3305 | 233694_at | 0.0536 | 0.8566 | |
| GSE53622 | HSPA1L | 3305 | 88026 | 0.0073 | 0.9398 | |
| GSE53624 | HSPA1L | 3305 | 88026 | 0.1160 | 0.1039 | |
| GSE63941 | HSPA1L | 3305 | 233694_at | 0.2814 | 0.0751 | |
| GSE77861 | HSPA1L | 3305 | 233694_at | -0.0012 | 0.9918 | |
| GSE97050 | HSPA1L | 3305 | A_23_P70547 | -0.0854 | 0.8195 | |
| SRP064894 | HSPA1L | 3305 | RNAseq | 0.3164 | 0.2670 | |
| SRP133303 | HSPA1L | 3305 | RNAseq | -0.2532 | 0.3647 | |
| SRP159526 | HSPA1L | 3305 | RNAseq | 0.2184 | 0.6094 | |
| SRP219564 | HSPA1L | 3305 | RNAseq | -0.4761 | 0.4788 | |
| TCGA | HSPA1L | 3305 | RNAseq | -0.2400 | 0.0727 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSPA1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPA1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPA1L | 3305 | 5 | 1 | 24 | |
| GSE20123 | HSPA1L | 3305 | 5 | 1 | 24 | |
| GSE43470 | HSPA1L | 3305 | 5 | 1 | 37 | |
| GSE46452 | HSPA1L | 3305 | 1 | 10 | 48 | |
| GSE47630 | HSPA1L | 3305 | 7 | 4 | 29 | |
| GSE54993 | HSPA1L | 3305 | 2 | 1 | 67 | |
| GSE54994 | HSPA1L | 3305 | 11 | 4 | 38 | |
| GSE60625 | HSPA1L | 3305 | 0 | 1 | 10 | |
| GSE74703 | HSPA1L | 3305 | 5 | 0 | 31 | |
| GSE74704 | HSPA1L | 3305 | 2 | 0 | 18 | |
| TCGA | HSPA1L | 3305 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of HSPA1L:
Generating mutation plots.
Highly correlated genes for HSPA1L:
Showing top 20/157 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPA1L | FAM131B | 0.718738 | 3 | 0 | 3 |
| HSPA1L | HES4 | 0.704366 | 3 | 0 | 3 |
| HSPA1L | SLC2A4RG | 0.681366 | 3 | 0 | 3 |
| HSPA1L | ZFP92 | 0.661059 | 3 | 0 | 3 |
| HSPA1L | PIP5K1C | 0.660845 | 3 | 0 | 3 |
| HSPA1L | CCDC59 | 0.651949 | 3 | 0 | 3 |
| HSPA1L | EMD | 0.651438 | 4 | 0 | 3 |
| HSPA1L | PDK2 | 0.644525 | 4 | 0 | 3 |
| HSPA1L | NANOS3 | 0.640124 | 3 | 0 | 3 |
| HSPA1L | DEDD2 | 0.639026 | 4 | 0 | 3 |
| HSPA1L | PI16 | 0.638159 | 4 | 0 | 4 |
| HSPA1L | MPV17L | 0.629276 | 4 | 0 | 4 |
| HSPA1L | GH2 | 0.625768 | 5 | 0 | 3 |
| HSPA1L | TECPR2 | 0.62383 | 3 | 0 | 3 |
| HSPA1L | DTX1 | 0.621695 | 3 | 0 | 3 |
| HSPA1L | DCHS2 | 0.620164 | 4 | 0 | 3 |
| HSPA1L | POU6F1 | 0.614864 | 3 | 0 | 3 |
| HSPA1L | CELA1 | 0.612699 | 3 | 0 | 3 |
| HSPA1L | PRDX3 | 0.609774 | 3 | 0 | 3 |
| HSPA1L | GPM6B | 0.608254 | 3 | 0 | 3 |
For details and further investigation, click here
