| Full name: death effector domain containing 2 | Alias Symbol: FLAME-3 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 162989 | HGNC ID: HGNC:24450 | Ensembl Gene: ENSG00000160570 | OMIM ID: 617078 |
| Drug and gene relationship at DGIdb | |||
Expression of DEDD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEDD2 | 162989 | 225434_at | 0.0764 | 0.8652 | |
| GSE26886 | DEDD2 | 162989 | 225434_at | 0.1330 | 0.5913 | |
| GSE45670 | DEDD2 | 162989 | 225434_at | 0.4654 | 0.0545 | |
| GSE53622 | DEDD2 | 162989 | 17128 | 0.4222 | 0.0000 | |
| GSE53624 | DEDD2 | 162989 | 1625 | 0.2158 | 0.0014 | |
| GSE63941 | DEDD2 | 162989 | 225434_at | 0.7672 | 0.0406 | |
| GSE77861 | DEDD2 | 162989 | 225434_at | 0.4251 | 0.0591 | |
| GSE97050 | DEDD2 | 162989 | A_24_P207479 | 0.2287 | 0.2764 | |
| SRP007169 | DEDD2 | 162989 | RNAseq | -0.9489 | 0.0528 | |
| SRP008496 | DEDD2 | 162989 | RNAseq | -0.8703 | 0.0012 | |
| SRP064894 | DEDD2 | 162989 | RNAseq | 0.1914 | 0.4345 | |
| SRP133303 | DEDD2 | 162989 | RNAseq | 0.3062 | 0.2645 | |
| SRP159526 | DEDD2 | 162989 | RNAseq | 0.3271 | 0.0454 | |
| SRP193095 | DEDD2 | 162989 | RNAseq | 0.1459 | 0.2767 | |
| SRP219564 | DEDD2 | 162989 | RNAseq | 0.1532 | 0.6655 | |
| TCGA | DEDD2 | 162989 | RNAseq | 0.1174 | 0.0596 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEDD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEDD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEDD2 | 162989 | 4 | 4 | 22 | |
| GSE20123 | DEDD2 | 162989 | 4 | 3 | 23 | |
| GSE43470 | DEDD2 | 162989 | 4 | 11 | 28 | |
| GSE46452 | DEDD2 | 162989 | 47 | 1 | 11 | |
| GSE47630 | DEDD2 | 162989 | 8 | 6 | 26 | |
| GSE54993 | DEDD2 | 162989 | 17 | 4 | 49 | |
| GSE54994 | DEDD2 | 162989 | 7 | 12 | 34 | |
| GSE60625 | DEDD2 | 162989 | 9 | 0 | 2 | |
| GSE74703 | DEDD2 | 162989 | 4 | 7 | 25 | |
| GSE74704 | DEDD2 | 162989 | 4 | 1 | 15 | |
| TCGA | DEDD2 | 162989 | 14 | 15 | 67 |
Total number of gains: 122; Total number of losses: 64; Total Number of normals: 302.
Somatic mutations of DEDD2:
Generating mutation plots.
Highly correlated genes for DEDD2:
Showing top 20/218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEDD2 | C1orf216 | 0.75256 | 3 | 0 | 3 |
| DEDD2 | UBB | 0.741933 | 3 | 0 | 3 |
| DEDD2 | BRAP | 0.73219 | 3 | 0 | 3 |
| DEDD2 | DNAJC11 | 0.731369 | 3 | 0 | 3 |
| DEDD2 | LNP1 | 0.728075 | 3 | 0 | 3 |
| DEDD2 | OCEL1 | 0.725722 | 3 | 0 | 3 |
| DEDD2 | SLC38A7 | 0.72522 | 3 | 0 | 3 |
| DEDD2 | NAA60 | 0.721601 | 3 | 0 | 3 |
| DEDD2 | RNF130 | 0.716265 | 3 | 0 | 3 |
| DEDD2 | ACLY | 0.715595 | 3 | 0 | 3 |
| DEDD2 | EIF3G | 0.714045 | 4 | 0 | 4 |
| DEDD2 | NAF1 | 0.71339 | 3 | 0 | 3 |
| DEDD2 | ITM2C | 0.712077 | 3 | 0 | 3 |
| DEDD2 | YTHDF1 | 0.711431 | 4 | 0 | 4 |
| DEDD2 | SPOCK1 | 0.709289 | 3 | 0 | 3 |
| DEDD2 | ZFAND3 | 0.707271 | 3 | 0 | 3 |
| DEDD2 | ANKRD40 | 0.707079 | 3 | 0 | 3 |
| DEDD2 | CDC42EP4 | 0.703145 | 3 | 0 | 3 |
| DEDD2 | PACSIN2 | 0.70066 | 3 | 0 | 3 |
| DEDD2 | BNIP1 | 0.700087 | 3 | 0 | 3 |
For details and further investigation, click here
